受容体
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/04/07 09:11 UTC 版)
生化学および薬理学において、受容体（じゅようたい、英: receptor、レセプター、リセプター）は、生命システムに組み込まれる可能性のあるシグナル（信号）を受信し伝達する、タンパク質からなる化学構造体である[1]。これらのシグナルは通常は化学伝達物質であり[nb 1]、受容体に結合して、何らかの形の細胞/組織応答（例: 細胞の電気的活性の変化など）を引き起こす。受容体の働きは、シグナルの中継、増幅、統合の3つに大きく分類される[2]。シグナルを先方に中継し増幅することで、一つのリガンドの効果を増大させ統合することにより、シグナルを別の生化学的経路に組み込み、その経路もまた高度に専門化することを可能とする[2]。
- ^ a b c Hall, JE (2016). Guyton and Hall Textbook of Medical Physiology. Philadelphia, PA: Elsevier Saunders. pp. 930–937. ISBN 978-1-4557-7005-2
- ^ a b Alberts, Bruce; Bray, Dennis; Hopkin, Karen; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2014). Essential Cell Biology (Fourth ed.). New York, NY, USA: Garland Science. p. 534. ISBN 978-0-8153-4454-4
- ^ Gotti, Cecilia; Marks, Michael. J.; Millar, Neil S.; Wonnacott, Susan (16 September 2019). “Nicotinic acetylcholine receptors (version 2019.4)”. IUPHAR/BPS Guide to Pharmacology CITE 2019 (4). doi:10.2218/gtopdb/F76/2019.4 2020年11月17日閲覧。.
- ^ Malenka RC, Nestler EJ, Hyman SE (2009). “Chapter 9: Autonomic Nervous System”. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 234. ISBN 9780071481274. "Nicotine ... is a natural alkaloid of the tobacco plant. Lobeline is a natural alkaloid of Indian tobacco. Both drugs are agonists of nicotinic cholinergic receptors ..."
- ^ “Curare Drug Information, Professional” (英語). Drugs.com. 2020年12月8日閲覧。
- ^ Congreve M, Marshall F (March 2010). “The impact of GPCR structures on pharmacology and structure-based drug design”. British Journal of Pharmacology 159 (5): 986–96. doi:10.1111/j.1476-5381.2009.00476.x. PMC 2839258. PMID 19912230.
- ^ Qin K, Dong C, Wu G, Lambert NA (August 2011). “Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers”. Nature Chemical Biology 7 (10): 740–7. doi:10.1038/nchembio.642. PMC 3177959. PMID 21873996.
- ^ Zubay, Geoffrey (1998). Biochemistry 4th Ed.. Dubuque, IA: William C Brown Pub. pp. 684. ISBN 0697219003
- ^ Garrett, Reginald; Grisham, Charles (2012). Biochemistry. Cengage Learning. pp. 1130. ISBN 9781473733602
- ^ Hamm, Heidi E.; Oldham, William M. (2008). “Heterotrimeric G Protein Activation by G-Protein-Coupled Receptors”. Nature Reviews Molecular Cell Biology (Nature Publishing Group) 9 (1): 60–71. doi:10.1038/nrm2299. PMID 18043707.
- ^ a b Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G (2012). Rang & Dale's Pharmacology (7th ed.). Elsevier Churchill Livingstone. ISBN 978-0-7020-3471-8
- ^ Milligan G (December 2003). “Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective”. Molecular Pharmacology 64 (6): 1271–6. doi:10.1124/mol.64.6.1271. PMID 14645655.
- ^ Rang, HP (January 2006). “The receptor concept: pharmacology's big idea”. British Journal of Pharmacology 147 Suppl 1: S9-16. doi:10.1038/sj.bjp.0706457. PMC 1760743. PMID 16402126.
- ^ Ariens EJ (September 1954). “Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory”. Archives Internationales de Pharmacodynamie et de Therapie 99 (1): 32–49. PMID 13229418.
- ^ Stephenson RP (December 1956). “A modification of receptor theory”. British Journal of Pharmacology and Chemotherapy 11 (4): 379–93. doi:10.1111/j.1476-5381.1956.tb00006.x. PMC 1510558. PMID 13383117.
- ^ Silverman RB (2004). “3.2.C Theories for Drug—Receptor Interactions”. The Organic Chemistry of Drug Design and Drug Action (2nd ed.). Amsterdam: Elsevier Academic Press. ISBN 0-12-643732-7
- ^ Boulay G, Chrétien L, Richard DE, Guillemette G (November 1994). “Short-term desensitization of the angiotensin II receptor of bovinde adrenal glomerulosa cells corresponds to a shift from a high to low affinity state”. Endocrinology 135 (5): 2130–6. doi:10.1210/en.135.5.2130. PMID 7956936.
- ^ a b c d e f g h i j k l Boulpaep EL, Boron WF (2005). Medical Physiology: A Cellular and Molecular Approach. St. Louis, Mo: Elsevier Saunders. p. 90. ISBN 1-4160-2328-3
- ^ Waltenbaugh C, Doan T, Melvold R, Viselli S (2008). Immunology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 20. ISBN 978-0-7817-9543-2
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