血管内皮細胞増殖因子
血管内皮細胞増殖因子
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/03 15:23 UTC 版)
血管内皮細胞増殖因子（けっかんないひさいぼうぞうしょくいんし）は、脈管形成（胚形成期に、血管がないところに新たに血管がつくられること）および血管新生（既存の血管から分枝伸長して血管を形成すること）に関与する一群の糖タンパク。英語の vascular endothelial growth factor から VEGF（ブイイージーエフ）と呼ばれることが多い。その他、血管内皮細胞成長因子、血管内皮増殖因子、血管内皮成長因子などと呼ばれることもある。VEGFは主に血管内皮細胞表面にある血管内皮細胞増殖因子受容体 (VEGFR) にリガンドとして結合し、細胞分裂や遊走、分化を刺激したり、微小血管の血管透過性を亢進させたりする働きをもつが、その他単球・マクロファージの活性化にも関与する。正常な体の血管新生に関わる他、腫瘍の血管形成や転移など、悪性化の過程にも関与している。
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- ^ Entrez Gene: VEGFA
- ^ Entrez Gene: VEGFB
- ^ Entrez Gene: VEGFC
- ^ Entrez Gene: FIGF
- ^ Entrez Gene: PGF
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- ^ Yuan A, Yu CJ, Kuo SH, et al. "Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer." Journal of Clinical Oncology, 19, 2001, p.p. 432-441. PMID 11208836
- ^ 日本病院薬剤師会雑誌(2008) 44,863-70.
[続きの解説]
「血管内皮細胞増殖因子」の続きの解説一覧
- 1 血管内皮細胞増殖因子とは
- 2 血管内皮細胞増殖因子の概要
- 3 VEGFを標的にした薬剤
- 血管内皮細胞増殖因子のページへのリンク
