糖化最終産物とは？ わかりやすく解説

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デジタル大辞泉
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とうか‐さいしゅうさんぶつ〔タウクワ‐〕【糖化最終産物】

読み方：とうかさいしゅうさんぶつ

⇒エイジス（AGEs）


ウィキペディア
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AGEs

(糖化最終産物 から転送)

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/08/30 23:42 UTC 版)

AGEs（エージス、エイジス、エイジズ、エージーイー）とは、Advanced Glycation End Productsの略語であり、終末糖化産物、後期糖化生成物などと訳される。タンパク質または脂質が糖へ曝露されることによる糖化反応（メイラード反応）によって作られた生成物の総称であり[1]、身体の様々な老化に関与する物質（より正確に言えば、生体化学反応による生成物）と言える。現在判明しているだけでも、AGEsには数十種類の化合物があり、それぞれが多種多様な化学的性質を有する。AGEsの例としては、Nε-カルボキシメチルリシン(CML)、Nε-カルボキシエチルリシン(CEL)、アルグピリミジンなどが知られている。類似の概念に過酸化脂質に由来する終末過酸化産物（Advanced Lipoxidation End products、ALEs）がある[2]。（ALEsについては脂質過酸化反応も参照の事）


出典
  1. ^ Goldin A, Beckman JA, Schmidt AM, Creager MA (2006-08-08). “Advanced glycation end products: sparking the development of diabetic vascular injury.”. Circulation 114 (6): 597-605. doi:10.1161/CIRCULATIONAHA.106.621854. PMID 16894049. http://circ.ahajournals.org/content/114/6/597.short. 
  2. ^ a b Vistoli, G; De Maddis, D; Cipak, A; Zarkovic, N; Carini, M; Aldini, G (Aug 2013). “Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation.”. Free Radic Res. 47 (12): Suppl 1:3–27. doi:10.3109/10715762.2013.815348. PMID 10946212. 
  3. ^ a b JAIME URIBARRI, SANDRA WOODRUFF, SUSAN GOODMAN, WEIJING CAI, XUE CHEN, RENATA PYZIK, ANGIE YONG, GARY E. STRIKER, HELEN VLASSARA (2010年6月). “Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet”. 2015年2月22日閲覧。
  4. ^ Nagai R, Ikeda K, Higashi T, et al (1997-05-08). “Hydroxyl radical mediates Nε-(carboxymethyl)lysine formation from Amadori product.”. Biochem Biophys Res Commun 234 (1): 167-72. doi:10.1006/bbrc.1997.6608. PMID 9168983. http://www.sciencedirect.com/science/article/pii/S0006291X97966080. 
  5. ^ Nagai R, Fujiwara Y, Mera K, et al (2008-03-20). “Immunochemical detection of Nε-(carboxyethyl)lysine using a specific antibody.”. J Immunol Methods. 332 (1-2): 112-20. doi:10.1016/j.jim.2007.12.020. PMID 18242632. http://www.sciencedirect.com/science/article/pii/S0022175908000033. 
  6. ^ Sell DR, Monnier VM (1989-12-25). “Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.”. J Biol Chem. 264 (36): 21597-602. PMID 2513322. http://www.jbc.org/content/264/36/21597.full.pdf. 
  7. ^ Hayase F, Nagaraj RH, Miyata S, et al. (1989-03-05). “Aging of proteins: immunological detection of a glucose-derived pyrrole formed during Maillard reaction in vivo.”. J Biol Chem. 263 (7): 3758–64. PMID 2917974. http://www.jbc.org/content/264/7/3758.full.pdf. 
  8. ^ Ienaga K, Nakamura K, Hochi T, et al (1995). “Crosslines, fluorophores in the AGE-related cross-linked proteins.”. Contrib Nephrol. 112: 42-51. PMID 7554992. 
  9. ^ Nagai R, Hayashi CM, Xia L, et al. (2002-12-13). “Identification in Human Atherosclerotic Lesions of GA-pyridine, a Novel Structure Derived from Glycolaldehyde-modified Proteins.”. J Biol Chem. 277 (50): 48905-12. PMID 12377783. http://www.jbc.org/content/277/50/48905.full. 
  10. ^ Iijima K, Murata M, Takahara H, et al (2000-04-01). “Identification of Nω-carboxymethylarginine as a novel acid-labile advanced glycation end product in collagen.”. Biochem J. 347 (Pt.1): 23-7. doi:10.1042/bj3470023. PMID 10727397. http://www.biochemj.org/content/347/1/23. 
  11. ^ Ulrich P, Cerami A. (2001). “Protein glycation, diabetes, and aging.”. Recent Prog Horm Res. 56: 1-21. PMID 11237208. 
  12. ^ Miyata, T; Oda, O; Inagi, R; Iida, Y; Araki, N; Yamada, N; Horiuchi, S; Taniguchi, N et al. (September 1993). “beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis.”. The Journal of Clinical Investigation 92 (3): 1243–52. doi:10.1172/JCI116696. PMC 288264. PMID 8376584. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC288264/. 
  13. ^ a b c Uribarri, J; Woodruff, S; Goodman, S; Cai, W; Chen, X; Pyzik, R; Yong, A; Striker, GE et al. (June 2010). “Advanced glycation end products in foods and a practical guide to their reduction in the diet”. Journal of the American Dietetic Association 110 (6): 911–16.e12. doi:10.1016/j.jada.2010.03.018. PMC 3704564. PMID 20497781. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704564/. 
  14. ^ a b Koschinsky, T; He, CJ; Mitsuhashi, T; Bucala, R; Liu, C; Buenting, C; Heitmann, K; Vlassara, H (Jun 10, 1997). “Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy.”. Proceedings of the National Academy of Sciences of the United States of America 94 (12): 6474–9. doi:10.1073/pnas.94.12.6474. PMC 21074. PMID 9177242. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21074/. 
  15. ^ Goldin A, Beckman JA, Schmidt AM, Creager MA (2006). “Advanced glycation end products: sparking the development of diabetic vascular injury”. Circulation 114 (6): 597–605. doi:10.1161/CIRCULATIONAHA.106.621854. PMID 16894049. 
  16. ^ Song X, Bao M, Li D, Li YM (1999). “Advanced glycation in D-galactose induced mouse aging model”. Mech Ageing Dev 108 (3): 239–51. doi:10.1016/S0047-6374(99)00022-6. PMID 10405984. 
  17. ^ Gugliucci A, Kotani K, Taing J, et al. (2009-08). “Short-Term Low Calorie Diet Intervention Reduces Serum Advanced Glycation End Products in Healthy Overweight or Obese Adults.”. Ann Nutr Metab. 54 (3): 197-201. doi:10.1159/000217817. PMID 19420913. https://www.karger.com/Article/Abstract/217817. 
  18. ^ a b Brownlee, M (June 2005). “The pathobiology of diabetic complications: a unifying mechanism.”. Diabetes 54 (6): 1615–25. doi:10.2337/diabetes.54.6.1615. PMID 15919781. 
  19. ^ Dominiczak MH (2003). “Obesity, glucose intolerance and diabetes and their links to cardiovascular disease. Implications for laboratory medicine”. Clin. Chem. Lab. Med. 41 (9): 1266–78. doi:10.1515/CCLM.2003.194. PMID 14598880. 
  20. ^ Gugliucci, A (October 2000). “Glycation as the glucose link to diabetic complications.”. The Journal of the American Osteopathic Association 100 (10): 621–34. PMID 11105451. 
  21. ^ Topol, Eric J.; Robert M. Califf (2006). Textbook of Cardiovascular Medicine. Lippincott Williams & Wilkins. p. 42. ISBN 0-7817-7012-2 
  22. ^ Vlassara H, Palace MR.; Palace (2002). “Diabetes and advanced glycation endproducts”. J Intern Med. 251 (2): 87–101. doi:10.1046/j.1365-2796.2002.00932.x. PMID 11905595. 
  23. ^ Glenn, J.; Stitt, A. (2009). “The role of advanced glycation end products in retinal ageing and disease”. Biochimica et Biophysica Acta 1790 (10): 1109–1116. doi:10.1016/j.bbagen.2009.04.016. PMID 19409449. 
  24. ^ Semba, R. D.; Ferrucci, L.; Sun, K.; Beck, J.; Dalal, M.; Varadhan, R.; Walston, J.; Guralnik, J. M. et al. (2009). “Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women”. Aging clinical and experimental research 21 (2): 182–190. doi:10.1007/BF03325227. PMC 2684987. PMID 19448391. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684987/. 
  25. ^ Semba, R.; Najjar, S.; Sun, K.; Lakatta, E.; Ferrucci, L. (2009). “Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults”. American journal of hypertension 22 (1): 74–79. doi:10.1038/ajh.2008.320. PMC 2637811. PMID 19023277. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637811/. 
  26. ^ Yan, S. F.; D'Agati, V.; Schmidt, A. M.; Ramasamy, R. (2007). “Receptor for Advanced Glycation Endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging”. Current molecular medicine 7 (8): 699–710. doi:10.2174/156652407783220732. PMID 18331228. 
  27. ^ Pertyńska-Marczewska, M; Głowacka, E; Sobczak, M; Cypryk, K; Wilczyński, J (February 2009). “Glycation endproducts, soluble receptor for advanced glycation endproducts and cytokines in diabetic and non-diabetic pregnancies.”. American journal of reproductive immunology (New York, N.Y. : 1989) 61 (2): 175–82. doi:10.1111/j.1600-0897.2008.00679.x. PMID 19143681. 
  28. ^ Tan, KC; Chow, WS; Lam, JC; Lam, B; Bucala, R; Betteridge, J; Ip, MS (March 2006). “Advanced glycation endproducts in nondiabetic patients with obstructive sleep apnea.”. Sleep 29 (3): 329–33. PMID 16553018. 
  29. ^ Srikanth, V; Maczurek, A; Phan, T; Steele, M; Westcott, B; Juskiw, D; Münch, G (May 2011). “Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.”. Neurobiology of Aging 32 (5): 763–77. doi:10.1016/j.neurobiolaging.2009.04.016. PMID 19464758. 
  30. ^ Simm, A; Wagner, J; Gursinsky, T; Nass, N; Friedrich, I; Schinzel, R; Czeslik, E; Silber, RE et al. (July 2007). “Advanced glycation endproducts: a biomarker for age as an outcome predictor after cardiac surgery?”. Experimental Gerontology 42 (7): 668–75. doi:10.1016/j.exger.2007.03.006. PMID 17482402. 
  31. ^ Zimmerman GA, Meistrell M 3rd, Bloom O, et al. (1995-04-25). “Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine.”. Proc Natl Acad Sci USA. 92 (9): 3744-8. PMID 7731977. 
  32. ^ Shaikh S, Nicholson LF (2008-07). “Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation.”. J Neurosci Res. 86 (9): 2071-82. doi:10.1002/jnr.21644. PMID 18335520. 
  33. ^ Fuentealba D, Friguet B, Silva E (2009). “Advanced glycation endproducts induce photocrosslinking and oxidation of bovine lens proteins through type-I mechanism.”. Photochem Photobiol. 85 (1): 185-94. doi:10.1111/j.1751-1097.2008.00415.x. PMID 18673320. 
  34. ^ Gul A, Rahman MA, Hasnain SN (2009-06). “Role of fructose concentration on cataractogenesis in senile diabetic and non-diabetic patients.”. Graefes Arch Clin Exp Ophthalmol. 247 (6): 809-14. doi:10.1007/s00417-008-1027-9. PMID 19198870. 
  35. ^ Haus, JM; Carrithers, JA; Trappe, SW; Trappe, TA (December 2007). “Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle.”. Journal of applied physiology (Bethesda, Md. : 1985) 103 (6): 2068–76. doi:10.1152/japplphysiol.00670.2007. PMID 17901242. 
  36. ^ a b c d e f g Gugliucci A, Bendayan M (1996). “Renal fate of circulating advanced glycated end products (AGE): evidence for reabsorption and catabolism of AGE peptides by renal proximal tubular cells”. Diabetologia 39 (2): 149–60. doi:10.1007/BF00403957. PMID 8635666. http://www.nature.com/ki/journal/v53/n2/full/4490049a.html. 
  37. ^ a b c Yan HD, Li XZ, Xie JM, Li M (2007). “Effects of advanced glycation end products on renal fibrosis and oxidative stress in cultured NRK-49F cells”. Chin. Med. J. 120 (9): 787–93. PMID 17531120. https://web.archive.org/web/20090810100221/http://www.cmj.org/Periodical/paperlist.asp?id=LW2007429414606901754&linkintype=pubmed. 
  38. ^ a b Ansari NA1, Moinuddin, Ali R (2011). “Glycated lysine residues: a marker for non-enzymatic protein glycation in age-related diseases”. DISEASE MARKERS 30 (6): 317-324. doi:10.3233/DMA-2011-0791. PMC 3825483. PMID 21725160. http://www.hindawi.com/journals/dm/2011/718694/abs/. 
  39. ^ Brett J, Schmidt AM, Yan SD, et al. (1993-12). “Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.”. Am J Pathol. 143 (6): 1699-712. PMID 8256857. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887265/. 
  40. ^ “糖化ストレスとAGEs受容体”. からだサポート研究所. 2015年9月21日閲覧。
  41. ^ a b Wells-Knecht KJ, Zyzak DV, Litchfield JE, Thorpe SR, Baynes JW (1995). “Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose”. Biochemistry 34 (11): 3702–9. doi:10.1021/bi00011a027. PMID 7893666. 
  42. ^ a b c Gugliucci A, Mehlhaff K, Kinugasa E (2007). “Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance”. Clin. Chim. Acta 377 (1–2): 213–20. doi:10.1016/j.cca.2006.09.028. PMID 17118352. 
  43. ^ Smedsrød B, Melkko J, Araki N, Sano H, Horiuchi S (1997). “Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells”. Biochem. J. 322 (Pt 2): 567–73. PMC 1218227. PMID 9065778. http://www.biochemj.org/bj/322/0567/bj3220567.htm. 
  44. ^ Svistounov D, Smedsrød B (2004). “Hepatic clearance of advanced glycation end products (AGEs)—myth or truth?”. J. Hepatol. 41 (6): 1038–40. doi:10.1016/j.jhep.2004.10.004. PMID 15582139. 
  45. ^ Hira Zafar, (26 June 2012). “Inhibition of protein glycation and advanced glycation end products by ascorbic acid”. African Journal of Biotechnology 11 (51). doi:10.5897/AJB11.4172. 
  46. ^ Abdul, HM; Butterfield, DA (Feb 1, 2007). “Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.”. Free radical biology & medicine 42 (3): 371–84. doi:10.1016/j.freeradbiomed.2006.11.006. PMC 1808543. PMID 17210450. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808543/. 
  47. ^ Nandhini AT, Thirunavukkarasu V, Anuradha CV (August 2005). “Taurine prevents collagen abnormalities in high fructose-fed rats”. Indian J. Med. Res. 122 (2): 171–7. PMID 16177476. http://www.icmr.nic.in/ijmr/2005/august/0911.pdf. 
  48. ^ A. Gugliucci. “Sour Side of Sugar, A Glycation Web Page”. 2015年9月21日閲覧。
  49. ^ “Aspirin inhibits the formation of... preview & related info”. Mendeley. doi:10.1016/j.diabres.2006.12.024. 2013年11月13日閲覧。
  50. ^ Bucala R, Cerami A (1992). “Advanced glycosylation: chemistry, biology, and implications for diabetes and aging”. Adv. Pharmacol.. Advances in Pharmacology 23: 1–34. doi:10.1016/S1054-3589(08)60961-8. ISBN 9780120329236. PMID 1540533. 
  51. ^ Guiotto A, Calderan A, Ruzza P, Borin G (2005). “Carnosine and carnosine-related antioxidants: a review”. Current Medicinal Chemistry 12 (20): 2293–2315. doi:10.2174/0929867054864796. PMID 16181134. 
  52. ^ a b c “Novel inhibitors of advanced glycation endproducts”. Arch. Biochem. Biophys. 419 (1): 63–79. (2013-03-25). doi:10.1016/j.abb.2003.08.009. PMID 14568010. 
  53. ^ Mizutani, K; Ikeda, K; Yamori, Y (Jul 21, 2000). “Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.”. Biochemical and Biophysical Research Communications 274 (1): 61–7. doi:10.1006/bbrc.2000.3097. PMID 10903896. 
  54. ^ Tang Y (May 2014). “Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling.”. Lab Invest. 94 (5): 503-16. doi:10.1038/labinvest.2014.42. PMID 24614199. https://doi.org/10.1038/labinvest.2014.42. 
  55. ^ Ryoji Nagai, Jun-ichi Shirakawa, Rei-ichi Ohno, Narumi Moroishi, M. Nagai (2013). “Inhibition of AGEs formation by natural products”. Amino acids 46 (2). doi:10.1007/s00726-013-1487-z. 
  56. ^ “N-Acetyl Cysteine Attenuated the Deleterious Effects of Advanced Glycation End-Products on the Kidney of Non-Diabetic Rats”. Cellular Physiology and Biochemistry 40 (3-4). (2016). doi:10.1159/000452574. 
  57. ^ Upadhyay A, Tuenter E, Ahmad R, et al. (2014-08). “Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors.”. Planta Med. 80 (12): 1001-8. doi:10.1055/s-0034-1382949. PMID 25098935. 
  58. ^ “Academic Journals formerly published by NPG”. Nature.com. 2013年11月13日閲覧。
  59. ^ Vasan, S; Zhang, X; Zhang, X; Kapurniotu, A; Bernhagen, J; Teichberg, S; Basgen, J; Wagle, D; Shih, D; Terlecky, I; Bucala, R; Cerami, A; Egan, J; Ulrich, P (Jul 18, 1996). “An agent cleaving glucose-derived protein crosslinks in vitro and in vivo.”. Nature 382 (6588): 275–8. doi:10.1038/382275a0. PMID 8717046. 
  60. ^ Monnier, V. M., Mustata, G. T., Biemel, K. L., Reihl, O., Lederer, M. O., Zhenyu, D. (2005). “Cross-linking of the extracellular matrix by the maillard reaction in aging and diabetes: An update on "a puzzle nearing resolution"”. Annals of the New York Academy of Sciences 1043: 533–544. doi:10.1196/annals.1333.061. PMID 16037276. 
  61. ^ Furber, J.D. (2006). “Extracellular glycation crosslinks: Prospects for removal”. Rejuvenation Research (Elsevier Inc.) 9 (2): 274–278. doi:10.1089/rej.2006.9.274. PMID 16706655. 
  62. ^ Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S (2012-11). “Metformin inhibits advanced glycation end products (AGEs)-induced renal tubular cell injury by suppressing reactive oxygen species generation via reducing receptor for AGEs (RAGE) expression.”. Horm Metab Res. 44 (12): 891-5. doi:10.1055/s-0032-1321878. PMID 22864903. http://www.ncbi.nlm.nih.gov/pubmed/22864903. 
  63. ^ “メトホルミンによる血管保護の機序”. 大日本住友製薬. 2015年9月23日閲覧。
  64. ^ a b “糖酸化反応経路の解明、および糖酸化ストレスのシグナリングとレドックス制御機構の解明 JSPS-RFTF 96L00303”. 日本学術振興会. 2015年10月8日閲覧。
  65. ^ “AGEs（終末糖化物質）を測るには”. AGE測定推進協会. 2015年2月22日閲覧。

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