PARP1とは？ わかりやすく解説

Weblio 辞書 > 辞書・百科事典 > 百科事典 > PARP1の意味・解説 
ウィキペディア
索引トップ ランキング カテゴリー
ウィキペディアウィキペディア

PARP1

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/05/15 09:34 UTC 版)

PARP1（poly [ADP-ribose] polymerase 1）は、ヒトではPARP1遺伝子にコードされる酵素である[5]。NAD+ ADP-ribosyltransferase 1、poly[ADP-ribose] synthase 1などの名称でも知られる。 PARP（英語版）ファミリーの酵素の中で最も豊富に存在し、このファミリーに利用されるNAD+のうち90%をPARP1が占める[6]。PARP1は大部分が細胞核に存在するが、一部は細胞質基質に存在することも報告されている[7]。


出典
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143799 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026496 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ “Poly(ADP-ribose) polymerase-1 in the nervous system”. Neurobiology of Disease 7 (4): 225–39. (August 2000). doi:10.1006/nbdi.2000.0324. PMID 10964595. 
  6. ^ a b “NAD + metabolism: pathophysiologic mechanisms and therapeutic potential”. Signal Transduction and Targeted Therapy 5 (1): 227. (2020). doi:10.1038/s41392-020-00311-7. PMC 7539288. PMID 33028824. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539288/. 
  7. ^ Karpińska, Aneta. “Quantitative analysis of biochemical processes in living cells at a single-molecule level: a case of olaparib–PARP1 (DNA repair protein) interactions”. Analyst. doi:10.1039/D1AN01769A. PMID 34726203. 
  8. ^ Nilov, DK; Pushkarev, SV; Gushchina, IV; Manasaryan, GA; Kirsanov, KI; Švedas, VK (2020). “Modeling of the enzyme-substrate complexes of human poly(ADP-ribose) polymerase 1”. Biochemistry (Moscow) 85 (1): 99–107. doi:10.1134/S0006297920010095. PMID 32079521. 
  9. ^ a b “Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation”. Oxidative Medicine and Cellular Longevity 2012: 321653. (2012). doi:10.1155/2012/321653. PMC 3459245. PMID 23050038. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459245/. 
  10. ^ “Entrez Gene: PARP1 poly (ADP-ribose) polymerase family, member 1”. 2022年5月7日閲覧。
  11. ^ “Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori”. Proceedings of the National Academy of Sciences of the United States of America 106 (47): 19998–20003. (November 2009). Bibcode: 2009PNAS..10619998N. doi:10.1073/pnas.0906753106. PMC 2785281. PMID 19897724. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785281/. 
  12. ^ a b “The comings and goings of PARP-1 in response to DNA damage”. DNA Repair 71: 177–182. (November 2018). doi:10.1016/j.dnarep.2018.08.022. PMC 6637744. PMID 30177435. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637744/. 
  13. ^ “PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility”. Nucleic Acids Research 36 (13): 4454–64. (August 2008). doi:10.1093/nar/gkn403. PMC 2490739. PMID 18603595. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490739/. 
  14. ^ “Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination”. Nucleic Acids Research 31 (17): 4959–64. (September 2003). doi:10.1093/nar/gkg703. PMC 212803. PMID 12930944. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212803/. 
  15. ^ “Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation)”. Nucleic Acids Research 19 (21): 5943–7. (November 1991). doi:10.1093/nar/19.21.5943. PMC 329051. PMID 1945881. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329051/. 
  16. ^ “PARP1 suppresses homologous recombination events in mice in vivo”. Nucleic Acids Research 38 (21): 7538–45. (November 2010). doi:10.1093/nar/gkq624. PMC 2995050. PMID 20660013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995050/. 
  17. ^ “Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease”. Genes & Development 9 (5): 509–20. (March 1995). doi:10.1101/gad.9.5.509. PMID 7698643. 
  18. ^ a b “Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review”. Frontiers in Immunology 8: 1172. (2017). doi:10.3389/fimmu.2017.01172. PMC 5610677. PMID 28974953. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610677/. 
  19. ^ “Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD”. Immunometabolism 2 (3): e200026. (2020). doi:10.20900/immunometab20200026. PMC 7409778. PMID 32774895. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409778/. 
  20. ^ “Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases”. Cells 9 (1): 41. (2019). doi:10.3390/cells9010041. PMC 7017201. PMID 31877876. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017201/. 
  21. ^ “Homology and enzymatic requirements of microhomology-dependent alternative end joining”. Cell Death & Disease 6 (3): e1697. (March 2015). doi:10.1038/cddis.2015.58. PMC 4385936. PMID 25789972. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385936/. 
  22. ^ a b “c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias”. Molecular Cancer Research 13 (4): 699–712. (April 2015). doi:10.1158/1541-7786.MCR-14-0422. PMC 4398615. PMID 25828893. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398615/. 
  23. ^ a b c “Hypomethylation of ETS transcription factor binding sites and upregulation of PARP1 expression in endometrial cancer”. BioMed Research International 2013: 946268. (2013). doi:10.1155/2013/946268. PMC 3666359. PMID 23762867. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666359/. 
  24. ^ a b “Poly (ADP-ribose) polymerase 1 transcriptional regulation: a novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer”. Oncotarget 5 (1): 291–7. (January 2014). doi:10.18632/oncotarget.1549. PMC 3960209. PMID 24448423. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960209/. 
  25. ^ “Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer”. BMC Cance 13: 90. (February 2013). doi:10.1186/1471-2407-13-90. PMC 3599366. PMID 23442605. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599366/. 
  26. ^ “Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma”. Molecular Cancer Research 13 (3): 470–82. (March 2015). doi:10.1158/1541-7786.MCR-14-0337. PMID 25563294. 
  27. ^ “Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining”. Clinical Cancer Research 24 (23): 6001–6014. (December 2018). doi:10.1158/1078-0432.CCR-18-1346. PMID 30087144. 
  28. ^ “PARP expression in germ cell tumours”. Journal of Clinical Pathology 66 (7): 607–12. (July 2013). doi:10.1136/jclinpath-2012-201088. PMID 23486608. 
  29. ^ “Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells”. Oncology Reports 9 (3): 529–32. (2002). doi:10.3892/or.9.3.529. PMID 11956622. 
  30. ^ “Enhanced expression of poly(ADP-ribose) synthetase gene in malignant lymphoma”. American Journal of Hematology 37 (4): 223–7. (August 1991). doi:10.1002/ajh.2830370402. PMID 1907096. 
  31. ^ “Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer”. Annals of Oncology 23 (5): 1156–64. (May 2012). doi:10.1093/annonc/mdr361. PMID 21908496. 
  32. ^ “PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1”. PLOS ONE 9 (12): e115558. (2014). Bibcode: 2014PLoSO...9k5558D. doi:10.1371/journal.pone.0115558. PMC 4272268. PMID 25526641. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272268/. 
  33. ^ “Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence”. Cell Metabolism 27 (3): 529–547. (2018). doi:10.1016/j.cmet.2018.02.011. PMC 6342515. PMID 29514064. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515/. 
  34. ^ “Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase”. Nature 434 (7035): 913–7. (April 2005). Bibcode: 2005Natur.434..913B. doi:10.1038/nature03443. PMID 15829966. 
  35. ^ “Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy”. Nature 434 (7035): 917–21. (April 2005). Bibcode: 2005Natur.434..917F. doi:10.1038/nature03445. PMID 15829967. 
  36. ^ “Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span”. Proceedings of the National Academy of Sciences of the United States of America 89 (24): 11759–63. (December 1992). Bibcode: 1992PNAS...8911759G. doi:10.1073/pnas.89.24.11759. PMC 50636. PMID 1465394. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50636/. 
  37. ^ “Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians”. Journal of Molecular Medicine 76 (5): 346–54. (April 1998). doi:10.1007/s001090050226. PMID 9587069. 
  38. ^ “Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice”. The American Journal of Pathology 162 (5): 1559–69. (May 2003). doi:10.1016/S0002-9440(10)64290-3. PMC 1851180. PMID 12707040. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851180/. 
  39. ^ “PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53”. Oncogene 37 (21): 2793–2805. (May 2018). doi:10.1038/s41388-018-0130-6. PMC 5970015. PMID 29511347. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970015/. 
  40. ^ “A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol”. Nature 519 (7543): 370–3. (March 2015). Bibcode: 2015Natur.519..370S. doi:10.1038/nature14028. PMC 4368482. PMID 25533949. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368482/. 
  41. ^ “Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone”. Proceedings of the National Academy of Sciences of the United States of America 111 (35): 12752–7. (September 2014). Bibcode: 2014PNAS..11112752M. doi:10.1073/pnas.1405005111. PMC 4156740. PMID 25136112. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156740/. 
  42. ^ “Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor”. Oncogene 18 (27): 3954–62. (July 1999). doi:10.1038/sj.onc.1202778. PMID 10435618. 
  43. ^ a b c “Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians”. Rejuvenation Research 10 (2): 191–204. (June 2007). doi:10.1089/rej.2006.0514. PMID 17518695. https://www.researchgate.net/publication/6313423. 
  44. ^ “Poly(ADP-ribosyl)ation in plants”. Trends in Plant Science 16 (7): 372–80. (July 2011). doi:10.1016/j.tplants.2011.03.008. PMID 21482174. 
  45. ^ “Protein ADP-Ribosylation Takes Control in Plant-Bacterium Interactions”. PLOS Pathogens 12 (12): e1005941. (December 2016). doi:10.1371/journal.ppat.1005941. PMC 5131896. PMID 27907213. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131896/. 
  46. ^ a b “PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses”. PLOS Genetics 11 (5): e1005200. (May 2015). doi:10.1371/journal.pgen.1005200. PMC 4423837. PMID 25950582. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423837/. 
  47. ^ a b c “Aprataxin, a novel protein that protects against genotoxic stress”. Human Molecular Genetics 13 (10): 1081–93. (May 2004). doi:10.1093/hmg/ddh122. PMID 15044383. 
  48. ^ “Regulation of protein synthesis in heart muscle. II. Effect of amino acid levels and insulin on ribosomal aggregation”. The Journal of Biological Chemistry 246 (7): 2163–70. (April 1971). doi:10.1016/S0021-9258(19)77203-2. PMID 5555565. 
  49. ^ “Poly(ADP-ribose) polymerase is a B-MYB coactivator”. The Journal of Biological Chemistry 275 (14): 10692–6. (April 2000). doi:10.1074/jbc.275.14.10692. PMID 10744766. 
  50. ^ “The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function”. The Journal of Biological Chemistry 276 (49): 45588–97. (December 2001). doi:10.1074/jbc.M106528200. PMID 11590148. 
  51. ^ “Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions”. The Journal of Biological Chemistry 273 (19): 11839–43. (May 1998). doi:10.1074/jbc.273.19.11839. PMID 9565608. 
  52. ^ a b “Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication”. Nucleic Acids Research 26 (8): 1891–8. (April 1998). doi:10.1093/nar/26.8.1891. PMC 147507. PMID 9518481. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC147507/. 
  53. ^ “XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage”. Molecular and Cellular Biology 18 (6): 3563–71. (June 1998). doi:10.1128/MCB.18.6.3563. PMC 108937. PMID 9584196. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108937/. 
  54. ^ “Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes”. Biochemical and Biophysical Research Communications 311 (3): 702–7. (November 2003). doi:10.1016/j.bbrc.2003.10.053. PMID 14623329. 

[続きの解説]

「PARP1」の続きの解説一覧

急上昇のことば

苜蓿
帝人事件
右近良之
MissAV
カナル
英和和英テキスト翻訳>> Weblio翻訳
英語⇒日本語日本語⇒英語
  
  •  PARP1のページへのリンク

辞書ショートカット

カテゴリ一覧

全て

＋ ビジネス

＋ 業界用語

＋ コンピュータ

＋ 電車

＋ 自動車・バイク

＋ 船

＋ 工学

＋ 建築・不動産

＋ 学問

＋ 文化

＋ 生活

＋ ヘルスケア

＋ 趣味

＋ スポーツ

＋ 生物

＋ 食品

＋ 人名

＋ 方言

＋ 辞書・百科事典

すべての辞書の索引

あいうえお
かきくけこ
さしすせそ
たちつてと
なにぬねの
はひふへほ
まみむめも
やゆよ
らりるれろ
わをん
がぎぐげご
ざじずぜぞ
だぢづでど
ばびぶべぼ
ぱぴぷぺぽ
ＡＢＣＤＥ
ＦＧＨＩＪ
ＫＬＭＮＯ
ＰＱＲＳＴ
ＵＶＷＸＹ
Ｚ
１２３４５
６７８９０
記号

Weblioのサービス

「PARP1」の関連用語

1
植物のPARP1
ウィキペディア小見出し辞書
100% |||||

2
DNA修復遺伝子プロモーター
ウィキペディア小見出し辞書
70% |||||

3
ADPリボシル化
ウィキペディア小見出し辞書
56% |||||

4
DNA修復タンパク質との相互作用
ウィキペディア小見出し辞書
52% |||||

5
DNA修復
ウィキペディア小見出し辞書
32% |||||

6
癌におけるダウンレギュレーションとアップレギュレーション
ウィキペディア小見出し辞書
32% |||||

7
基礎研究
ウィキペディア小見出し辞書
30% |||||

8
DNA損傷への応答
ウィキペディア小見出し辞書
18% |||||

9
稀なヒストン修飾
ウィキペディア小見出し辞書
16% |||||

10
クロマチンリモデリング
ウィキペディア小見出し辞書
14% |||||

PARP1のお隣キーワード

PARKING OUT

PARKS パークス

PARKSIDE JAM

PARLOG

PARM

PARM1地雷

PARP1

PARQUET

PARRY

PART TIMEガンジー

PARTNER

PARTNER (名香智子の漫画)

PARTNER (甲斐よしひろのアルバム)

検索ランキング

   

 英語⇒日本語
日本語⇒英語		    


PARP1のページの著作権
Weblio 辞書 情報提供元は 参加元一覧 にて確認できます。

   
ウィキペディアウィキペディア
All text is available under the terms of the GNU Free Documentation License.
この記事は、ウィキペディアのPARP1 (改訂履歴)の記事を複製、再配布したものにあたり、GNU Free Documentation Licenseというライセンスの下で提供されています。 Weblio辞書に掲載されているウィキペディアの記事も、全てGNU Free Documentation Licenseの元に提供されております。

©2024 GRAS Group, Inc.RSS