亜鉛欠乏症とは？ わかりやすく解説

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亜鉛欠乏症

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/11/09 01:32 UTC 版)

亜鉛欠乏症（あえんけつぼうしょう）は、亜鉛欠乏によって生じる微量栄養素の欠乏症で、「亜鉛欠乏の臨床症状」と「血清亜鉛値」によって確定診断が行われる。日本人は潜在的に亜鉛が不足気味であるとの報告がある[1]。


出典
  1. ^ a b 倉澤隆平 ほか:長野県北御牧村村民の血清亜鉛濃度の実態.Biomed Res Trace Elements, 16:61-65(2005)
  2. ^ a b 日本臨床栄養学会雑誌 38(2):104-148,2016「亜鉛欠乏症の診療指針 (PDF) 」
  3. ^ Kinomoto T et al: Effect of polaprezinc on morphological change of the tongue in zinc-deficient rats. J Oral Pathol Med, 39:617-623(2005)
  4. ^ a b 池田 稔 他:味覚異常と亜鉛。治療,87(別冊)：21-26(2005)
  5. ^ Zheng J et al: Differential effects of GATA-1on proliferation and differentiation of erythroid lineage cells. Blood, 107:520-527(2006)
  6. ^ 西山宗六：スポーツと貧血-亜鉛欠乏は溶血を起こさせる-. 診断と治療,4:2035-2038(2006)
  7. ^ a b Fukushima T et al: Zinc deficiency anemia and effects of zinc therapy in maintenance hemodialysis patients. Therapeutic Apheresis Dialysis, 13:213-219(2009)
  8. ^ 児玉浩子: 栄養と成長. 小児内科, 35: 386-389 (2003)
  9. ^ a b Kaji M:Zinc in endocrinology.Int Pediatr,16:131-137(2001)
  10. ^ a b c Hamza RT, Hamed AI, Sallam MT: Effect of zinc supplementation on growth hormone insulin growth factor axis in short Egyptian children with zinc deficiency. Italian J Pediatr, 38: 21 (2012)
  11. ^ 児玉浩子、小川英伸、元山華穂子、佐藤恭弘: 亜鉛欠乏症－乳幼児から成人まで－. 小児科, 55: 341-348 (2014)
  12. ^ Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta Y, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S: Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. J Clin Invest, 122: 722-732 (2012)
  13. ^ Inoue Y, Hasegawa S, Ban S, Yamada T, Date Y, Mizutani H, Nakata S, Tanaka M, Hirashima N: ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation. J Biol Chem, 289: 21451-21462 (2014)
  14. ^ 川村龍吉、日本臨床 74(7):1144-1149(2016)
  15. ^ a b c Kumari D, Nair N, Bedwal RS: Dietary zinc deficiency and testicular apoptosis. Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health, Watson RR ed, Elsevier Inc, 341-353 (2015)
  16. ^ a b Kumari D, Nair N, Bedwal RS: Protein carbonyl, 3β- and 17β-hydroxysteroid dehydrogenases in testes and serum FSH, LH and testosterone levels in zinc deficient Wister rats. Biofactors, 38: 234-239 (2012)
  17. ^ Ali H, Ahmed M, Baig M, Ali M: Relationship of zinc concentrations in blood and seminal plasma with various semen parameters in infertile subjects. Pak J Med Sci, 23: 111-114 (2007)
  18. ^ Taravati A, Tohidi F: Association between seminal plasma zinc level and asthenozoospermia: a meta-analysis study. Andrologia, (Nov 5, 2015)
  19. ^ Omu AE, Al-Azemi MK, Al-Maghrebi M, Mathew CT, Omu FE, Kehinde EO, Anim JT, Oriowo MA, Memon A: Molecular basis for the effects of zinc deficiency on spermatogenesis: An experimental study in the Sprague-dawley rat model. Indian J Urol, 31: 57-64 (2015)
  20. ^ Elmes ME, Jones JG: Ultrastructural changes in the small intestine of zinc deficient rats. J Pathol, 130: 37-43 (1980)
  21. ^ Koo SI, Turk DE: Effect of zinc deficiency on the ultrastructure of the pancreatic acinar cell and intestinal epithelium in the rat. J Nutr, 107: 896-908 (1977)
  22. ^ Levenson CW: Zinc regulation of food intake: new insights on the role of neuropeptide Y. Nutr Rev, 61: 247-249 (2003)
  23. ^ Van Wouwe JP: Clinical and laboratory diagnosis of acrodermatitis enteropathica. Eur J Pediatr, 149: 2-8 (1989)
  24. ^ Southon S, Gee J, Bayliss CE, Wyatt GM, Horn N, Johnson IT: Intestinal microflora, morphology and enzyme activity in zinc-deficient and Zn supplemented rats. Br J Nutr, 55: 603-611 (1986)
  25. ^ Hoque KM, Sarker R, Guggino SE, Tse C-M: A new insight into pathophysiological mechanisms of zinc in diarrhea. Ann N Y Acad Sci, 1165: 279-284 (2009)
  26. ^ Zhang B, Guo Y: Supplemental zinc reduced intestinal permeabilityby enhancing occluding and zonula occludens protein-1 (ZO-1) expression in weaning piglets. Br J Nutr, 102: 687-693 (2009)
  27. ^ Roy SK, Behrens RH, Haider R, Akramuzzaman SM, Mahalanabis D, Wahed MA, Tomkins AM: Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhoea syndrome. J Pediatr Gastroenterol Nutr, 15: 289-293 (1992)
  28. ^ a b Prasad AS: Zinc in human health: effect of zinc on immune cells. Mol Med, 14: 353-357 (2008)
  29. ^ Liu MJ, Bao S, Galvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL: ZIP8 regulates host defence through zinc-mediated inhibition of NF-kappaB. Cell Reports, 3: 386-400 (2013)
  30. ^ a b Yamaguchi M: Role of nutritional zinc in the prevention of osteoporosis. Mol Cell Biochem, 338: 241-254 (2010)
  31. ^ Blobe GC, Schiemann WP, Lodish HF: Role of transforming growth factor β in human disease. New Engl J Med, 342: 1350-1358 (2000)
  32. ^ Wintergerst ES, Maggini S, Hornig DH: Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab, 51: 301-323 (2007)
  33. ^ 田中芳明、石井信二、浅桐公男: エビデンスに基づく病態別経腸栄養法〜病態別経腸栄養剤の選び方と使い方〜 褥瘡. 静脈経腸栄養, 27: 703-710 (2012)
  34. ^ Lansdown ABG, Mirastschijski U, Stubbs N, Scanlon E, Ågren MS: Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound Repair Regen, 2007; 15: 2-16 (2007)
  35. ^ Prasad AS: Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J Infect Dis,182(Suppl 1): S62-S68 (2000)
  36. ^ Shankar AH, Prasad AS: Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr, 68(2 Suppl): 447S-463S (1998)
  37. ^ Ukita T, Oidov B, Kawada E, Ohyama Y, Morita T, Tamura J: Serum zinc deficiency increases susceptibility to infection in older patients who have long-term hospitalizations. Biomed Res Trace Elements, 19: 260-264 (2008)
  38. ^ Ikeda M et al: Taste disorders: a survey of the examination methods and treatments used in Japan. Acta Oto-Laryngol, 125:1203-1210(2005)
  39. ^ 池田稔：味覚障害と亜鉛,87(別冊):21-26(2005)
  40. ^ 冨田寛：薬剤性味覚障害.味覚障害の全貌,冨田寛(著),診断と治療社,316-345(2011)
  41. ^ 稲毛康司：まれでない亜鉛欠乏-皮膚炎との鑑別,小児内科.44:131-134(2012)
  42. ^ 岡田淳 ほか:褥瘡患者における血清亜鉛の動態.微量金属代謝,1:43-47(1975)
  43. ^ a b 花田勝美 ほか:2,3皮膚疾患に対する亜鉛療法の試み. 西日本皮膚科,44:202-207(1982)
  44. ^ a b Tasaki et al: Analyses of serum copper and zinc levels and copper/zinc ratios in skin disease Dermatol,20:21-24(1993)
  45. ^ Kil MS et al: Analysis of serum zinc and copper concentrations in hair loss.Ann Dermatol,25:405-409(2013)
  46. ^ a b Park H et al: The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata patients who had a low serum zinc level. Ann Dermatol,21:142-146(2009)
  47. ^ a b Nakamura T et al: Mild to moderate zinc deficiency in short children :effect of zinc supplementation on linear growth velocity. J Pediatr, 123:65-69(1993)
  48. ^ a b Kaji M et al: Studies to determine the usefulness of the zinc clearance test to diagnose marginal zinc deficiency and the effects of oral zinc supplementation for short children. J Am Coll Nutr, 17:388-391(1998)
  49. ^ 加賀文彩 ほか:低身長児における血清亜鉛値の検討とGH長期使用患者におけるGH、亜鉛併用療法の効果、研究年報/成長科学協会,31:101-105(2008)
  50. ^ 八木澤裕美 ほか:成長障害および低身長児における血清亜鉛値の検討.日本小児栄養消化器学会雑誌,26(Supple):156(2012)
  51. ^ Russell RM et al: Vitamin and trace mineral deficiency and excess. MINERALS. ZINC. Harrison’s Principles of Internal Medicine, Kasper DL, Franci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J eds, 19th Ed., McGraw Hill, New York, 96e9-96e-10(2015)
  52. ^ Kanabrocki EL et al: Circadian characteristic of serum calcium, magnesium and eight trace elements and of their metallo-moieties in urine of healthy middle-aged men. Clin Ter, 159:329-346(2008)
  53. ^ 井上彩子 ほか: 亜鉛の日内変動についての検討.医学検査,61:748-752(2012)
  54. ^ 堀内成人 ほか:血清亜鉛値の臨床的意義の2,3の検討.日本臨床,28:2160-2164(2005)
  55. ^ McMillan EM et al: Clinical significance of diurnal variation in the estimation of plasma zinc. Clin Exp Dermatol, 7: 629-631(1982)
  56. ^ a b 柳澤裕之:亜鉛欠乏症の臨床.日本医師会雑誌,127:261-268(2002), NAID 10010520923
  57. ^ a b 野本昭三ほか:血清亜鉛値による亜鉛欠乏症検出システムの現況:その欠落部への提言.Biomed Res Trace Elements,14:335-337(2003), NAID 10027904430
  58. ^ Adeniyi FA et al: The effect of zinc deficiency on alkaline phosphatase (EC3.1.3.1) and its isoenzymes. Br J Nutr, 43:561-569(1980)
  59. ^ 神田裕三 ほか:亜鉛欠乏症-血清alkaline phosphataseによる早期診断の検討-.JJPEN, 7:227-231(1985)
  60. ^ 長谷川道子 ほか:経過中に小球性貧血をきたした低亜鉛母乳による亜鉛欠乏症の1例.臨床皮膚科,69:742-745(2015)
  61. ^ Kasarskis et al:Serum alkaline phosphatase after treatment of zinc deficiency in humans.Am J Clin Nutr,33:2609-2612(1980)
  62. ^ Weismann K et al:Serum alkaline phosphatase and serum zinc levels in the diagnosis and exclusion of zinc deficiency in man.Am J Clin Nutr,41:1214-1219(1985)
  63. ^ 文部科学省:日本食品標準成分表2015年版(七訂)
  64. ^ 児玉浩子 ほか:欠乏症による皮膚病変-ビオチン欠乏症と亜鉛欠乏症.MB Derma, 236:146-152(2015)
  65. ^ Nishi Y et al: Transient partial growth hormone deficiency due to zinc deficiency. J Am Coll Nutr, 8:93-97(1989)
  66. ^ Shaikhkhalil AK: Enteral zinc supplementation and growth in extremely-low-birth-weight infants with chronic lung disease.J Pediatr Gastroenterol Nutr,58:183-187(2014)
  67. ^ Brown KH, Peerson JM, Rivera J, Allen LH: Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 75: 1062-1071 (2002)
  68. ^ 嶋岡正利: 低亜鉛母乳による獲得性腸性肢端皮膚炎. 皮膚病診療, 24: 865-868 (2002)
  69. ^ 中山文子、小田裕次郎、瀬戸山 充、尾上康弘: 低亜鉛母乳による腸性肢端皮膚炎. 皮膚病診療, 25: 303-306 (2003)
  70. ^ 中村吏江、鼻岡佳子、森本謙一、辻 徹郎: 超早産児に生じた腸性肢端皮膚炎の1例. 臨床皮膚科, 64: 287-290 (2010), doi:10.11477/mf.1412102547
  71. ^ a b Topal AA, Dhurat RS, Nayak CS: Zinc responsive acrodermatitis in nephrotic syndrome: A rare presentation. Indian J Dermatol Venereol Leprol, 78: 122-123 (2012)
  72. ^ a b Shahsavari D, Ahmed Z, Karikkineth A, Williams R, Zigel C: Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. J Community Hosp Intern Med Perspect, 4: 24707 (2014)
  73. ^ a b 米良ゆかり、児浦純義、橋口貴樹、寺﨑健治朗、米良健太郎、金蔵拓郎、神崎 保: 膵癌全摘術後に発症した腸性肢端皮膚炎の1例. 西日本皮膚科, 69: 28-30 (2007), doi:10.2336/nishinihonhifu.69.28
  74. ^ 吉村和弘、名嘉眞武国、安元慎一郎、橋本 隆: 後天性亜鉛欠乏による腸性肢端皮膚炎. 皮膚病診療, 30: 47-50 (2008)
  75. ^ 田村利和、福田 洋、岡田憲三、川人幹也、国友一史、藤田博茂、大和秀夫、嵩原裕夫、古味信彦: 高カロリー輸液施行中に亜鉛欠乏症をきたしたクローン病の3例. 大腸肛門誌, 37: 132-137 (1984), doi:10.3862/jcoloproctology.37.132
  76. ^ 佐伯圭介、西本正賢、山本信二、沼原利彦、佐々木和江、高岩 堯: 中心静脈栄養施行中のクローン病患者に生じた亜鉛欠乏症候群. 臨床皮膚科, 47: 675-677 (1993), doi:10.11477/mf.1412900956
  77. ^ Maverakis E, Fung MA, Lynch PJ, Draznin M, Michael DJ, Ruben B, Fazel N: Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol, 56:116-124 (2007)
  78. ^ Kumar P, Lal NR, Mondal AK, Mondal A, Gharami RC, Maiti A: Zinc and skin: A brief summary. Dermatology Online J, 18: 1 (2012)
  79. ^ 浅野道子、奥田諭吉、平野国美、山岡 孝、鶴嶋陽子、曽根博仁、小川雅士、伊坂正明、水谷正一、朝倉由加利、鈴木誠司、坂内千恵子、川上 康、小田原雅人、松島照彦、川井紘一、山口高史、山下亀次郎: 重篤な亜鉛欠乏症を呈した膵性糖尿病の1症例. 糖尿病, 38: 517-522 (1995), doi:10.11213/tonyobyo1958.38.517
  80. ^ 堀 仁子、橋本喜夫、飯塚 一: 亜鉛欠乏の関与が考えられた再発性アフタ性口内炎. 臨床皮膚科, 61: 880-882 (2007), doi:10.11477/mf.1412101783
  81. ^ Orbak R, Cicek Y, Tezel A, Dogru Y: Effects of zinc treatment in patients with recurrent aphthous stomatitis. Dental Mater J, 22: 21-29 (2003)
  82. ^ Sharquie KE, Noaimi AA, Shwail ER. Oral zinc sulphate in treatment of alopecia areata (Double blind; Cross-over study). J Clin Exp Dermatol Res, 3: 2 (2012)
  83. ^ Betsy A, Binitha MP, Sarita S: Zinc deficiency associated with hypothyroidism: An overlooked cause of severe alopecia. Int J Trichol, 5: 40-42 (2013)
  84. ^ Alhaj E, Alhaj N, Alhaj NE: Diffuse alopecia in a child due to dietary zinc deficiency. Skinmed, 6: 199-200 (2007)
  85. ^ Mahajan SK, Prasad AS, Lambujon J, Abbasi AA, Briggs WA, McDonald FD: Improvement of uremic hypogeusia by zinc: a double-blind study. Am J Clin Nutr, 33: 1517-1521 (1980)
  86. ^ Heckmann SM, Hujoel P, habiger S, Friess W, Wichmann M, Heckmann JG, Hummel T: Zinc gluconate in the treatment of dysgeusia－a randomized clinical trial. J Dent Res, 84: 35-38 (2005)
  87. ^ 池田 稔、黒野祐一、井之口 昭、武田憲昭、愛場庸雅、野村泰之、阪上雅史: プラセボ対照無作為化試験による亜鉛欠乏性または特発性味覚障害219例に対するポラプレジンク投与の臨床的検討. 日耳鼻, 116: 17-26 (2013), doi:10.3950/jibiinkoka.116.17
  88. ^ 阪上雅史、黒野祐一、井之口 昭、武田憲昭、愛場庸雅、任 智美、池田 稔: 味覚障害患者に対する24週間の亜鉛内服治療における味覚機能検査と自覚症状の経時的推移および効果予測因子. 日耳鼻, 117: 1093-1101 (2014), doi:10.3950/jibiinkoka.117.1093
  89. ^ Nishiyama S, Inomoto T, Nakamura T, Higashi A, Matsuda I: Zinc status relates to hematological deficits in women endurance runners. J Am Coll Nutr, 15: 359-363 (1996)
  90. ^ 瀬崎良三、中島 貴、杉浦泰浩、田中章仁: 亜鉛の経口投与が維持透析患者の貧血に及ぼす効果. Therapeutic Research, 28: 1711-1715 (2007)
  91. ^ Kobayashi H, Abe M, Okada K, Tei R, Maruyama N, Kikuchi F, Higuchi T, Soma M: Oral zinc supplementation reduces the erythropoietin responsiveness index in patients on hemodialysis. Nutrients, 7: 3783-3795 (2015)
  92. ^ Antoniou LD, Shalhoub RJ, Sudhakar T, Smith JC: Reversal of uraemic impotence by zinc. Lancet, 310: 895-898 (1977)
  93. ^ a b Mahajan SK, Abbasi AA, Prasad AS, Rabbani P, Briggs WA, McDonald FD: Effect of oral zinc therapy on gonadal function in hemodialysis patients. Ann Intern Med, 97: 357-361 (1982)
  94. ^ Zhao J, Dong X, Hu X, Long Z, Wang L, Liu Q, Sun B, Wang Q, Wu Q, Li L: Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis. Sci Rep,6:22386(2016)
  95. ^ Mahdaviroshan M, Golzarand M, Taramsari MR, Mahdaviroshan M: Effect of zinc supplementation on serum zinc and calcium levels in postmenopausal osteoporotic women in Tabriz, Islamic Republic of Iran. East Mediterr Health J, 19: 271-275 (2013)
  96. ^ Fung EB, Kwiatkowski JL, Huang JN, Gildengorin G, King JC, Vichinsky EP: Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr, 98: 960-971 (2013)
  97. ^ Sadighi A, Roshan MM, Moradi A, Ostadrahimi A: The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones. Saudi Med J, 29: 1276-1279 (2008)
  98. ^ Prasad AS, Beck FWJ, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJ: Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr, 85: 837-844 (2007)
  99. ^ 和田恵子、中川 元、奈須康子、松井秀司、武田さおり、松田光展、武井理子、牧野道子、武智信幸、赤星恵子、椎木俊秀、舟橋満寿子、鈴木康之: 重症心身障害児(者)に対するポラプレジンクによる亜鉛補充療法の経験. 日本重症心身障害学会誌, 36: 503-507 (2011)
  100. ^ Barnett JB, Dao MC, Hamer DH, Kandel R, Brandeis G, Wu D, Dallal GE, Jacques PF, Schreiber R, Kong E, Meydani SN: Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr, 103: 942-951 (2016)
  101. ^ a b Katayama K, Saito M, Kawaguchi T, Endo R, Sawara K, Nishiguchi S, Kato A, Kohgo H, Suzuki K, Sakaida I, Ueno Y, Habu D, Ito T, Moriwaki H, Suzuki K: Effect of zinc on liver cirrhosis with hyperammonemia: A preliminary randomized, placebo-controlled double-blind trial. Nutrition, 30: 1409-1414 (2014)
  102. ^ Reding P, Duchateau J, Bataille C: Oral zinc supplementation improves hepatic encephalopathy. Lancet, 2: 493-495 (1984)
  103. ^ Marchesini G, Fabbri A, Bianchi G, Brizi M, Zoli M: Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced cirrhosis. Hepatology, 23: 1084-1092 (1996)
  104. ^ a b Takuma Y, Nouso K, Makino Y, Hayashi M, Takahashi H: Clinical trial: oral zinc in hepatic encephalopathy. Aliment Pharmacol Ther, 32: 1080-1090 (2010)
  105. ^ 高口浩一、水川 翔、高嶋志保、泉川孝一、石川茂直、田岡伸朗、馬場伸介、三好正嗣、和唐正樹、妹尾知典、稲葉知己、永野拓也、河合公三: 肝性脳症を伴う肝硬変患者における亜鉛投与の効果と有効投与量の検討. 亜鉛栄養治療, 3: 62-71 (2013)
  106. ^ Riggio O, Ariosto F, Merli M, Caschera M, Zullo A, Balducci G, Ziparo V, Pedretti G, Fiaccadori F, Bottari E, Capocaccia L: Short-term oral zinc supplementation does not improve chronic hepatic encephalopathy. Results of a double-blind crossover trial. Dig Dis Sci, 36: 1204-1208 (1991)
  107. ^ 日本消化器病学会: 肝硬変診療ガイドライン2015 (改訂第2版) (PDF) , 南江堂, (2015)
  108. ^ Blei AT, Cordoba J, and The Practice Parameters Committee of the American College of Gastroenterology: Practice Guidelines. Hepatic Encephalopathy. Am J Gastroenterol, 96: 1968-1976 (2001)
  109. ^ Sturniolo GC, Molokhia MM, Shields R, Turnberg LA: Zinc absorption in Crohn’s disease. Gut, 21: 387-391 (1980)
  110. ^ 高松正剛、土細工利夫、廣岡大司、杉之下与志樹、喜多竜一、木村 達、國立裕之、大崎往夫、友野尚美: 慢性肝疾患に対する抗線維化療法－亜鉛含有製剤による検討－. 肝胆膵, 48: 659-666 (2004)
  111. ^ 高橋正彦、斎藤英胤: 経口亜鉛含有製剤による慢性肝疾患に対する抗線維化効果. 消化器科, 44: 636-641 (2007)
  112. ^ Katayama K, Sakakibara M, Imanaka K, Ohkawa K, Matsunaga T, Naito M, Ito T: Effect of zinc supplementation in patients with type C liver cirrhosis. Open J Gastroenterol, 1: 28-34 (2011)
  113. ^ Matsuoka S, Matsumura H, Nakamura H, Oshiro S, Arakawa Y, Hayashi J, Sekine N, Nirei K, Yamagami H, Ogawa M, Nakajima N, Amaki S, Tanaka N, Moriyama M: Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis. J Clin Biochem Nutr, 45: 292-303 (2009)
  114. ^ Hashemipour M, Kelishadi R, Shapouri J, Sarrafzadegan N, Amini M, Tavakoli N, Movahedian-Attar A, Mirmoghtadaee P, Poursafa P: Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children. Hormones, 8: 279-285 (2009)
  115. ^ Khan MI, Siddique KU, Ashfaq F, Ali W, Reddy HD, Mishra A: Effect of high-dose zinc supplementation with oral hypoglycemic agents on glycemic control and inflammation in type-2 diabetic nephropathy patients. J Nat Sci Biol Med, 4: 336-340 (2013)
  116. ^ Maruthur NM, Clark JM, Fu M, Linda Kao WH, Shuldiner AR: Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish. Diabetologia, 58: 295-303 (2015)
  117. ^ Chu A, Foster M, Hancock D, Bell-Anderson K, Petocz P, Samman S: TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus. Genes Nutr, 10: 440 (2015)
  118. ^ Parham M, Amini M, Aminorroaya A, Heidarian E: Effect of zinc supplementation on microalbuminuria in patients with type 2 diabetes: A double blind, randomized, placebo-controlled, cross-over trial. Rev Diabet Stud, 5: 102-109 (2008)
  119. ^ Roussel AM, Kerkeni A, Zouari N, Mahjoub S, Matheau J-M, Anderson RA: Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. J Am Coll Nutr, 22: 316-321 (2003)
  120. ^ Faure P, Benhamou PY, Perard A, Halimi S, Roussel AM: Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation. Eur J Clin Nutr, 49: 282-288 (1995)
  121. ^ Heidarian E, Amini M, Parham M, Aminorroaya A: Effect of zinc supplementation on serum homocysteine in type 2 diabetic patients with microalbuminuria. Rev Diabet Stud, 6: 64-70 (2009)
  122. ^ Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi RLDK, Constantine GR, atulanda P: Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabet Metab Synd, 4: 13 (2012)
  123. ^ Capdor J, Foster M, Petocz P, Samman S: Zinc and glycemic control: A meta-analysis of randomized placebo controlled supplementation trials in humans. J Trace Elements Med Biol, 27: 137-142 (2013)
  124. ^ El Dib R, Gameiro OLF, Ogata MSP, Módolo NSP, Braz LG, Jorge EC, do Nascimento Junior P, Beletate V: Zinc supplementation for the prevention of type 2 diabetes mellitus in adults with insulin resistance (Review). Cochrane Library, Issue 5 (2015)
  125. ^ Brignola C, Belloli C, De Simone G, Evangelisti A, Parente R, Mancini R, Iannone P, Mocheggiani E, Fabris N, Morini MC, Licastro F: Zinc supplementation restores plasma concentrations of zinc and thymulin in patients with Crohn’s disease. Aliment Pharmacol Ther, 7: 275-280 (1993)
  126. ^ van de Wal Y, van de Sluys A, Verspaget HW, Mulder TPJ, Griffioen G, van Tol EAF, Peña AS, Lamers CBHW: Effect of zinc therapy on natural killer cell activity in inflammatory bowel disease. Aliment Pharmacol Ther, 7: 281-286 (1993)
  127. ^ Belluzzi A, Brignola C, Campieri M, Gionchetti P, Rizzello F, Boschi S, Cunanne S, Miglioli M, Barbara L: Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn’s disease. Aliment Pharmacol Ther, 8: 127-130 (1994)
  128. ^ 戸田敦子、指尾宏子、福田能啓、奥井雅憲、柏原 渉、殿勝康司、澤田幸男、田村和民、下山 孝: クローン病患者の血清亜鉛濃度および病勢指標の検討. 消化と吸収, 20: 17-20 (1997)
  129. ^ Sturniolo GC, Di Leo V, Ferronato A, D’Odorico A, D’Incà R: Zinc supplementation tightens “leaky gut” in Crohn’s disease. Inflammatory Bowel Dis, 7: 94-98 (2001)
  130. ^ Cragg RA, Phillips SR, Piper JM, Varma JS, Campbell FC, Mathers JC, Ford D: Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation. Gut, 54: 469-478 (2005)
  131. ^ Chevalier CA, Liepa G, Murphy MD, Suneson J, VanBeber AD, Gorman MA, Cochran C: The effects of zinc supplementation on serum zinc and cholesterol concentrations in hemodialysis patients. J Ren Nutr, 12: 183-189 (2002)
  132. ^ Pakfetrat M, Shahroodi JR, Zolgadr AA, Larie HA, Nikoo MH, Malekmakan L: Effects of zinc supplement on plasma homocysteine level in end-stage renal disease patients: a double-blind randomized clinical trial. Biol Trace Elem Res, 153: 11-15 (2013)
  133. ^ El-Shazly AN, El-Hady Ibrahim SA, El-Mashad GM, Sabry JH, Sherbini NS: Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients. Int J Nephrol Renovasc Dis, 8: 159-163 (2015)
  134. ^ a b 清水教一、藤原順子、山口之利、大西 眞、佐藤真理、児玉浩子、香坂隆夫、藤澤知雄、乾 あやの、玉井 浩、位田 忍、伊藤 進、伊藤道徳、堀池典生、原田 大、佐田通夫、芳野 信、青木継稔: 本邦におけるWilson病に対する酢酸亜鉛製剤(NPC-02)の有効性と安全性に関する検討. 日本先天代謝異常学会雑誌, 24: 71-80 (2008)
  135. ^ Yuzbasiyan-Gurkan V, Brewer GJ, Abrams GD, Main B, Giacherio D: Treatment of Wilson’s disease with zinc. V. Changes in serum levels of lipase, amylase, and alkaline phosphatase in patients with Wilson’s disease. J Lab Clin Med, 114: 520-526 (1989)
  136. ^ da Silva-Júnior FP, Machado AAC, Lucato LT, Cançado ELR, Barbosa ER: Copper deficiency myeloneuropathy in a patient with Wilson disease. Neurology, 76: 1673-1674 (2011)
  137. ^ Cortese A, Zangaglia R, Lozza A, Piccolo G, Pacchetti C: Copper deficiency in Wilson’s disease: peripheral neuropathy and myelodysplastic syndrome complicating zinc treatment. Mov Disord, 26: 1361-1362 (2011)
  138. ^ Cortese A, Zangaglia R, Lozza A, Piccolo G, Pacchetti C: Monitoring late complications of zinc treatment in Wilson’s disease. Reply to the letter: copper deficiency in Wilson’s disease: an avoidable complication of treatment. Mov Disord, 26: 2449-2450 (2011)
  139. ^ Porter KG, McMaster D, Elmes ME, Love AHG: Anaemia and low serum-copper during zinc therapy. Lancet, 2: 774 (1977)
  140. ^ Prasad AS, Brewer GJ, Schoomaker EB, Rabbani P: Hypocupremia induced by zinc therapy in adults. JAMA, 240: 2166-2168 (1978)
  141. ^ Patterson WP, Winkelmann M, Perry MC: Zinc-induced copper deficiency: Megamineral sideroblastic anemia. Ann Intern Med, 103: 385-386 (1985)
  142. ^ Simon SR, Branda RF, Tindle BH, Burns SL: Copper deficiency and sideroblastic anemia associated with zinc ingestion. Am J Hematol, 28: 181-183 (1988)
  143. ^ Hoffman HN, Phyliky RL, Fleming CR: Zinc-induced copper deficiency. Gastroenterology, 94: 508-512 (1988)
  144. ^ Forman WB, Sheehan D, Cappelli S, Coffman B: Zinc abuse—An unsuspected cause of sideroblastic anemia.West J Med,152:190-192(1990)
  145. ^ Gyorffy EJ, Chan H: Copper deficiency and microcytic anemia resulting from prolonged ingestion of over-the-counter zinc. Am J Gastroenterol, 87: 1054-1055 (1992)
  146. ^ Summerfield AL, Steinberg FU, Gonzalez JG: Morphologic findings in bone marrow precursor cells in zinc-induced copper deficiency anemia. Am J Clin Pathol, 97: 665-668 (1992)
  147. ^ a b Crofton RW, Gvozdanovic D, Gvozdanovic S, Khin CC, Brunt PW, Mowat NAG, Aggett PJ: Inorganic zinc and the intestinal absorption of ferrous iron. Am J Clin Nutr, 50: 141-144 (1989)
  148. ^ Yadrick MK, Kenney MA, Winterfeldt EA: Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr, 49: 145-150 (1989)
  149. ^ Samman S, Roberts DCK: The effect of zinc supplements on lipoproteins and copper status. Atherosclerosis, 70: 247-252 (1988)

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