バイカレイン
バイカレイン
(Baicalein から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/01/17 10:10 UTC 版)
バイカレイン（英: baicalein）は、コガネバナから単離されたフラボンのひとつ。ソリザヤノキでも報告されている。この化合物は、バイカリンのアグリコンである。
- ^ Liao, Jyh-Fei; Wang, Hui-Hung; Chen, Ming-Chih; Chen, Chien-Chih; Chen, Chieh-Fu (1998-08). “Benzodiazepine Binding Site-Interactive Flavones from Scutellaria baicalensis Roots” (英語). Planta Medica 64 (06): 571–572. doi:10.1055/s-2006-957517. ISSN 0032-0943.
- ^ a b Liao, Jyh-Fei; Hung, Wen-Yuan; Chen, Chieh-Fu (2003-03). “Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice” (英語). European Journal of Pharmacology 464 (2-3): 141–146. doi:10.1016/S0014-2999(03)01422-5.
- ^ Awad, R.; Arnason, J.T.; Trudeau, V.; Bergeron, C.; Budzinski, J.W.; Foster, B.C.; Merali, Z. (2003-01). “Phytochemical and biological analysis of Skullcap (Scutellaria lateriflora L.): A medicinal plant with anxiolytic properties” (英語). Phytomedicine 10 (8): 640–649. doi:10.1078/0944-7113-00374.
- ^ Deschamps JD, Kenyon VA, Holman TR (June 2006). “Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases”. Bioorg. Med. Chem. 14 (12): 4295–301. doi:10.1016/j.bmc.2006.01.057. PMID 16500106.
- ^ Hsieh CJ, Hall K, Ha T, Li C, Krishnaswamy G, Chi DS (2007). “Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway”. Clin Mol Allergy 5 (1): 5. doi:10.1186/1476-7961-5-5. PMC 2206049. PMID 18039391.
- ^ Yi-Ling Lin, Rong-Jyh Lin, Kuo-Pyng Shen, Zen-Kong Dai, Ing-Jun Chen, Jiunn-Ren Wu, Bin-Nan Wu, Baicalein, isolated from Scutellaria baicalensis, protects against endothelin-1-induced pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression, Journal of Ethnopharmacology, Volume 138, Issue 2, 18 November 2011, Pages 373-381, ISSN 0378-8741, 10.1016/j.jep.2011.09.014. (http://www.sciencedirect.com/science/article/pii/S0378874111006842)
- ^ Xiong Z, Jiang B, Wu PF, et al. (2011). “Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade”. Biol. Pharm. Bull. 34 (2): 253–9. doi:10.1248/bpb.34.253. PMID 21415537.
- ^ Si Dayong, Wang Y, Zhou Y-H, Guo Y, Wang J, Zhou H, Li Z-S, Fawcett JP (March 2009). “Mechanism of CYP2C9 inhibition by flavones and flavonols”. Drug Metabolism and Disposition 37 (3): 629–34. doi:10.1124/dmd.108.023416. PMID 19074529.
- ^ Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M, Giralt E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorganic and Medicinal Chemistry. 2008 Aug 1;16(15):7516-24. PMID 18650094
- ^ “Iron-binding and anti-Fenton properties of baicalein and baicalin”. Journal of inorganic biochemistry 103 (3). (2009). doi:10.1016/j.jinorgbio.2008.11.003. PMC 2659571. PMID 19108897.
- ^ Li Y, Zhao J, Hölscher C (August 2017). “Therapeutic Potential of Baicalein in Alzheimer's Disease and Parkinson's Disease”. CNS Drugs 31 (8): 639–652. doi:10.1007/s40263-017-0451-y. PMID 28634902.
- ^ “Ameliorative effects of baicalein on an amyloid-β induced Alzheimer's disease rat model: a proteomics study”. Curr Alzheimer Res 11 (9): 869–81. (2014). PMID 25274114.
[続きの解説]
「バイカレイン」の続きの解説一覧
- 1 バイカレインとは
- 2 バイカレインの概要
- 3 配糖体
- Baicaleinのページへのリンク
