O-GlcNAcとは？ わかりやすく解説

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ウィキペディア
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ウィキペディアウィキペディア

O-GlcNAc

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/02/27 14:20 UTC 版)

O-GlcNAc（O-結合型GlcNAc、O-結合型 N-アセチルグルコサミン）は、核や細胞質のタンパク質のセリン・スレオニン残基にみられる可逆的な翻訳後修飾である。この修飾は、セリンまたはスレオニン側鎖のヒドロキシル基とN-アセチルグルコサミン（GlcNAc）の間のβ-グリコシド結合によって特徴づけられる。O-GlcNAcは、(i) 伸長してより複雑な多糖構造を形成することがない、(ii) 膜タンパク質や分泌タンパク質ではなく核や細胞質のタンパク質に主に存在する、(iii) 高度に動的な修飾であり、迅速なターンオーバーが生じる、という点で他のグリコシル化修飾とは異なっている。O-GlcNAc修飾は、後生動物の間で保存されている[1]。


出典
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「O-GlcNAc」の関連用語

1
O-N-アセチルグルコサミン
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2
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O-GlcNAcのお隣キーワード

O-GlcNAc

O-GlcNAcアーゼ

O-GlcNAc転移酵素

OFR

OFR48

OFS

OG

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