HIF1Aとは？わかりやすく解説

HIF1A
PDBに登録されている構造
PDB	オルソログ検索: PDBe RCSB
PDBのIDコード一覧
	1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J
識別子
記号	HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit
外部ID	MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A
遺伝子の位置 (ヒト)
染色体	14番染色体 (ヒト)
終点	61,748,259 bp
遺伝子の位置 (マウス)
染色体	12番染色体 (マウス)
終点	73,947,530 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• protein dimerization activity; • transcription factor activity, sequence-specific DNA binding; • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; • histone deacetylase binding; • transcription factor activity, RNA polymerase II transcription factor binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • 転写因子結合; • enzyme binding; • 血漿タンパク結合; • histone acetyltransferase binding; • protein kinase binding; • Hsp90 protein binding; • sequence-specific DNA binding; • DNA binding; • transcription factor activity, transcription factor binding; • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; • 核内受容体結合; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • ubiquitin protein ligase binding; • protein heterodimerization activity; • E-box binding; • p53 binding; • protein domain specific binding;
細胞の構成要素	• 細胞質; • 細胞質基質; • 細胞核; • nuclear speck; • motile cilium; • transcription factor complex; • RNA polymerase II transcription factor complex; • axon cytoplasm; • 核質; • nuclear body; • タンパク質複合体;
生物学的プロセス	• negative regulation of neuron apoptotic process; • B-1 B cell homeostasis; • regulation of transforming growth factor beta2 production; • muscle cell cellular homeostasis; • outflow tract morphogenesis; • negative regulation of ossification; • heart looping; • negative regulation of TOR signaling; • blood vessel development; • hemoglobin biosynthetic process; • 血管新生; • positive regulation of chemokine-mediated signaling pathway; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • positive regulation of hormone biosynthetic process; • negative regulation of mesenchymal cell apoptotic process; • regulation of aerobic respiration; • positive regulation of neuroblast proliferation; • dopaminergic neuron differentiation; • lactate metabolic process; • regulation of transcription, DNA-templated; • blood vessel morphogenesis; • positive regulation of erythrocyte differentiation; • glucose homeostasis; • vascular endothelial growth factor production; • regulation of thymocyte apoptotic process; • positive regulation of epithelial cell migration; • negative regulation of thymocyte apoptotic process; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • axonal transport of mitochondrion; • positive regulation of macroautophagy; • cartilage development; • positive regulation of nitric-oxide synthase activity; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • 授乳; • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; • positive regulation of pri-miRNA transcription from RNA polymerase II promoter; • digestive tract morphogenesis; • 細胞分化; • neural fold elevation formation; • positive regulation of autophagy; • retina vasculature development in camera-type eye; • positive regulation of receptor biosynthetic process; • collagen metabolic process; • embryonic placenta development; • negative regulation of apoptotic process; • positive regulation of angiogenesis; • regulation of glycolytic process; • epithelial to mesenchymal transition; • cerebral cortex development; • 遺伝子発現調節; • positive regulation of chemokine production; • intestinal epithelial cell maturation; • regulation of catalytic activity; • positive regulation of autophagy of mitochondrion; • cardiac ventricle morphogenesis; • response to muscle activity; • epithelial cell differentiation involved in mammary gland alveolus development; • visual learning; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • negative regulation of bone mineralization; • negative regulation of growth; • response to hypoxia; • positive regulation of endothelial cell proliferation; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • iris morphogenesis; • mRNA transcription from RNA polymerase II promoter; • hypoxia-inducible factor-1alpha signaling pathway; • vasculature development; • regulation of cell proliferation; • neural crest cell migration; • embryonic hemopoiesis; • connective tissue replacement involved in inflammatory response wound healing; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • negative regulation of reactive oxygen species metabolic process; • positive regulation of vascular endothelial growth factor production; • elastin metabolic process; • positive regulation of glycolytic process; • oxygen homeostasis; • シグナル伝達; • positive regulation of transcription from RNA polymerase II promoter; • cellular iron ion homeostasis; • camera-type eye morphogenesis; • cellular response to hypoxia; • cellular response to interleukin-1; • transcription from RNA polymerase II promoter; • protein deubiquitination; • positive regulation of gene expression; • protein ubiquitination; • post-translational protein modification; • response to iron ion;
	出典:Amigo / QuickGO
オルソログ
	3091
	15251
	ENSG00000100644
	ENSMUSG00000021109
	Q16665,D0VY79,A8MYV6
	Q61221
	NM_181054; NM_001243084; NM_001530
	NM_010431; NM_001313919; NM_001313920
	NP_001230013; NP_001521; NP_851397; NP_001521.1
	NP_001300848; NP_001300849; NP_034561
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

HIF1Aはヘテロ二量体として構成される低酸素誘導因子HIF-1のうちHIF-1αサブユニットをコードしている遺伝子。^[5]^[6]^[7]

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100644 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021109 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ “Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q”. Genomics 34 (3): 437–9. (June 1996). doi:10.1006/geno.1996.0311. PMID 8786149.
^ “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. J. Biol. Chem. 272 (13): 8581–93. (March 1997). doi:10.1074/jbc.272.13.8581. PMID 9079689.
^ “Entrez Gene: HIF1A hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)”. 2017年10月10日閲覧。

参考文献

“HIF-1 and human disease: one highly involved factor”. Genes Dev. 14 (16): 1983–91. (2000). PMID 10950862.
“Signal transduction to hypoxia-inducible factor 1”. Biochem. Pharmacol. 64 (5–6): 993–8. (2002). doi:10.1016/S0006-2952(02)01168-1. PMID 12213597.
“Quiescent hypervascularity mediated by gain of HIF-1 alpha function”. Cold Spring Harb. Symp. Quant. Biol. 67: 133–42. (2002). doi:10.1101/sqb.2002.67.133. PMID 12858534.
“Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors”. Nat. Rev. Immunol. 5 (9): 712–21. (2005). doi:10.1038/nri1685. PMID 16110315.
“Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes”. Histol. Histopathol. 20 (4): 1327–38. (2005). PMID 16136514.
“Hypoxia and HIF-1 alpha in chondrogenesis”. Semin. Cell Dev. Biol. 16 (4–5): 539–46. (2006). doi:10.1016/j.semcdb.2005.03.003. PMID 16144691.
“Hypoxia-inducible factors in the kidney”. Am. J. Physiol. Renal Physiol. 291 (2): F271-81. (2006). doi:10.1152/ajprenal.00071.2006. PMID 16554418.
“Effects of histone deacetylase inhibitors on HIF-1”. Cell Cycle 5 (21): 2430–5. (2006). doi:10.4161/cc.5.21.3409. PMID 17102633.