ポリアデニル化とは？ わかりやすく解説

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ポリアデニル化

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/03/01 23:04 UTC 版)

ポリアデニル化（ポリアデニルか、英語: Polyadenylation）はRNAにポリA鎖（poly-A tail）を付加することである。ポリA鎖は多数のAMPから構成されており、RNAをアデニン塩基で伸長することに相当する。真核生物では、ポリアデニル化は翻訳可能な成熟mRNAを生産するために不可欠であり、広い意味では遺伝子発現過程の一部であるといえる。


出典
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[続きの解説]

「ポリアデニル化」の続きの解説一覧

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ポリアデニル化

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2020/12/27 02:09 UTC 版)

「RNA結合タンパク質」の記事における「ポリアデニル化」の解説

ポリアデニル化は、RNA転写産物の3' UTRのAAUAAA配列の約20塩基下流にアデニル酸残基からなる「テール」を付加する反応である。mRNAのポリアデニル化は、核輸送、翻訳効率、安定性に強い影響を与える。ポリアデニル化の過程やポリアデニル化による影響は、RNA結合タンパク質の特異的結合に依存している。わずかな例外を除いて、すべての真核生物のRNAはプロセシングを受けて約200ヌクレオチドからなる3'ポリ(A)テールが付加される。この過程に必要なタンパク質の1つがCPSF（英語版）である。CPSFは3'末尾のAAUAAA配列に結合し、ポリ(A)結合タンパク質と呼ばれる他のタンパク質とともに、ポリ(A)ポリメラーゼ（英語版）をリクルートし、その活性を促進する。ポリ(A)ポリメラーゼはそれ自体では不活性状態であり、適切に機能するためにはこれら他のタンパク質の結合が必要である。

※この「ポリアデニル化」の解説は、「RNA結合タンパク質」の解説の一部です。
「ポリアデニル化」を含む「RNA結合タンパク質」の記事については、「RNA結合タンパク質」の概要を参照ください。

ウィキペディア小見出し辞書の「ポリアデニル化」の項目はプログラムで機械的に意味や本文を生成しているため、不適切な項目が含まれていることもあります。ご了承くださいませ。 お問い合わせ。

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All text is available under the terms of the GNU Free Documentation License.
この記事は、ウィキペディアのポリアデニル化 (改訂履歴)の記事を複製、再配布したものにあたり、GNU Free Documentation Licenseというライセンスの下で提供されています。 Weblio辞書に掲載されているウィキペディアの記事も、全てGNU Free Documentation Licenseの元に提供されております。
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Text is available under GNU Free Documentation License (GFDL).
Weblio辞書に掲載されている「ウィキペディア小見出し辞書」の記事は、WikipediaのRNA結合タンパク質 (改訂履歴)の記事を複製、再配布したものにあたり、GNU Free Documentation Licenseというライセンスの下で提供されています。

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