Xist
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/02/09 23:23 UTC 版)
Xist（X-inactive specific transcript）は、哺乳類のX染色体にコードされているノンコーディングRNAで、X染色体不活性化過程の主要なエフェクターとして機能する[5]。他の2つのRNAコード遺伝子（Jpx、Ftx）、2つのタンパク質コード遺伝子（Tsx、Cnbp2）とともに [6]、Xic（X染色体不活性化中心）の構成要素[7] となっている。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000229807 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000086503 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c “Entrez Gene: XIST X (inactive)-specific transcript”. 2007年12月25日閲覧。
- ^ “Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine”. Genome Research 12 (6): 894–908. (June 2002). doi:10.1101/gr.152902. PMC 1383731. PMID 12045143.
- ^ “Silencing of the mammalian X chromosome”. Annual Review of Genomics and Human Genetics 6: 69–92. (2005). doi:10.1146/annurev.genom.6.080604.162350. PMID 16124854.
- ^ a b c “The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus”. Cell 71 (3): 527–42. (October 1992). doi:10.1016/0092-8674(92)90520-M. PMID 1423611.
- ^ “The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene”. Science 312 (5780): 1653–5. (June 2006). Bibcode: 2006Sci...312.1653D. doi:10.1126/science.1126316. PMID 16778056.
- ^ “Xist and the order of silencing” (Review Article). EMBO Reports 8 (1): 34–9. (January 2007). doi:10.1038/sj.embor.7400871. PMC 1796754. PMID 17203100.
- ^ “Requirement for Xist in X chromosome inactivation”. Nature 379 (6561): 131–7. (1996). Bibcode: 1996Natur.379..131P. doi:10.1038/379131a0. PMID 8538762.
- ^ C J Brown, A Ballabio, J L Rupert, R G Lafreniere, M Grompe, R Tonlorenzi , H F Willard (Jan 1991). “A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome”. Nature 349 (6304): 38–44. Bibcode: 1991Natur.349...38B. doi:10.1038/349038a0. PMID 1985261.
- ^ “Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control”. Nature Reviews Molecular Cell Biology 12 (12): 815–26. (2011). doi:10.1038/nrm3231. PMID 22108600.
- ^ a b “PNA interference mapping demonstrates functional domains in the noncoding RNA Xist”. Proceedings of the National Academy of Sciences of the United States of America 98 (16): 9215–20. (July 2001). Bibcode: 2001PNAS...98.9215B. doi:10.1073/pnas.161173098. PMC 55400. PMID 11481485.
- ^ “Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation”. Nature 460 (7255): 647–51. (July 2009). Bibcode: 2009Natur.460..647K. doi:10.1038/nature08161. PMC 2754729. PMID 19571810.
- ^ a b c d “2-D structure of the A region of Xist RNA and its implication for PRC2 association”. PLOS Biology 8 (1): e1000276. (January 2010). doi:10.1371/journal.pbio.1000276. PMC 2796953. PMID 20052282.
- ^ G Borsani, R Tonlorenzi, M C Simmler, L Dandolo, D Arnaud, V Capra, M Grompe, A Pizzuti, D Muzny, C Lawrence, H F Willard, P Avner, A Ballabio (May 1991). “Characterization of a murine gene expressed from the inactive X chromosome”. Nature 351 (6324): 325–9. Bibcode: 1991Natur.351..325B. doi:10.1038/351325a0. PMID 2034278.
- ^ N Brockdorff, A Ashworth, G F Kay, P Cooper, S Smith, V M McCabe, D P Norris, G D Penny, D Patel, S Rastan (May 1991). “Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome”. Nature 351 (6324): 329–31. Bibcode: 1991Natur.351..329B. doi:10.1038/351329a0. PMID 2034279.
- ^ “The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus”. Cell 71 (3): 515–26. (1992). doi:10.1016/0092-8674(92)90519-I. PMID 1423610.
- ^ a b “Tsix, a gene antisense to Xist at the X-inactivation centre”. Nature Genetics 21 (4): 400–4. (April 1999). doi:10.1038/7734. PMID 10192391.
- ^ Fang, Rui; Moss, Walter N.; Rutenberg-Schoenberg, Michael; Simon, Matthew D. (2015-12). “Probing Xist RNA Structure in Cells Using Targeted Structure-Seq”. PLoS genetics 11 (12): e1005668. doi:10.1371/journal.pgen.1005668. ISSN 1553-7404. PMC 4672913. PMID 26646615.
- ^ “Xist has properties of the X-chromosome inactivation centre”. Nature 386 (6622): 272–5. (March 1997). Bibcode: 1997Natur.386..272H. doi:10.1038/386272a0. PMID 9069284.
- ^ “Tsix, a gene antisense to Xist at the X-inactivation centre”. Nature Genetics 21 (4): 400–4. (April 1999). doi:10.1038/7734. PMID 10192391.
- ^ a b “Xist gene regulation at the onset of X inactivation”. Current Opinion in Genetics & Development 19 (2): 122–6. (April 2009). doi:10.1016/j.gde.2009.03.003. PMID 19345091.
- ^ “Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a”. Epigenetics & Chromatin 1 (1): 2. (October 2008). doi:10.1186/1756-8935-1-2. PMC 257704. PMID 19014663.
- ^ “Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation”. Genes & Development 19 (12): 1474–84. (June 2005). doi:10.1101/gad.341105. PMC 1151664. PMID 15964997.
- ^ “Intersection of the RNA interference and X-inactivation pathways”. Science 320 (5881): 1336–41. (June 2008). Bibcode: 2008Sci...320.1336O. doi:10.1126/science.1157676. PMC 2584363. PMID 18535243.
- ^ “Molecular coupling of Xist regulation and pluripotency”. Science 321 (5896): 1693–5. (September 2008). Bibcode: 2008Sci...321.1693N. doi:10.1126/science.1160952. PMID 18802003.
- ^ “Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome”. Science 322 (5902): 750–6. (October 2008). Bibcode: 2008Sci...322..750Z. doi:10.1126/science.1163045. PMC 2748911. PMID 18974356.
- ^ “Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation”. Developmental Cell 7 (5): 663–76. (2004). doi:10.1016/j.devcel.2004.10.005. PMID 15525528.
- ^ a b “Dosage compensation of the active X chromosome in mammals”. Nature Genetics 38 (1): 47–53. (January 2006). doi:10.1038/ng1705. PMID 16341221.
- ^ “Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation”. The Journal of Cell Biology 153 (4): 773–84. (May 2001). doi:10.1083/jcb.153.4.773. PMC 2192370. PMID 11352938.
- ^ “Dosage compensation of the X chromosome and Turner syndrome=International-Congress-series”. International Congress Series 1298: 3–8. (2006). doi:10.1016/j.ics.2006.06.012.
- ^ “Reactivation of the paternal X chromosome in early mouse embryos”. Science 303 (5658): 666–9. (January 2004). Bibcode: 2004Sci...303..666M. doi:10.1126/science.1092674. PMID 14752160.
- ^ “Xist expression and macroH2A1.2 localisation in mouse primordial and pluripotent embryonic germ cells”. Differentiation; Research in Biological Diversity 69 (4–5): 216–25. (January 2002). doi:10.1046/j.1432-0436.2002.690415.x. PMID 11841480.
- ^ “Association of BRCA1 with the inactive X chromosome and XIST RNA”. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 359 (1441): 123–8. (January 2004). doi:10.1098/rstb.2003.1371. PMC 1693294. PMID 15065664.
- ^ “BRCA1 supports XIST RNA concentration on the inactive X chromosome”. Cell 111 (3): 393–405. (November 2002). doi:10.1016/S0092-8674(02)01052-8. PMID 12419249.
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