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インターロイキン10

英訳・(英)同義/類義語:interleukin 10, IL-10

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Il-10 (航空機)

(Il10 から転送)

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/07/08 07:18 UTC 版)

Il-10 / Ил-10
B-33


注釈

  1. ^ 冬戦争時に空軍内で発足した空軍防空部隊が独立したもの。後身は国土防空軍。
  2. ^ このうちIl-10は4966機、B-33は1200機。

出典

  1. ^ ミチュレック(Michulec)1999, p. 24.


「Il-10 (航空機)」の続きの解説一覧

インターロイキン-10

(Il10 から転送)

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/05/24 13:51 UTC 版)

インターロイキン-10: interleukin-10、略称: IL-10)またはCSIF(cytokine synthesis inhibitory factor)は、ヒトではIL10遺伝子にコードされるサイトカインである[5]。IL-10シグナルは、2分子のαサブユニット英語版と2分子のβサブユニット英語版からなるIL-10受容体英語版を介して伝達される[6]。IL-10の結合によってαサブユニットとβサブユニットの細胞質テールが、それぞれJAK1英語版TYK2英語版によってリン酸化され、STAT3シグナルが誘導される[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136634 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016529 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
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  25. ^ a b “Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10”. Journal of Immunology 160 (12): 5936–44. (June 1998). doi:10.4049/jimmunol.160.12.5936. PMID 9637507. http://www.jimmunol.org/content/160/12/5936.long. 
  26. ^ “Cellular mechanisms that cause suppressed gamma interferon secretion in endotoxin-tolerant mice”. Infection and Immunity 69 (9): 5249–63. (September 2001). doi:10.1128/iai.69.9.5249-5263.2001. PMC 98633. PMID 11500393. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC98633/. 
  27. ^ “Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism”. The Journal of Experimental Medicine 184 (2): 579–84. (August 1996). doi:10.1084/jem.184.2.579. PMC 2192723. PMID 8760811. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192723/. 
  28. ^ “Interleukin-10 gene transfer activates interferon-gamma and the interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors”. International Journal of Cancer 80 (4): 624–9. (February 1999). doi:10.1002/(sici)1097-0215(19990209)80:4<624::aid-ijc23>3.0.co;2-9. PMID 9935167. 
  29. ^ “Essential role of nitric oxide and interferon-gamma for tumor immunotherapy with interleukin-10”. Journal of Immunotherapy 23 (2): 208–14. (2000-04-01). doi:10.1097/00002371-200003000-00005. PMID 10746547. 
  30. ^ “Interleukin-10 promotes the maintenance of antitumor CD8(+) T-cell effector function in situ”. Blood 98 (7): 2143–51. (October 2001). doi:10.1182/blood.v98.7.2143. PMID 11568001. 
  31. ^ “Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice”. Journal of Immunology 157 (1): 231–8. (July 1996). doi:10.4049/jimmunol.157.1.231. PMID 8683120. 
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  33. ^ a b “IL-10 elicits IFNγ-dependent tumor immune surveillance”. Cancer Cell 20 (6): 781–96. (December 2011). doi:10.1016/j.ccr.2011.11.003. PMID 22172723. 
  34. ^ “The Potentiation of IFN-γ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells”. Journal of Interferon & Cytokine Research 35 (12): 948–55. (December 2015). doi:10.1089/jir.2014.0221. PMID 26309093. 
  35. ^ “Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B”. Nature Immunology 8 (10): 1095–104. (October 2007). doi:10.1038/ni1503. PMID 17767162. 
  36. ^ “Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age”. Experimental Gerontology 48 (2): 128–35. (February 2013). doi:10.1016/j.exger.2012.11.001. PMC 3744178. PMID 23159957. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744178/. 
  37. ^ “Physical activity and plasma interleukin-6 in humans--effect of intensity of exercise”. European Journal of Applied Physiology 83 (6): 512–5. (December 2000). doi:10.1007/s004210000312. PMID 11192058. 
  38. ^ “Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans”. The Journal of Physiology 515 (1): 287–91. (February 1999). doi:10.1111/j.1469-7793.1999.287ad.x. PMC 2269132. PMID 9925898. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269132/. 
  39. ^ “Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment”. Scandinavian Journal of Immunology 49 (5): 554–61. (May 1999). doi:10.1046/j.1365-3083.1999.00546.x. PMID 10320650. 
  40. ^ “Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism”. European Journal of Immunology 38 (4): 1106–17. (April 2008). doi:10.1002/eji.200737821. PMID 18383040. 
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  42. ^ “Interleukin 10 decreases MICA expression on melanoma cell surface”. Immunology and Cell Biology 89 (3): 447–57. (March 2011). doi:10.1038/icb.2010.100. hdl:10533/132162. PMID 20714339. 
  43. ^ “Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients”. Cytokine 138: 155351. (February 2021). doi:10.1016/j.cyto.2020.155351. ISSN 1043-4666. PMID 33127257. https://www.sciencedirect.com/science/article/pii/S1043466620303677. 
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  45. ^ “Interleukin-10 deficiency aggravates traumatic brain injury in male but not female mice”. Exp Neurol 355: 114125. (September 2022). doi:10.1016/j.expneurol.2022.114125. PMID 35644427. 
  46. ^ Entrez Gene: IL10 interleukin 10”. 2024年5月19日閲覧。
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  52. ^ “Interleukin 10 treatment of psoriasis: clinical results of a phase 2 trial”. Archives of Dermatology 135 (2): 187–92. (February 1999). doi:10.1001/archderm.135.2.187. PMID 10052405. 
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  61. ^ “Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1”. Acta Crystallographica Section D 57 (Pt 12): 1908–11. (December 2001). Bibcode2001AcCrD..57.1908J. doi:10.1107/S0907444901016249. PMID 11717514. 
  62. ^ “Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization”. European Journal of Biochemistry 262 (1): 134–41. (May 1999). doi:10.1046/j.1432-1327.1999.00363.x. PMID 10231374. 


「インターロイキン-10」の続きの解説一覧


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