アロマターゼ
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/06/05 04:59 UTC 版)
アロマターゼ(Aromatase, EC 1.14.14.14)は、エストロゲンシンテターゼ(estrogen synthetase)またはエストロゲンシンターゼと(estrogen synthase)も呼ばれ、エストロゲンの生合成に関与する酵素である。シトクロムP450スーパーファミリーの一つCYP19A1は、ステロイドの産生に関する様々な反応を触媒するモノオキシゲナーゼである。特に、アロマターゼはアンドロゲンを芳香化してエストロゲンに変換する反応に関与している。アロマターゼは、性腺(顆粒膜細胞)、脳、脂肪組織、胎盤、血管、皮膚、骨などの多くの体組織のほか、子宮内膜症や子宮筋腫、乳癌、および子宮体癌の病巣部に見られる[要出典]。
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- 1 アロマターゼとは
- 2 アロマターゼの概要
- 3 機能
- 4 活性
- 5 アロマターゼの阻害
- アロマターゼのページへのリンク