グリコシルトランスフェラーゼ
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/11/11 07:34 UTC 版)
グリコシルトランスフェラーゼまたは糖転移酵素（とうてんいこうそ、英: glycosyltransferase）は、グリコシド結合を形成する酵素（EC 2.4）である。活性化された糖ヌクレオチド（糖供与体と呼ばれる）から糖部分を求核的な糖受容体へ転移する過程を触媒する。求核剤は酸素、炭素、窒素、硫黄系の場合がある[1]。
- ^ Williams, GJ; Thorson, JS (2009). Natural product glycosyltransferases: properties and applications.. Advances in Enzymology - and Related Areas of Molecular Biology. 76. 55–119. doi:10.1002/9780470392881.ch2. ISBN 9780470392881. PMID 18990828
- ^ Essentials of Glycobiology (2nd ed.). Plainview, N.Y: Cold Spring Harbor Laboratory Press. (2008). ISBN 978-0-87969-770-9
- ^ Transferases in Membranome database.
- ^ “Geometric Attributes of Retaining Glycosyltransferase Enzymes Favor an Orthogonal Mechanism”. PLoS ONE 8 (8): e71077. (August 2013). doi:10.1371/journal.pone.0071077. PMC 3731257. PMID 23936487.
- ^ Zhang, C; Griffith, BR; Fu, Q; Albermann, C; Fu, X; Lee, IK; Li, L; Thorson, JS (1 September 2006). “Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions.”. Science 313 (5791): 1291–4. doi:10.1126/science.1130028. PMID 16946071.
- ^ Zhang, C; Albermann, C; Fu, X; Thorson, JS (27 December 2006). “The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.”. Journal of the American Chemical Society 128 (51): 16420–1. doi:10.1021/ja065950k. PMID 17177349.
- ^ Zhang, C; Fu, Q; Albermann, C; Li, L; Thorson, JS (5 March 2007). “The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification.”. ChemBioChem: A European Journal of Chemical Biology 8 (4): 385–90. doi:10.1002/cbic.200600509. PMID 17262863.
- ^ Zhang, C; Moretti, R; Jiang, J; Thorson, JS (13 October 2008). “The in vitro characterization of polyene glycosyltransferases AmphDI and NysDI.”. ChemBioChem: A European Journal of Chemical Biology 9 (15): 2506–14. doi:10.1002/cbic.200800349. PMC 2947747. PMID 18798210.
- ^ Gantt, RW; Peltier-Pain, P; Cournoyer, WJ; Thorson, JS (21 August 2011). “Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions.”. Nature Chemical Biology 7 (10): 685–91. doi:10.1038/nchembio.638. PMC 3177962. PMID 21857660.
- ^ “Glycosyltransferases - CAZypedia” (英語). cazypedia.org. 2020年9月4日閲覧。
- ^ “CAZy - GT”. www.cazy.org. 2020年9月4日閲覧。
- ^ Singh, S; Phillips GN, Jr; Thorson, JS (October 2012). “The structural biology of enzymes involved in natural product glycosylation”. Natural Product Reports 29 (10): 1201–37. doi:10.1039/c2np20039b. PMC 3627186. PMID 22688446.
- ^ Chang, A; Singh, S; Phillips GN, Jr; Thorson, JS (December 2011). “Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation”. Current Opinion in Biotechnology 22 (6): 800–8. doi:10.1016/j.copbio.2011.04.013. PMC 3163058. PMID 21592771.
- ^ “SCOPe: Structural Classification of Proteins — extended. Release 2.07 (updated 2020-07-16, stable release March 2018)” (英語). scop.berkeley.edu. 2020年9月4日閲覧。
- ^ “Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis”. Science 315 (5817): 1402–5. (March 2007). doi:10.1126/science.1136611. PMID 17347437.
- ^ Kocev, A; Melamed, J; Wang, S; Kong, X; Vlahakis, JZ; Xu, Y; Szarek, WA; Brockhausen, I (June 2020). "Inhibition of bacterial growth and galactosyltransferase activity of WbwC by α, ω-bis(3-alkyl-1H-imidazolium)alkane salts: Effect of varying carbon content". Bioorganic and Medicinal Chemistry. 28 (11): 115494. doi:10.1016/j.bmc.2020.115494. PMID 32312486.
- ^ Gantt, RW; Peltier-Pain, P; Thorson, JS (October 2011). “Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.”. Natural Product Reports 28 (11): 1811–53. doi:10.1039/c1np00045d. PMID 21901218.
[続きの解説]
「グリコシルトランスフェラーゼ」の続きの解説一覧
- 1 グリコシルトランスフェラーゼとは
- 2 グリコシルトランスフェラーゼの概要
- 3 配列による分類
- 4 利用
- グリコシルトランスフェラーゼのページへのリンク
