長期増強とは? わかりやすく解説

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長期増強

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/11/29 09:50 UTC 版)

神経科学の分野において、長期増強(ちょうきぞうきょう、: Long-term potentiation、略称: LTP)は、神経細胞を同時刺激することにより2つの神経細胞間の信号伝達が持続的に向上する現象である[2]。神経細胞はシナプス結合を介して信号伝達しており、記憶はこのシナプスに貯えられていると信じられているので[3]、長期増強は学習記憶の根底にある主要な細胞学的機構の1つであると広く考えられている[2]


  1. ^ Bear, Mark F.; Michael A. Paradiso (2006) (Digitised online by google books). Neuroscience: Exploring the Brain. Lippincott Williams & Wilkins. p. 718. ISBN 0781760038, 9780781760034 
  2. ^ a b c d Cooke SF, Bliss TV (2006). “Plasticity in the human central nervous system”. Brain 129 (Pt 7): 1659-73. doi:10.1093/brain/awl082. PMID 16672292. 
  3. ^ Boron, Walter F.. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3 
  4. ^ a b c d e f g h i j k l Malenka R, Bear M (2004). “LTP and LTD: an embarrassment of riches”. Neuron 44 (1): 5-21. doi:10.1016/j.neuron.2004.09.012. PMID 15450156. 
  5. ^ Williams RW, Herrup K (1988). “The control of neuron number”. Annu. Rev. Neurosci. 11: 423-53. doi:10.1146/annurev.ne.11.030188.002231. PMID 3284447. http://www.nervenet.org/papers/NUMBER_REV_1988.html. 
  6. ^ a b Ramon y Cajal, Santiago (1894). “The Croonian Lecture: La Fine Structure des Centres Nerveux”. Proceedings of the Royal Society of London 55: 444-468. doi:10.1098/rspl.1894.0063. 
  7. ^ a b Terje Lomo (2003). “The discovery of long-term potentiation”. Philos Trans R Soc Lond B Biol Sci 358 (1432): 617-20. doi:10.1098/rstb.2002.1226. PMID 12740104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12740104. 
  8. ^ a b Bliss T, Lomo T (1973). “Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path”. J Physiol 232 (2): 331-56. PMID 4727084. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1350458&blobtype=pdf. 
  9. ^ a b Bliss T, Gardner-Medwin A (1973). “Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path”. J. Physiol. (Lond.) 232 (2): 357-74. PMID 4727085. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1350459&blobtype=pdf. 
  10. ^ 元々のブリスとレモの論文でも "long term potentiation" という用語は使われているものの、ダグラスとゴダールの論文までは公式的な呼称ではなかった。
  11. ^ Douglas R, Goddard G (1975). “Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus”. Brain Res. 86 (2): 205-15. doi:10.1016/0006-8993(75)90697-6. PMID 163667. 
  12. ^ Andersen P (2003). “A prelude to long-term potentiation”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 358 (1432): 613-5. doi:10.1098/rstb.2002.1232. PMID 12740103. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1693144&blobtype=pdf. 
  13. ^ Clugnet, MC; LeDoux JE (1 Aug 1990). “Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body.” (PDF). J Neurosci 10 (8): 2818-24. PMID 2388089. http://www.jneurosci.org/cgi/reprint/10/8/2818. 
  14. ^ Yasuda H, Barth A, Stellwagen D, Malenka R (2003). “A developmental switch in the signaling cascades for LTP induction”. Nat Neurosci 6 (1): 15-6. doi:10.1038/nn985. PMID 12469130. 
  15. ^ Harris E, Cotman C (1986). “Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl D-aspartate antagonists”. Neurosci Lett 70 (1): 132-7. doi:10.1016/0304-3940(86)90451-9. PMID 3022192. 
  16. ^ McNaughton BL (April 2003). “Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history”. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 358 (1432): 629-34. doi:10.1098/rstb.2002.1231. PMC 1693161. PMID 12740107. http://journals.royalsociety.org/openurl.asp?genre=article&issn=0962-8436&volume=358&issue=1432&spage=629. 
  17. ^ a b c d e f g h i Sweatt J (1999). “Toward a molecular explanation for long-term potentiation”. Learn Mem 6 (5): 399-416. doi:10.1101/lm.6.5.399. PMID 10541462. http://www.learnmem.org/cgi/content/full/6/5/399. 
  18. ^ a b c d e f g h i j Lynch M (2004). “Long-term potentiation and memory”. Physiol Rev 84 (1): 87-136. doi:10.1152/physrev.00014.2003. PMID 14715912. http://physrev.physiology.org/cgi/content/full/84/1/87. 
  19. ^ Huang Y, Kandel E (1994). “Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization”. Learn Mem 1 (1): 74-82. PMID 10467587. 
  20. ^ Agranoff, Bernard W.; Siegel, George J. (1999). Basic neurochemistry: molecular, cellular, and medical aspects. Philadelphia: Lippincott-Raven. pp. 326. ISBN 0-397-51820-X. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=bnchm.section.1131 
  21. ^ Malinow R (2003). “AMPA receptor trafficking and long-term potentiation”. Philos Trans R Soc Lond B Biol Sci 358 (1432): 707-14. doi:10.1098/rstb.2002.1233. PMID 12740116. 
  22. ^ a b Emptage N, Reid C, Fine A, Bliss T (2003). “Optical quantal analysis reveals a presynaptic component of LTP at hippocampal Schaffer-associational synapses”. Neuron 38 (5): 797-804. doi:10.1016/S0896-6273(03)00325-8. PMID 12797963. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSS-4C5XN9K-G&_coverDate=06%2F05%2F2003&_alid=523934887&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=7054&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=15f6a55d9b53d2265077f3a74a8a495a. 
  23. ^ Frey U, Frey S, Schollmeier F, Krug M (1 Jan 1996). “Influence of actinomycin D, a RNA synthesis inhibitor, on long-term potentiation in rat hippocampal neurons in vivo and in vitro”. J Physiol 490 (Pt 3) (Pt 3): 703-11. PMID 8683469. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8683469. 
  24. ^ Frey U, Krug M, Reymann K, Matthies H (1988). “Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro”. Brain Res 452 (1-2): 57-65. doi:10.1016/0006-8993(88)90008-X. PMID 3401749. 
  25. ^ a b c d e f Kelleher R, Govindarajan A, Tonegawa S (2004). “Translational regulatory mechanisms in persistent forms of synaptic plasticity”. Neuron 44 (1): 59-73. doi:10.1016/j.neuron.2004.09.013. PMID 15450160. 
  26. ^ Kovacs KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (2007). “TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity.”. PNAS 104 (11): 4700-5. doi:10.1073/pnas.0607524104. PMID 17360587. 
  27. ^ a b c d Serrano P, Yao Y, Sacktor T (2005). “Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation”. J Neurosci 25 (8): 1979-84. doi:10.1523/JNEUROSCI.5132-04.2005. PMID 15728837. 
  28. ^ a b c Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton A, Sacktor T (2006). “Storage of spatial information by the maintenance mechanism of LTP”. Science 313 (5790): 1141-4. doi:10.1126/science.1128657. PMID 16931766. 
  29. ^ Kang H, Schuman E (1996). “A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity”. Science 273 (5280): 1402-6. doi:10.1126/science.273.5280.1402. PMID 8703078. 
  30. ^ Steward O, Worley P (2001). “A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites”. Proc Natl Acad Sci USA 98 (13): 7062-8. doi:10.1073/pnas.131146398. PMID 11416188. http://www.pnas.org/cgi/content/full/98/13/7062. 
  31. ^ Pavlidis P, Montgomery J, Madison D (2000). “Presynaptic protein kinase activity supports long-term potentiation at synapses between individual hippocampal neurons”. J Neurosci 20 (12): 4497-505. PMID 10844019. 
  32. ^ Zakharenko S, Patterson S, Dragatsis I, Zeitlin S, Siegelbaum S, Kandel E, Morozov A (2003). “Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses”. Neuron 39 (6): 975-90. doi:10.1016/S0896-6273(03)00543-9. PMID 12971897. 
  33. ^ Frey U, Morris R (1997). “Synaptic tagging and long-term potentiation”. Nature 385 (6616): 533-6. doi:10.1038/385533a0. PMID 9020359. 
  34. ^ Martin K, Casadio A, Zhu H, Yaping E, Rose J, Chen M, Bailey C, Kandel E (1997). “Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage”. Cell 91 (7): 927-38. doi:10.1016/S0092-8674(00)80484-5. PMID 9428516. 
  35. ^ Casadio A, Martin K, Giustetto M, Zhu H, Chen M, Bartsch D, Bailey C, Kandel E (1999). “A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis”. Cell 99 (2): 221-37. doi:10.1016/S0092-8674(00)81653-0. PMID 10535740. 
  36. ^ Segal M, Murphy D (1999). “CREB activation mediates plasticity in cultured hippocampal neurons”. Neural Plast 6 (3): 1-7. doi:10.1155/NP.1998.1. PMID 9920677. 
  37. ^ Straube T, Frey J (2003). “Involvement of beta-adrenergic receptors in protein synthesis-dependent late long-term potentiation (LTP) in the dentate gyrus of freely moving rats: the critical role of the LTP induction strength”. Neuroscience 119 (2): 473-9. doi:10.1016/S0306-4522(03)00151-9. PMID 12770561. 
  38. ^ Lu Y, Kandel E, Hawkins R (1999). “Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus”. J Neurosci 19 (23): 10250-61. PMID 10575022. 
  39. ^ Frey U, Matthies H, Reymann K, Matthies H (1991). “The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro”. Neurosci Lett 129 (1): 111-4. doi:10.1016/0304-3940(91)90732-9. PMID 1833673. 
  40. ^ Otmakhova N, Lisman J (1996). “D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses”. J Neurosci 16 (23): 7478-86. PMID 8922403. 
  41. ^ Morris RG, Anderson E, Lynch GS, Baudry M (1986). “Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5”. Nature 319 (6056): 774-6. doi:10.1038/319774a0. PMID 2869411. 
  42. ^ McHugh T, Blum K, Tsien J, Tonegawa S, Wilson M (1996). “Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice”. Cell 87 (7): 1339-49. doi:10.1016/S0092-8674(00)81828-0. PMID 8980239. 
  43. ^ Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ (1999). “Genetic enhancement of learning and memory in mice”. Nature 401: 63-69. doi:10.1038/43432. PMID 10485705. http://www.nature.com/nature/journal/v401/n6748/abs/401063a0.html. 
  44. ^ Tang Y, Wang H, Feng R, Kyin M, Tsien J (2001). “Differential effects of enrichment on learning and memory function in NR2B transgenic mice”. Neuropharmacology 41 (6): 779-90. doi:10.1016/S0028-3908(01)00122-8. PMID 11640933. 
  45. ^ Whitlock J, Heynen A, Shuler M, Bear M (2006). “Learning induces long-term potentiation in the hippocampus”. Science 313 (5790): 1093-7. doi:10.1126/science.1128134. PMID 16931756. 
  46. ^ Bliss T, Collingridge G, Laroche S (2006). “Neuroscience. ZAP and ZIP, a story to forget”. Science 313 (5790): 1058-9. doi:10.1126/science.1132538. PMID 16931746. 
  47. ^ a b Rowan MJ, Klyubin I, Cullen WK, Anwyl R (April 2003). “Synaptic plasticity in animal models of early Alzheimer's disease”. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 358 (1432): 821-8. doi:10.1098/rstb.2002.1240. PMC 1693153. PMID 12740129. http://journals.royalsociety.org/openurl.asp?genre=article&issn=0962-8436&volume=358&issue=1432&spage=821. 
  48. ^ Crary JF, Shao CY, Mirra SS, Hernandez AI, Sacktor TC (April 2006). “Atypical protein kinase C in neurodegenerative disease I: PKMzeta aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer disease”. Journal of neuropathology and experimental neurology 65 (4): 319-26. doi:10.1097/01.jnen.0000218442.07664.04. PMID 16691113. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00005072-200604000-00002. 
  49. ^ a b Kauer JA, Malenka RC (November 2007). “Synaptic plasticity and addiction”. Nature reviews. Neuroscience 8 (11): 844-58. doi:10.1038/nrn2234. PMID 17948030. 
  50. ^ Wolf ME (August 2003). “LTP may trigger addiction”. Molecular interventions 3 (5): 248-52. doi:10.1124/mi.3.5.248. PMID 14993438. http://molinterv.aspetjournals.org/cgi/pmidlookup?view=long&pmid=14993438. 


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