アルキルグリセロール
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2021/10/17 05:25 UTC 版)
アルキルグリセロール(=アルコキシグリセロール、Alkyl glycerol、略号:AKG)は、グリセリンとエーテル結合を持つ化合物であり、クミルアルコール,バチルアルコール,セラキルアルコールが主な成分であり、エーテル脂質(Ether lipid)とも言う。人体の肝臓・脾臓・骨髄・赤血球・血漿中に存在する。ヒトの母乳や牛乳などにも含まれるが、比較的サメの肝臓に多く含まれていることが知られている。なお、サメの持つアルキルグリセロールは、免疫刺激物質およびガンの強力な治療薬などとして用いられている。
- ^ Brohult A,Brohult J,Brohult S et al.
Reduced mortality in cancer patients after administration of alkoxygylycerols.
Acta Obs Gynecol Scand 1986;65:779-785 - ^ Alexander P,Connel T,Brohult A et al.
Reduction of radiation induced shortening of life-span by a diet augmented with alkoxygylycerols and essential fatty acids.
Gerontologia 1959;3:147 - ^ a b Brohult A. Alkoxygylycerols and their use in radiation.
Acta Radiol 1963;223(Suppl):7 - ^ Peifer JJ,Lundberg WO Ishio S et al.
Arch Biochem Biophys 1965;110:270 - ^ a b Carlson WE.
MSc thesis.Vancouver,Canada:University of British Columbia.1966 - ^ a b Berger FM.
The relationship between chemical structure and central depressant action of a-substituted ethers of glycerols.
J Pharmacol Exp Ther 1948;93:470 - ^ Bandi ZT,Mangold HK,Holmer G et al.
Substrate specificity of enzymes catalyzing interconversions of long-chain acids and alcohols in the rat.
FEPS 1 1971;12:217 - ^ a b c Scander OE. Some experimental studies on the erythropoietic effect of yellow bone marrow extracts and batyl alcohol.
Acta Med Scand 133: 1949;225:72 - ^ Emmerie A,Engel C,Klip W.
J Sci Food Agr 1952;3:264 - ^ Hugo WB,Stretton RJ.
The role of cellular lipid in the resistance of some Gram-positive bacteria to penicillins.
J Gen Microbiol 1966;42:133-138 - ^ a b Brohult A,Holmberg J.
Alkylglycerols in the treatment of leucopenia caused by irradiation.
Nature(London) 1954;174:1102 - ^ Linman JW.
Hemopoietic effects of batyl alcohol.
J Clin Invest 1958;37:913 - ^ Osmond DG,Roylance PJ,Webb AJ et al.
Acta Haematol 1963;29:180 - ^ Suki WN,Grollman A.
The effect of batyl alcohol and related alkylglycerols on hemopoiesis in the rat.
Tex Rep Biol Med 1960;18:662 - ^ Lorenze E,Congdon C,Uphoff D. Modification of acute irradiation injury in mice and guineapigs by bone marrow injections.
Radiology 1952;8:863 - ^ Arturson G,Lindhack M. Experiments on the effects of batyl alcohol on the number of erythrocytes and reticulocytes in white mice.
Acta Soc Med Upsal 1951;56:19 - ^ a b Brohult A,Brohult J,Brohult S et al.
Effect of alkylglycerols on the frequency of injuries following radiation therapy for carcinoma of the uterine cervix.
Acta Obs Gynecol Scand 1979;58:203-207 - ^ Adams DO,Hamilton TA.
The cell biology of macrophage activation.
Ann Rev Imunnol 1984;2:283-316 - ^ Hallgren B,Niclasson A,Stallberg G et al.
On the occurrence of 1-O-alkylglycerols and 1-O-(2-methoxy alkyl)glycerols in human colostrum,human milk,cow's milk sheepsmilk,human red bone marrow,red cells,blood plasma and a uterine carcinoma.
Acta Chem Scand 1974;B28:1029-1034 - ^ Wilson E,Olcott MC,Bell RM et al.
J Biol Chem 1986;261:12616-12623 - ^ Yamamoto N,St Clair DA,Homma S et al.
Activation of mouse macrophages by alkylglyxerols,inflammation products of cancerous tissues.
Cancer Res 1988;48:6044-6049 - ^ Oh SK,Jadhav LA.
Effects of dietary alkylglycerols in lactating rats on immune response in pups.
Pediat Res 1994;36:300-305 - ^ Brohult J,Personal communication
- 1 アルキルグリセロールとは
- 2 アルキルグリセロールの概要
- 3 免疫学的側面
- 4 論文・研究発表
- アルキルグリセロールのページへのリンク