ペチジン
メペリジン
メペリジン
ペチジン
(メペリジン から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/05/06 09:00 UTC 版)
ペチジン（英: Pethidine）、別名メペリジン（英: Meperidine）は、フェニルピペリジン系の合成オピオイド鎮痛薬の一つである[1][2][3][4][5][6]、1939年にドイツで抗コリン薬として合成され、その後鎮痛作用が発見された[7]。中枢に作用して鎮痛作用を示す。塩酸塩として経口、皮下注射、筋肉内注射、静脈内注射で用いられる。中等度または重度の疼痛に対する鎮痛薬あるいは麻酔前投与薬として使用される。日本での商品名は「オピスタン」（田辺三菱製薬）または「ペチジン塩酸塩」（武田薬品工業）。米国では多くの医師に使用されており、1975年の調査では60%の医師が急性疼痛に、22%の医師が重症慢性疼痛に処方した[8]。
- ^ “Demerol, Pethidine (meperidine) dosing, indications, interactions, adverse effects, and more”. Medscape Reference. WebMD. 2014年4月9日閲覧。
- ^ Shipton, E (March 2006). “Should New Zealand continue signing up to the Pethidine Protocol?” (PDF). The New Zealand Medical Journal 119 (1230): U1875. PMID 16532042. オリジナルの2014年4月8日時点におけるアーカイブ。.
- ^ a b c d Latta, KS; Ginsberg, B; Barkin, RL (January–February 2002). “Meperidine: a critical review.”. American Journal of Therapeutics 9 (1): 53–68. doi:10.1097/00045391-200201000-00010. PMID 11782820.
- ^ a b MacPherson, RD; Duguid, MD (2008). “Strategy to Eliminate Pethidine Use in Hospitals” (PDF). Journal of Pharmacy Practice and Research 38 (2): 88–89.
- ^ Mather, LE; Meffin, PJ (September–October 1978). “Clinical pharmacokinetics of pethidine.”. Clinical Pharmacokinetics 3 (5): 352–68. doi:10.2165/00003088-197803050-00002. PMID 359212.
- ^ a b Rossi, S, ed (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3
- ^ Michaelis, Martin; Schölkens, Bernward; Rudolphi, Karl (April 2007). “An anthology from Naunyn-Schmiedeberg's archives of pharmacology”. Naunyn-Schmiedeberg's Archives of Pharmacology (Springer Berlin) 375 (2): 81–84. doi:10.1007/s00210-007-0136-z. PMID 17310263.
- ^ Kaiko, Robert F.; Kathleen M. Foley; Patricia Y. Grabinski; George Heidrich; Ada G. Rogers; Charles E. Inturrisi; Marcus M. Reidenberg (February 1983). “Central Nervous System Excitatory Effects of Meperidine in Cancer Patients”. Annals of Neurology (Wiley Interscience) 13 (2): 180–185. doi:10.1002/ana.410130213. PMID 6187275.
- ^ a b c d e “オピスタン原末 添付文書” (2015年4月). 2016年4月5日閲覧。
- ^ a b c d e “ペチジン塩酸塩注射液35mg／ペチジン塩酸塩注射液50mg 添付文書” (2015年7月). 2016年11月6日閲覧。
- ^ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
- ^ “Parenteral opioids for labor pain relief: A systematic review - American Journal of Obstetrics & Gynecology”. www.ajog.org. 2015年7月11日閲覧。
- ^ “Narcotics for Pain During Labor: Types & Side Effects”. 2015年6月20日閲覧。
- ^ “WHO en:Template:! Parenteral opioids for maternal pain relief in labour”. apps.who.int. 2015年6月20日閲覧。
- ^ “Pain relief in labour - Pregnancy and baby guide - NHS Choices”. www.nhs.uk. 2015年6月20日閲覧。
- ^ Blueprints - Family Medicine (3rd edition)
- ^ Baselt, R. (2008). Disposition of Toxic Drugs and Chemicals in Man (8 ed.). Foster City, CA: Biomedical Publications. pp. 911-914.
- ^ Package insert for meperidine hydrochloride, Boehringer Ingelheim, Ridgefield, CT, 2005.
- ^ Brody, Jane (2007年2月27日). “A Mix of Medicines That Can Be Lethal”. New York Times 2009年2月13日閲覧. "The death of Libby Zion, an 18-year-old college student, in a New York hospital on March 5, 1984, led to a highly publicized court battle and created a cause célèbre over the lack of supervision of inexperienced and overworked young doctors. But only much later did experts zero in on the preventable disorder that apparently led to Ms. Zion’s death: a form of drug poisoning called serotonin syndrome."
- ^ Bronwen Bryant and Kathleen Knights (2010). Pharmacology for Health Professionals, 3rd Edition. Chatswood: Mosby Australia. ISBN 978-0-7295-3929-6
- ^ Koczmara, C; Perri, D; Hyland, S; Rousseaux, L (2005). “Meperidine (Demerol) safety issues”. Official Journal of the Canadian Association of Critical Care Nurses 16 (1): 8–12. ISSN 1201-2580 2014年1月11日閲覧。.
- ^ Laurence, Brunton (2010). Goodman & Gilman's pharmacological basis of therapeutics (12th ed.). McGraw-Hill. p. 549. ISBN 0071624422
- ^ http://www.fass.se/LIF/produktfakta/artikel_produkt.jsp?NplID=19741206000040&DocTypeID=3&UserTypeID=0
- ^ Wagner, Larry E., II; Michael Eaton; Salas S. Sabnis; Kevin J. Gingrich (November 1999). “Meperidine and Lidocaine Block of Recombinant Voltage-Dependent Na+ Channels: Evidence that Meperidine is a Local Anesthetic”. Anesthesiology (Lippincott Williams & Wilkins) 91 (5): 1481–1490. doi:10.1097/00000542-199911000-00042. PMID 10551601.
- ^ a b c Izenwasser, Sari; Amy Hauck Newman; Brian M. Cox; Jonathan L. Katz (January–February 1996). “The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter”. European Journal of Pharmacology (Elsevier) 297 (1–2): 9–17. doi:10.1016/0014-2999(95)00696-6. PMID 8851160.
- ^ Lomenzo, Stacey A.; Jill B. Rhoden; Sari Izzenwasser; Dean Wade; Theresa Kopajtic; Jonathan L. Katz; Mark L. Trudell (2005-03-05). “Synthesis and Biological Evaluation of Meperdine Analogs at Monoamine Transporters”. Journal of Medicinal Chemistry (American Chemical Society) 48 (5): 1336–1343. doi:10.1021/jm0401614. PMID 15743177.
- ^ a b c d “Demerol: Is It the Best Analgesic?” (PDF), Pennsylvania Patient Safety Reporting Service Patient Safety Advisory (Pennsylvania Patient Safety Authority) 3 (2), (June 2006) 2013年4月15日閲覧。
- ^ Davis, Sharon (2004年8月). “Use of pethidine for pain management in the emergency department: a position statement of the NSW Therapeutic Advisory Group”. New South Wales Therapeutic Advisory Group. 2007年1月17日閲覧。
- ^ a b c Latta, Kenneth S.; Brian Ginsberg; Robert L. Barkin (January–February 2002). “Meperidine: A Critical Review”. American Journal of Therapeutics (Lippincott Williams & Wilkins) 9 (1): 53–68. doi:10.1097/00045391-200201000-00010. PMID 11782820.
- ^ “In Brief”. NPS Radar. National Prescribing Service (2005年12月). 2009年12月22日閲覧。
- ^ Walker, Diana J.; James P. Zacny (June 1999). “Subjective, Psychomotor, and Physiological Effects of Cumulative Doses of Opioid µ Agonists in Healthy Volunteers”. The Journal of Pharmacology and Experimental Therapeutics (American Society for Pharmacology and Experimental Therapeutics) 289 (3): 1454–1464. PMID 10336539.
- ^ Molloy, A (2002). “Does pethidine still have a place in therapy?” (PDF). Australian Prescriber (NPS MedicineWise) 25 (1): 12–13.
- ^ Gilson AM, Ryan KM, Joranson DE, Dahl JL (2004). “A reassessment of trends in the medical use and abuse of opioid analgesics and implications for diversion control: 1997-2002”. J Pain Symptom Manage 28 (2): 176–188. doi:10.1016/j.jpainsymman.2004.01.003. PMID 15276196.
- ^ Joranson DE, Gilson AM (2005). “Drug crime is a source of abused pain medications in the United States”. J Pain Symptom Manage 30 (4): 299–301. doi:10.1016/j.jpainsymman.2005.09.001. PMID 16256890.
- ^ a b Lexicon of alcohol and drug terms. Geneva: World Health Organization. (1994). ISBN 92-4-154468-6
- ^ http://pubs.acs.org/doi/suppl/10.1021/jm0401614/suppl_file/jm0401614_s.pdf
- ^ Lomenzo, S.; Rhoden, J.; Izenwasser, S.; Wade, D.; Kopajtic, T.; Katz, J.; Trudell, M. (2005). “Synthesis and biological evaluation of meperidine analogues at monoamine transporters”. Journal of Medicinal Chemistry 48 (5): 1336–1343. doi:10.1021/jm0401614. PMID 15743177.
- ^ Lomenzo, S.; Izenwasser, S.; Gerdes, R. M.; Katz, J. L.; Kopajtic, T.; Trudell, M. L. (1999). “Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine”. Bioorganic & Medicinal Chemistry Letters 9 (23): 3273–3276. doi:10.1016/S0960-894X(99)00606-X.
- ^ Rhoden, J. B.; Bouvet, M.; Izenwasser, S.; Wade, D.; Lomenzo, S. A.; Trudell, M. L. (2005). “Structure-activity studies of 3'-4'-dichloro-meperidine analogues at dopamine and serotonin transporters”. Bioorganic & Medicinal Chemistry 13 (19): 5623–5634. doi:10.1016/j.bmc.2005.05.025. PMID 15993612.
- ^ Gu, X.; Izenwasser, S.; Wade, D.; Housman, A.; Gulasey, G.; Rhoden, J. B.; Savoie, C. D.; Mobley, D. L. et al. (2010). “Synthesis and structure–activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands”. Bioorganic & Medicinal Chemistry 18 (23): 8356. doi:10.1016/j.bmc.2010.09.060.
[続きの解説]
メペリジンと同じ種類の言葉
固有名詞の分類
- メペリジンのページへのリンク
