NCAM
(CD56 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/04/01 09:56 UTC 版)
NCAM（別名: N-CAM、neural cell adhesion molecule、エヌキャム、神経細胞接着分子）は、神経細胞、グリア細胞、骨格筋細胞、ナチュラルキラー細胞（NK細胞）の細胞表面にある「細胞-細胞接着」を担う細胞接着分子・糖タンパク質である。神経軸索伸長、シナプス可塑性、学習、記憶に機能している。CD56（CD分類）、Leu-19、NKH1と同一分子で、免疫グロブリンスーパーファミリー (immunoglobulin superfamily, IgSF)[5] の一員である。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000149294 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039542 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b 免疫グロブリンスーパーファミリー(immunoglobulin superfamily) - 脳科学辞典
- ^ HV. Wilson
- ^ Moscona A (Jan 1957). “THE DEVELOPMENT IN VITRO OF CHIMERIC AGGREGATES OF DISSOCIATED EMBRYONIC CHICK AND MOUSE CELLS”. Proc Natl Acad Sci U S A 43 (1): 184-194. PMID 16589996.
- ^ Rutishauser U, Thiery JP, Brackenbury R, Sela BA, Edelman GM (Feb 1976). “Mechanisms of adhesion among cells from neural tissues of the chick embryo”. Proc Natl Acad Sci U S A 73 (2): 577-581. PMC 335953. PMID 54921.
- ^ J P Thiery, R Brackenbury, U Rutishauser, G M Edelman (Oct 1979). “Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina”. J Biol Chem 252 (19): 6841-6845.
- ^ Brackenbury R, Thiery JP, Rutishauser U, Edelman GM (Oct 1979). “Adhesion among neural cells of the chick embryo. I. An immunological assay for molecules involved in cell-cell binding”. J Biol Chem 252 (19): 6835-6840.
- ^ Bertolotti R, Rutishauser U, Edelman GM (Aug 1980). “A cell surface molecule involved in aggregation of embryonic liver cells”. Proc Natl Acad Sci U S A 77 (8): 4831-4835. PMC 349941. PMID 6933535.
- ^ Murray BA, Hemperly JJ, Gallin WJ, MacGregor JS, Edelman GM, Cunningham BA (Sep 1984). “Isolation of cDNA clones for the chicken neural cell adhesion molecule (N-CAM)”. Proc Natl Acad Sci U S A 81 (17): 5584-5588. PMC 391751. PMID 6089213.
- ^ Cunningham BA, Hemperly JJ, Murray BA, Prediger EA, Brackenbury R, Edelman GM (May 1987). “Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing”. Science 236 (4803): 799-806. PMID 3576199.
- ^ Reyes AA, Small SJ, Akeson R. (1991). “At least 27 alternatively spliced forms of the neural cell adhesion molecule mRNA are expressed during rat heart development”. Mol Cell Biol. 11 (3): 1654-1661. PMC 369464. PMID 1996115.
- ^ Dickson G, Gower HJ, Barton CH, Prentice HM, Elsom VL, Moore SE, Cox RD, Quinn C, Putt W, Walsh FS (Sep 1987). “Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain”. Cell 50 (11): 1119-1130. PMID 2887295.
- ^ Suzuki M, Angata K, Nakayama J, Fukuda M. (2003). “Polysialic acid and mucin type o-glycans on the neural cell adhesion molecule differentially regulate myoblast fusion”. J Biol Chem. 278 (49): 49459-49468. doi:10.1074/jbc.M308316200. PMID 13679364.
- ^ Suzuki M, Angata K, Nakayama J, Fukuda M. (Nov 1990). “Expression of the unique NCAM VASE exon is independently regulated in distinct tissues during development”. J Cell Biol 111 (5): 2089-2096. PMC 2116347. PMID 13679364.
- ^ Chen A, Haines S, Maxson K, Akeson RA (Aug 1994). “VASE exon expression alters NCAM-mediated cell-cell interactions”. J Neurosci Res 38 (5): 483-492. doi:10.1002/jnr.490380502. PMID 7815468.
- ^ Becker, C. G., Artola, A., Gerardy-Schahn, R., Becker, T., Welzl, H., and Schachner, M. (1996). “The polysialic acid modification of the neural cell adhesion molecule is involved in spatial learning and hippocampal long-term potentiation”. J Neurosci Res. 45 (2): 143-152. doi:10.1002/(SICI)1097-4547(19960715)45:2<143::AID-JNR6>3.0.CO;2-A. PMID 8843031.
- ^ Stoenica L, Senkov O, Gerardy-Schahn R, Weinhold B, Schachner M, Dityatev A. (2006). “In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid”. Eur J Neurosci. 23 (9): 2255-2264. doi:10.1111/j.1460-9568.2006.04771.x. PMID 16706834.
- ^ Senkov O, Sun M, Weinhold B, Gerardy-Schahn R, Schachner M, Dityatev A. (2006). “Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm”. J Neurosci. 26 (42): 10888-10898. doi:10.1523/JNEUROSCI.0878-06.2006. PMID 17050727.
- ^ 神経筋接合部 - 脳科学辞典
- ^ Cremer H, Lange R, Christoph A, Plomann M, Vopper G, Roes J, Brown R, Baldwin S, Kraemer P, Scheff S, et al. (Feb 1994). “Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning”. Nature 367 (6462): 455-459. PMID 8107803.
- ^ Chan SA, Polo-Parada L, Landmesser LT, Smith C. (Aug 2005). “Adrenal chromaffin cells exhibit impaired granule trafficking in NCAM knockout mice”. J Neurophysiol 94 (2): 1037-1047. PMID 15800072.
- ^ Brackenbury R, Rutishauser U, Edelman GM (January 1981). “Distinct calcium-independent and calcium-dependent adhesion systems of chicken embryo cells”. Proc. Natl. Acad. Sci. U.S.A. 78 (1): 387-391. doi:10.1073/pnas.78.1.387. PMC 319058. PMID 6165990.
- ^ CD Markers - CD56
- ^ Jensen M, Berthold F. (2007). “Targeting the neural cell adhesion molecule in cancer”. Cancer Lett. 258 (1): 9-21. doi:10.1016/j.canlet.2007.09.004. PMID 17949897.
- ^ テルアビブ大学のEla Markovskyの2012年の講演。講演タイトル「Targeting cancer stem cells with NCAM-assisted delivery of nano-scaled polymer therapeutics」 - YouTube[1] 動画（英語）19分43秒 2013年8月16日閲覧
- ^ Kraev I, Henneberger C, Rossetti C, Conboy L, Kohler LB, Fantin M, Jennings A, Venero C, Popov V, Rusakov D, Stewart MG, Bock E, Berezin V, Sandi C (Aug 2011). “A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus”. PLoS One 6 (8): e23433. doi:10.1371/journal.pone.0023433. PMC 3160849. PMID 21887252.
[続きの解説]
「NCAM」の続きの解説一覧
- 1 NCAMとは
- 2 NCAMの概要
- 3 構造
- 4 遺伝子ノックアウト
- 5 参考文献
- CD56のページへのリンク
