自然リンパ球とは？ わかりやすく解説

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ウィキペディア
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自然リンパ球

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/07/30 15:29 UTC 版)

自然リンパ球（Innate lymphoid cells, ILC) とは共通のリンパ系前駆細胞（CLP）に由来する自然免疫系細胞である。病原性の組織損傷に反応してシグナル分子を分泌し、自然免疫細胞と獲得免疫細胞の両方を制御している。ILCは主に組織内に存在する細胞で、リンパ系組織（免疫関連組織）と非リンパ系組織の両方に存在し、まれに末梢血にも存在する。特に粘膜表面に多く局在し、粘膜の免疫と恒常性の維持に重要な役割を果たしている。リンパ球系に属する自然免疫細胞であるが、抗体特異的な応答はせず、B細胞、およびT細胞受容体を持たない（RAG遺伝子がないため）[1]。通常のリンパ系の形態を持たず、通常の骨髄系細胞や樹状細胞に見られる表現型マーカーを持つ[2]。


脚注

注釈

  1. ^ a b Natural Cytotoxicity triggering Receptor
  2. ^ CD3CD4CD8CD19CD11bCD11cFcεR1NK1.1Gr1−
  3. ^ 分節構造を持つ繊維様の形態の腸内細菌
  4. ^ 組織微小環境の変化に応じて細胞の性質が可逆的に変化すること。
  5. ^ 性質が変化して別種の細胞となる現象。下記参照。

出典

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