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ラミニン

分子式：	C₉H₂₀N₂O₂
その他の名称：	ラミニン、Laminine、5-Amino-5-carboxylato-N,N,N-trimethyl-1-pentanaminium
体系名：	5-アミノ-5-カルボキシラト-N,N,N-トリメチル-1-ペンタンアミニウム

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ラミニン

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/10/11 15:31 UTC 版)

ラミニン（英: laminin）は、細胞外マトリックスの基底膜を構成する巨大なタンパク質である。多細胞体制・組織構築とその維持、細胞接着、細胞移動、細胞増殖を促進し、がん細胞と関係が深い。胚発生の初期（2細胞期）に発現する^[1]。

出典

^ Dziadek, M; et al. (Oct 1985). “Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells”. Dev Biol. 111 (2): 372-82. doi:10.1016/0012-1606(85)90491-9.
^ Orkin RW, Gehron P, McGoodwin EB, Martin GR, Valentine T, Swarm R. (Jan 1977). “A murine tumor producing a matrix of basement membrane”. J Exp Med 145 (1): 204-220. PMC 2180589. PMID 830788.
^ de:Rupert Timpl
^ Timpl R, Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR (Oct 1979). “Laminin--a glycoprotein from basement membranes”. J Biol Chem 254 (19): 9933-9937. PMID 114518.
^ Engel J, Odermatt E, Engel A, Madri JA, Furthmayr H, Rohde H, Timpl R. (July 1981). “Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix”. J. Mol. Biol. 150 (1): 97-120. PMID 6795355.
^ Sasaki M, Kato S, Kohno K, Martin GR, Yamada Y (Feb 1987). “Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats”. Proc Natl Acad Sci U S A 84 (4): 935-939. PMC 304334. PMID 3493487.
^ Sasaki M, Yamada Y (Dec 1987). “The laminin B2 chain has a multidomain structure homologous to the B1 chain”. J Biol Chem 262 (35): 17111-17117. PMID 3680290.
^ Sasaki M, Kleinman HK, Huber H, Deutzmann R, Yamada Y (Nov 1988). “Laminin, a multidomain protein. The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains”. J Biol Chem 263 (32): 16536-16544. PMID 3182802.
^ Terranova VP, Rohrbach DH, Martin GR. (Dec 1980). “Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen”. Cell 22 (3): 719-726.
^ 野水基義 (2000). “ラミニンにはいくつの活性部位があるのか？”. 蛋白質核酸酵素 45 (15): 2475-2482.
^ Mecham RP (Aug 1991). “Receptors for laminin on mammalian cells”. FASEB J 5 (11): 2538-2546. PMID 1651264.
^ Rao NC, Barsky SH, Terranova VP, Liotta LA (Mar 1983). “Isolation of a tumor cell laminin receptor”. Biochem Biophys Res Commun 111 (3): 804-808. PMID 6301485.
^ Castronovo V, Taraboletti G, Sobel ME (Oct 1991). “Functional domains of the 67-kDa laminin receptor precursor”. J Biol Chem 266 (30): 20440-20446. PMID 1834645.
^ Smalheiser NR, Schwartz NB (Sep 1987). “Cranin: a laminin-binding protein of cell membranes”. Proc Natl Acad Sci U S A 84 (18): 6457-6461. PMC 299096. PMID 2957695.
^ Neil R. Smalheiser, Edward Kim (Jun 1995). “Purification of Cranin, a Laminin Binding Membrane Protein. IDENTITY WITH DYSTROGLYCAN AND REASSESSMENT OF ITS CARBOHYDRATE MOIETIES”. J Biol Chem 270: 15425-15433. doi:10.1074/jbc.270.25.15425.
^ Choi ES, Sullivan PD, Clegg DO (Feb 1991). “Evidence against a laminin receptor role for calsequestrin”. Biochem Biophys Res Commun 174 (3): 1208-1216. PMID 1825466.
^ ^a ^b Tisi D, Talts JF, Timpl R, Hohenester E (April 2000). “Structure of the C-terminal laminin G-like domain pair of the laminin alpha2 chain harbouring binding sites for alpha-dystroglycan and heparin”. EMBO J. 19 (7): 1432-1440. doi:10.1093/emboj/19.7.1432. PMC 310212. PMID 10747011.
^ Beckmann G, Hanke J, Bork P, Reich JG (February 1998). “Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins”. J. Mol. Biol. 275 (5): 725-730. doi:10.1006/jmbi.1997.1510. PMID 9480764.
^ Engel J (July 1989). “EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation?”. FEBS Lett. 251 (1-2): 1-7. doi:10.1016/0014-5793(89)81417-6. PMID 2666164.
^ ^a ^b Stetefeld J, Mayer U, Timpl R, Huber R (April 1996). “Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site”. J. Mol. Biol. 257 (3): 644-657. doi:10.1006/jmbi.1996.0191. PMID 8648630.
^ ^a ^b Baumgartner R, Czisch M, Mayer U, Poschl E, Huber R, Timpl R, Holak TA (April 1996). “Structure of the nidogen binding LE module of the laminin gamma1 chain in solution”. J. Mol. Biol. 257 (3): 658-668. doi:10.1006/jmbi.1996.0192. PMID 8648631.
^ Mayer U, Poschl E, Gerecke DR, Wagman DW, Burgeson RE, Timpl R (May 1995). “Low nidogen affinity of laminin-5 can be attributed to two serine residues in EGF-like motif gamma 2III4”. FEBS Lett. 365 (2-3): 129-132. doi:10.1016/0014-5793(95)00438-F. PMID 7781764.
^ ^a ^b Yurchenco PD, Cheng YS (August 1993). “Self-assembly and calcium-binding sites in laminin. A three-arm interaction model”. J. Biol. Chem. 268 (23): 17286-17299. PMID 8349613.
^ Xu H, Wu XR, Wewer UM, Engvall E (November 1994). “Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene”. Nat. Genet. 8 (3): 297-302. doi:10.1038/ng1194-297. PMID 7874173.
^ Leivo I, Engvall E (Mar 1988). “Merosin, a protein specific for basement membranes of Schwann cells, striated muscle, and trophoblast, is expressed late in nerve and muscle development”. Proc Natl Acad Sci U S A 85 (5): 1544-1548. PMC 279809. PMID 3278318.
^ Hunter DD, Shah V, Merlie JP, Sanes JR. (Mar 1989). “A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction”. Nature 338 (6212): 229-234. PMID 2922051.
^ ^a ^b 細胞接着分子 - 脳科学辞典
^ Aumailley, M; et al. (Aug 2005). “A simplified laminin nomenclature”. Matrix Biol. 24 (5): 326-32. doi:10.1016/j.matbio.2005.05.006.
^ http://www.lm.lncc.br/nomenclatures 2013年8月10日閲覧
^ Golbert, Daiane C F; Linhares-Lacerda Leandra, Almeida Luiz G, Correa-de-Santana Eliane, de Oliveira Alice R, Mundstein Alex S, Savino Wilson, de Vasconcelos Ana T R (Jan 2011). “Laminin database: a tool to retrieve high-throughput and curated data for studies on laminins” (英語). Nucleic Acids Res. (England) 39 (Database issue): D320-3. doi:10.1093/nar/gkq1055. PMC 3013663. PMID 21087995.
^ Tzu J, Marinkovich MP (2008). “Bridging structure with function: structural, regulatory, and developmental role of laminins”. Int J Biochem Cell Biol 40 (2): 199-214. PMC 2192629. PMID 17855154.
^ Colognato H, Yurchenco P (2000). “Form and function: the laminin family of heterotrimers”. Dev. Dyn. 218 (2): 213-234. doi:10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R. PMID 10842354.
^ Erhard Hohenester, Peter D. Yurchenco (January 2013). “Laminins in basement membrane assembly”. Cell Adh Migr 7 (1): 56-63. doi:10.4161/cam.21831. PMC 3544787.
^ Beck K, Hunter I, Engel J (February 1990). “Structure and function of laminin: anatomy of a multidomain glycoprotein”. FASEB J. 4 (2): 148-160. PMID 2404817.
^ Kikkawa Y, Hozumi K, Katagiri F, Nomizu M, Kleinman HK, Koblinski JE (January 2013). “Laminin-111-derived peptides and cancer”. Cell Adh Migr 7 (1): 150-56-63. doi:10.4161/cam.22827. PMC 3544779. PMID 23263633.
^ Thyboll, J; et al. (Feb 2002). “Deletion of the laminin alpha4 chain leads to impaired microvessel maturation”. Mol Cell Biol. 22 (4): 1194-202. PMID 11809810.
^ OMIM#609049 Pierson syndrome(2012/3/19閲覧)
^ Zenker, M; et al. (Nov 2004). “Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities”. Hum Mol Genet. 13 (21): 2625-32. PMID 15367484.
^ Matejas, V; et al. (Sep 2010). “Mutations in the human laminin beta2 (LAMB2) gene and the associated phenotypic spectrum”. Hum Mutat. 31 (9): 992-1002. PMID 20556798.
^ Dainichi, T; et al. (Feb 2009). “Anti-laminin gamma-1 pemphigoid”. Proc Natl Acad Sci U S A. 106 (8): 2800-5. PMID 19196964.
^ Hayashi, I; et al. (2011 published online). “Mucous membrane pemphigoid with generalized blisters: IgA and IgG autoantibodies target both laminin-332 and type XVII collagen”. Br J Dermatol.. doi:10.1111/j.1365-2133.2011.10776.x. PMID 22182184.
^ Domogatskaya, A; et al. (Nov 2008). “Laminin-511 but not -332, -111, or -411 enables mouse embryonic stem cell self-renewal in vitro”. Stem Cells. 26 (11): 2800-9.
^ Miyazaki, T; et al. (Oct 2008). “Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells”. Biochem Biophys Res Commun. 375 (1): 27-32. doi:10.1016/j.bbrc.2008.07.111.
^ Rodin, S; et al. (Jun 2010). “Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511”. Nat Biotechnol. 28 (6): 611-5. doi:10.1038/nbt.1620.
^ Karl Tryggvason (May 2013). “Biologically Relevant Laminins. Key to Derivation and Culture of Stem Cells and Differentiated Cells Lies with These ECM Proteins”. Genetic Engineering & Biotechnology News 33 (9).
^ 特許研究室
^ Kobayashi N, Yoshida T (2007). “Binding sites on laminin receptors as components for antibiotics”. Protein Pept Lett 14 (1): 33-36. PMID 17266648.
^ 小林菜穂子、吉田徹彦 (2009). “ラミニンレセプターのラミニン結合部位を基にした抗菌ペプチドの設計”. 東亜合成研究年報.

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