プソラレン【psoralen】
読み方：ぷそられん
⇒ソラレン
プソラレン
ソラレン
(プソラレン から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/02/10 10:12 UTC 版)
ソラレン(Psoralen)は、直線型フラノクマリンとして知られる天然に存在する有機化合物の母核構造である。構造的には、クマリンにフラン環が融合しており、ウンベリフェロンの誘導体と考えることもできる。オランダビユ(Psoralea corylifolia)の種子に含まれる他、イチジクの葉、セロリ、パセリ、サンショウ、全ての柑橘類にも含まれる。乾癬、皮膚炎、尋常性白斑、皮膚T細胞性リンパ腫等の治療のためPUVA療法（ソラレンとUVAの併用）に広く用いられる。多くのフラノクマリンは魚類にとって猛毒で、インドネシアでは小川に投じて魚を捕まえるのに用いられる。
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- ^ “The benefits and risks of long-term PUVA photochemotherapy”. Dermatol Clin 16 (2): 227-34. (April 1998). doi:10.1016/S0733-8635(05)70005-X. PMID 9589196.
- ^ “Alopecia Areata: Psoralen With Ultraviolet A Light (PUVA) Therapy-Topic Overview” (英語). WebMD 2016年11月10日閲覧。
- ^ M. J. Ashwood-Smith; G. A. Poulton; M. Barker; M. Mildenberger E (1980). “5-Methoxypsoralen, an ingredient in several suntan preparations, has lethal, mutagenic and clastogenic properties”. Nature 285 (5): 407-9. doi:10.1038/285407a0. PMID 6991953.
- ^ “5-Methoxypsoralen, the melanogenic additive in suntan preparations, is tumorigenic in mice exposed to 365 nm UV radiation”. Carcinogenesis 2 (2): 121-7. (1981). doi:10.1093/carcin/2.2.121. PMID 7273295.
- ^ a b Autier P.; Dore J.-F.; Cesarini J.-P. (1997). “Should subjects who used psoralen suntan activators be screened for melanoma?”. Annals of Oncology 8 (5): 435-7. doi:10.1023/A:1008205513771. PMID 9233521.
- ^ “Psoralens used for cosmetic sun tanning: an unusual cause of extensive burn injury”. Burns 22 (8): 633-5. (December 1996). doi:10.1016/S0305-4179(96)00028-9. PMID 8982544.
- ^ Shenoi, Shrutakirthi D.; Prabhu, Smitha; Indian Association of Dermatologists, Venereologists and Leprologists (November 2014). “Photochemotherapy (PUVA) in psoriasis and vitiligo”. Indian Journal of Dermatology, Venereology and Leprology 80 (6): 497-504. doi:10.4103/0378-6323.144143. ISSN 0973-3922. PMID 25382505.
- ^ Ciaravino V, McCullough T, Dayan AD: Pharmacokinetic and toxicology assessment of INTERCEPT (S-59 and UVA treated)platelets. Human Exp Toxicol 2001;20:533-550
- ^ Osselaer (2009). “Universal adoption of pathogen inactivation of platelet components: impact on platelet and red blood cell component use”. Transfusion 49 (7): 1412-1422. doi:10.1111/j.1537-2995.2009.02151.x. PMID 19389022.
- ^ Cazenave (2010). “An active hemovigilance program characterizing the safety profile of 7,483 transfusions with plasma components prepared with amotosalen and UVA photochemical treatment”. Transfusion 50 (6): 1210-1219. doi:10.1111/j.1537-2995.2009.02579.x. PMID 20113450.
- ^ https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427111.htm
- ^ https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427500.htm
- ^ Alexandru D. Buhimschi; Francis P. Gasparro (September 2013). “UVA and UVB-Induced 8-Methoxypsoralen Photoadducts and a Novel Method for their Detection by Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF MS).”. Journal of Photochemistry and Photobiology 90 (1): 241-246. doi:10.1111/php.12171. PMID 24102188.
- ^ Gasparro, editor, Francis P. (1988). Gasparro, Francis. ed. Psoralen DNA photobiology. Boca Raton, Fl.: CRC Press. ISBN 978-0-8493-4379-7
- ^ Wenle Xia; David Gooden; Leihua Liu; Sumin Zhao; Erik J. Soderblom; Eric J. Toone; Wayne F. Beyer Jr; Harold Walder et al. (February 14, 2014). Cheng, Jin. ed. “Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis”. PLoS ONE 9 (2): e88983. doi:10.1371/journal.pone.0088983. PMC 3925176. PMID 24551203.
- ^ Alexander Schmitz; Ananthakrishnan Sankaranarayanan; Philippe Azam; Kristina Schmidt-Lassen; Daniel Homerick; Wolfram Hansel; Heike Wulff (November 2005). “Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.”. Molecular Pharmacology 68 (5): 1254-1270. doi:10.1124/mol.105.015669. PMID 16099841.
- ^ “Dr. Duke's Phytochemical and Ethnobotanical Databases”. U.S. Department of Agriculture, Agricultural Research Service. 2018年10月6日閲覧。
- ^ “Removal of psoralen interstrand cross-links from DNA of Escherichia coli: mechanism and genetic control”. J. Mol. Biol. 103 (1): 39-59. (1976). doi:10.1016/0022-2836(76)90051-6. PMID 785009.
- ^ a b “Repair of cross-linked DNA and survival of Escherichia coli treated with psoralen and light: effects of mutations influencing genetic recombination and DNA metabolism”. J. Bacteriol. 136 (2): 538-47. (1978). PMC 218577. PMID 361714.
- ^ “Induction of direct repeat recombination by psoralen-DNA adducts in Saccharomyces cerevisiae: defects in DNA repair increase gene copy number variation”. DNA Repair (Amst.) 21: 87-96. (2014). doi:10.1016/j.dnarep.2014.05.011. PMID 24969513.
- ^ “Repair of psoralen-induced crosslinks in cells multiply infected with SV40”. Mol. Gen. Genet. 188 (1): 135-8. (1982). doi:10.1007/bf00333007. PMID 6294477.
- ^ “Repair of psoralen-treated DNA by genetic recombination in human cells infected with herpes simplex virus”. Cancer Res. 41 (12 Pt 1): 5033-8. (1981). PMID 6272987.
- ^ “Psoralens as Photoactive Probes of Nucleic Acid Structure and Function: Organic Chemistry, Photochemistry, and Biochemistry”. Annual Review of Biochemistry 54: 1151-1193. (1985). doi:10.1146/annurev.bi.54.070185.005443. PMID 2411210.
- ^ “RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure”. Cell 165 (5): 1267-1279. (2016). doi:10.1016/j.cell.2016.04.028. PMC 5029792. PMID 27180905.
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