Brafとは - わかりやすく解説 Weblio辞書

BRAF

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/12/08 14:25 UTC 版)

BRAFまたはB-Rafは、ヒトではBRAF遺伝子にコードされるタンパク質である^[5]^[6]。その名称は"v-raf murine sarcoma viral oncogene homolog B"の略号に由来する。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157764 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002413 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies”. Oncogene 5 (12): 1775–80. (December 1990). PMID 2284096.
^ “B-raf and a B-raf pseudogene are located on 7q in man”. Oncogene 7 (4): 795–9. (April 1992). PMID 1565476.
^ “Mutations of the BRAF gene in human cancer”. Nature 417 (6892): 949–54. (June 2002). Bibcode: 2002Natur.417..949D. doi:10.1038/nature00766. PMID 12068308.
^ “FDA Approves Zelboraf (Vemurafenib) and Companion Diagnostic for BRAF Mutation-Positive Metastatic Melanoma, a Deadly Form of Skin Cancer” (プレスリリース), Genentech 2011年8月17日閲覧。
^ “Twenty years on: the impact of fragments on drug discovery”. Nature Reviews. Drug Discovery 15 (9): 605–619. (September 2016). doi:10.1038/nrd.2016.109. PMID 27417849.
^ ^a ^b “Entrez Gene: BRAF”. 2022年10月16日閲覧。
^ “The ins and outs of Raf kinases”. Trends in Biochemical Sciences 19 (11): 474–80. (November 1994). doi:10.1016/0968-0004(94)90133-3. PMID 7855890.
^ ^a ^b ^c ^d “Autoregulation of the Raf-1 serine/threonine kinase”. Proceedings of the National Academy of Sciences of the United States of America 95 (16): 9214–9. (August 1998). Bibcode: 1998PNAS...95.9214C. doi:10.1073/pnas.95.16.9214. PMC 21318. PMID 9689060.
^ ^a ^b ^c “Vemurafenib: the first drug approved for BRAF-mutant cancer”. Nature Reviews. Drug Discovery 11 (11): 873–86. (November 2012). doi:10.1038/nrd3847. PMID 23060265.
^ ^a ^b ^c ^d “Serine/threonine protein kinase B-rAF”. 2013年3月4日閲覧。
^ ^a ^b “The complexity of Raf-1 regulation”. Current Opinion in Cell Biology 9 (2): 174–9. (April 1997). doi:10.1016/S0955-0674(97)80060-9. PMID 9069260.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l “Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification”. FASEB Journal 9 (8): 576–96. (May 1995). doi:10.1096/fasebj.9.8.7768349. PMID 7768349.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ . Cancer Genome Project“Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF”. Cell 116 (6): 855–67. (March 2004). doi:10.1016/S0092-8674(04)00215-6. PMID 15035987.
^ ^a ^b ^c ^d ^e ^f “Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity”. Proceedings of the National Academy of Sciences of the United States of America 105 (8): 3041–6. (February 2008). Bibcode: 2008PNAS..105.3041T. doi:10.1073/pnas.0711741105. PMC 2268581. PMID 18287029.
^ ^a ^b ^c ^d ^e “Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma”. Nature 467 (7315): 596–9. (September 2010). Bibcode: 2010Natur.467..596B. doi:10.1038/nature09454. PMC 2948082. PMID 20823850.
^ “The protein kinase family: conserved features and deduced phylogeny of the catalytic domains”. Science 241 (4861): 42–52. (July 1988). Bibcode: 1988Sci...241...42H. doi:10.1126/science.3291115. PMID 3291115.
^ “Eukaryotic protein kinases”. Curr. Opin. Struct. Biol. 1 (3): 369–383. (June 1991). doi:10.1016/0959-440X(91)90035-R.
^ “[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members”. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods in Enzymology. 200. (1991). pp. 38–62. doi:10.1016/0076-6879(91)00126-H. ISBN 9780121821012. PMID 1956325
^ “Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation”. The EMBO Journal 18 (8): 2137–48. (April 1999). doi:10.1093/emboj/18.8.2137. PMC 1171298. PMID 10205168.
^ “The cardiofaciocutaneous syndrome”. Journal of Medical Genetics 43 (11): 833–42. (November 2006). doi:10.1136/jmg.2006.042796. PMC 2563180. PMID 16825433.
^ “Real-time PCR-based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia”. Hematological Oncology 30 (4): 190–3. (December 2012). doi:10.1002/hon.1023. PMID 22246856.
^ “EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome”. Genetics in Medicine 11 (1): 42–65. (January 2009). doi:10.1097/GIM.0b013e31818fa2db. PMC 2743613. PMID 19125127.
^ “Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers”. The Journal of Clinical Endocrinology and Metabolism 88 (9): 4393–7. (September 2003). doi:10.1210/jc.2003-030305. PMID 12970315.
^ “Detection of BRAF V600E mutation by pyrosequencing”. Pathology 40 (3): 295–8. (April 2008). doi:10.1080/00313020801911512. PMID 18428050.
^ ^a ^b “BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status”. Molecular Cancer 5 (1): 2. (January 2006). doi:10.1186/1476-4598-5-2. PMC 1360090. PMID 16403224.
^ “Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology”. The Journal of Molecular Diagnostics 8 (5): 540–3. (November 2006). doi:10.2353/jmoldx.2006.060070. PMC 1876165. PMID 17065421.
^ “BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer”. Clinical Cancer Research 10 (1 Pt 1): 191–5. (January 2004). doi:10.1158/1078-0432.CCR-1118-3. PMID 14734469.
^ “BRAF mutations in conjunctival melanoma”. Investigative Ophthalmology & Visual Science 45 (8): 2484–8. (August 2004). doi:10.1167/iovs.04-0093. PMID 15277467.
^ “Determinants of BRAF mutations in primary melanomas”. Journal of the National Cancer Institute 95 (24): 1878–90. (December 2003). doi:10.1093/jnci/djg123. PMID 14679157.
^ “BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas”. The Journal of Clinical Endocrinology and Metabolism 89 (5): 2414–20. (May 2004). doi:10.1210/jc.2003-031425. PMID 15126572.
^ “BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study”. The Journal of Clinical Endocrinology and Metabolism 93 (10): 3943–9. (October 2008). doi:10.1210/jc.2008-0607. PMID 18682506.
^ “Recent advances in the understanding of Langerhans cell histiocytosis”. British Journal of Haematology 156 (2): 163–72. (January 2012). doi:10.1111/j.1365-2141.2011.08915.x. PMID 22017623.
^ Tiacci, Enrico; Trifonov, Vladimir; Schiavoni, Gianluca; Holmes, Antony; Kern, Wolfgang; Martelli, Maria Paola; Pucciarini, Alessandra; Bigerna, Barbara et al. (2011-06-16). “BRAF mutations in hairy-cell leukemia”. The New England Journal of Medicine 364 (24): 2305–2315. doi:10.1056/NEJMoa1014209. ISSN 1533-4406. PMC 3689585. PMID 21663470.
^ “Research on hairy-cell leukaemia shows the promise of new DNA-scanning technologies”. Cancer Research UK. 2022年11月3日閲覧。
^ “High frequency of BRAF V600E mutations in ameloblastoma”. The Journal of Pathology 232 (5): 492–8. (April 2014). doi:10.1002/path.4317. PMC 4255689. PMID 24374844.
^ Brastianos, Priscilla K.; Taylor-Weiner, Amaro; Manley, Peter E.; Jones, Robert T.; Dias-Santagata, Dora; Thorner, Aaron R.; Lawrence, Michael S.; Rodriguez, Fausto J. et al. (2014-02). “Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas”. Nature Genetics 46 (2): 161–165. doi:10.1038/ng.2868. ISSN 1546-1718. PMC 3982316. PMID 24413733.
^ “Single driver mutation found in rare brain tumor” (英語). Broad Institute (2014年1月30日). 2022年11月3日閲覧。
^ “BRAF V600E is a determinant of sensitivity to proteasome inhibitors”. Molecular Cancer Therapeutics 12 (12): 2950–61. (December 2013). doi:10.1158/1535-7163.MCT-13-0243. hdl:2318/140935. PMID 24107445.
^ “Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885”. Cancer Research 66 (23): 11100–5. (December 2006). doi:10.1158/0008-5472.CAN-06-2554. PMID 17145850.
^ . BRIM-3 Study Group“Improved survival with vemurafenib in melanoma with BRAF V600E mutation”. The New England Journal of Medicine 364 (26): 2507–16. (June 2011). doi:10.1056/NEJMoa1103782. PMC 3549296. PMID 21639808.
^ ^a ^b “Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance”. Nature 494 (7436): 251–5. (February 2013). Bibcode: 2013Natur.494..251D. doi:10.1038/nature11814. PMC 3930354. PMID 23302800.
^ “Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation”. Nature 468 (7326): 973–7. (December 2010). Bibcode: 2010Natur.468..973N. doi:10.1038/nature09626. PMC 3143360. PMID 21107323.
^ “Negative regulation of the serine/threonine kinase B-Raf by Akt”. The Journal of Biological Chemistry 275 (35): 27354–9. (September 2000). doi:10.1074/jbc.M004371200. PMID 10869359.
^ “Active Ras induces heterodimerization of cRaf and BRaf”. Cancer Research 61 (9): 3595–8. (May 2001). PMID 11325826.
^ “Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells”. Molecular and Cellular Biology 17 (6): 3047–55. (June 1997). doi:10.1128/MCB.17.6.3047. PMC 232157. PMID 9154803.
^ “Biochemical analysis of MEK activation in NIH3T3 fibroblasts. Identification of B-Raf and other activators”. The Journal of Biological Chemistry 270 (13): 7644–55. (March 1995). doi:10.1074/jbc.270.13.7644. PMID 7706312.
^ “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology 3 (1): 89. (2007). doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ “Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins”. The Journal of Biological Chemistry 275 (41): 31921–9. (October 2000). doi:10.1074/jbc.M003327200. PMID 10931830.

「BRAF」の続きの解説一覧

Brafのページへのリンク

Brafとは？わかりやすく解説

BRAF

「Braf」の関連用語

Brafとは？ わかりやすく解説

BRAF

急上昇のことば

「Braf」の関連用語

Brafとは？わかりやすく解説