核酸の三次構造とは - わかりやすく解説 Weblio辞書

核酸の三次構造

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/03/22 16:12 UTC 版)

核酸の三次構造（かくさんのさんじこうぞう）とは、核酸ポリマーの三次元的形状を指す^[1]。RNAとDNAの分子は、分子認識や触媒などさまざまな機能を有する。このような機能を発揮するには正確な三次構造を取る必要がある。その構造は多様で一見複雑であるものの、簡単に認識できる三次構造モチーフがビルディングブロックとなって構成されている。ここではRNAとDNAの三次構造の最も一般的なモチーフの一部について記述するが、これらの情報は限られた数の既知構造に基づいている。新たなRNAやDNA分子の構造が解明されれば、さらに多くの三次構造モチーフが明らかとなるであろう。

出典

^ IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). オンライン版: (2006-) "tertiary structure".
^ “The structure of DNA in the nucleosome core”. Nature 423 (6936): 145–50. (May 2003). Bibcode: 2003Natur.423..145R. doi:10.1038/nature01595. PMID 12736678.
^ “Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid” (PDF). Nature 171 (4356): 737–8. (April 1953). Bibcode: 1953Natur.171..737W. doi:10.1038/171737a0. PMID 13054692.
^ Bansal M (2003). “DNA structure: Revisiting the Watson-Crick double helix”. Current Science 85 (11): 1556–1563.
^ “A glossary of DNA structures from A to Z”. Acta Crystallogr D 59 (4): 620–626. (2003). doi:10.1107/S0907444903003251. PMID 12657780.
^ ^a ^b ^c ^d PDB 3BWP; “Crystal structure of a self-spliced group II intron”. Science 320 (5872): 77–82. (April 2008). Bibcode: 2008Sci...320...77T. doi:10.1126/science.1153803. PMC 4406475. PMID 18388288. ; rendered with PyMOL
^ ^a ^b PDB 2K95; “Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA”. J. Mol. Biol. 384 (5): 1249–61. (December 2008). doi:10.1016/j.jmb.2008.10.005. PMC 2660571. PMID 18950640. ; rendered with PyMOL
^ ^a ^b “A universal mode of helix packing in RNA”. Nat. Struct. Biol. 8 (4): 339–43. (April 2001). doi:10.1038/86221. PMID 11276255.
^ “A minor groove RNA triple helix within the catalytic core of a group I intron”. Nat. Struct. Biol. 5 (12): 1037–42. (December 1998). doi:10.1038/4146. PMID 9846872.
^ “A tertiary interaction that links active-site domains to the 5' splice site of a group II intron”. Nature 406 (6793): 315–8. (July 2000). doi:10.1038/35018589. PMID 10917534.
^ ^a ^b ^c PDB 1RAU; “Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures”. Biochemistry 31 (36): 8406–14. (September 1992). doi:10.1021/bi00151a003. PMID 1382577. ; rendered with PyMOL
^ ^a ^b PDB 1FIT; “2.8 A crystal structure of the malachite green aptamer”. J. Mol. Biol. 301 (1): 117–28. (August 2000). doi:10.1006/jmbi.2000.3951. PMID 10926496. ; rendered with PyMOL
^ “Structure of the SAM-II riboswitch bound to S-adenosylmethionine”. Nat. Struct. Mol. Biol. 15 (2): 177–82. (February 2008). doi:10.1038/nsmb.1371. PMID 18204466.
^ ^a ^b “Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine”. Nature 432 (7015): 411–5. (November 2004). Bibcode: 2004Natur.432..411B. doi:10.1038/nature03037. PMID 15549109.
^ “Functional and dysfunctional roles of quadruplex DNA in cells”. Chem. Biol. 8 (3): 221–30. (March 2001). doi:10.1016/S1074-5521(01)00007-2. PMID 11306347.
^ “Preferential binding of fd gene 5 protein to tetraplex nucleic acid structures”. J. Mol. Biol. 301 (3): 575–84. (August 2000). doi:10.1006/jmbi.2000.3991. PMID 10966771.
^ PDB 6tna; “Crystal structure of yeast phenylalanine transfer RNA. I. Crystallographic refinement”. J. Mol. Biol. 123 (4): 607–30. (August 1978). doi:10.1016/0022-2836(78)90209-7. PMID 357742. ; rendered via PyMOL.
^ ^a ^b “Structural domains of transfer RNA molecules”. Science 194 (4267): 796–806. (November 1976). Bibcode: 1976Sci...194..796Q. doi:10.1126/science.790568. PMID 790568.
^ Turner, Douglas H.; Mathews, David H. (2010-1). “NNDB: the nearest neighbor parameter database for predicting stability of nucleic acid secondary structure”. Nucleic Acids Research 38 (Database issue): D280–D282. doi:10.1093/nar/gkp892. ISSN 0305-1048. PMC 2808915. PMID 19880381.
^ “Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding”. Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9218–22. (September 1994). Bibcode: 1994PNAS...91.9218W. doi:10.1073/pnas.91.20.9218. PMC 44783. PMID 7524072.
^ “Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme”. Science 265 (5179): 1709–12. (September 1994). Bibcode: 1994Sci...265.1709M. doi:10.1126/science.8085157. PMID 8085157.
^ ^a ^b ^c “Crystal structure of a group I ribozyme domain: principles of RNA packing”. Science 273 (5282): 1678–85. (September 1996). Bibcode: 1996Sci...273.1678C. doi:10.1126/science.273.5282.1678. PMID 8781224.
^ Noller HF (September 2005). “RNA structure: reading the ribosome”. Science 309 (5740): 1508–14. Bibcode: 2005Sci...309.1508N. doi:10.1126/science.1111771. PMID 16141058.
^ “The solution structure of an RNA loop-loop complex: the ColE1 inverted loop sequence”. Structure 6 (8): 993–1005. (August 1998). doi:10.1016/S0969-2126(98)00101-4. PMID 9739090.
^ “Crystal structure of a hepatitis delta virus ribozyme”. Nature 395 (6702): 567–74. (October 1998). Bibcode: 1998Natur.395..567F. doi:10.1038/26912. PMID 9783582.
^ Rothemund, Paul W. K. (2006). “Folding DNA to create nanoscale shapes and patterns”. Nature 440 (7082): 297–302. Bibcode: 2006Natur.440..297R. doi:10.1038/nature04586. ISSN 0028-0836. PMID 16541064.
^ ^a ^b ^c ^d PDB 1GID; “Crystal structure of a group I ribozyme domain: principles of RNA packing”. Science 273 (5282): 1678–85. (September 1996). Bibcode: 1996Sci...273.1678C. doi:10.1126/science.273.5282.1678. PMID 8781224. ; rendered with PyMOL
^ “Selection for thermodynamically stable DNA tetraloops using temperature gradient gel electrophoresis reveals four motifs: d(cGNNAg), d(cGNABg),d(cCNNGg), and d(gCNNGc)”. Biochemistry 41 (48): 14281–92. (December 2002). doi:10.1021/bi026479k. PMID 12450393.
^ “Remarkable morphological variability of a common RNA folding motif: the GNRA tetraloop-receptor interaction”. J. Mol. Biol. 266 (3): 493–506. (February 1997). doi:10.1006/jmbi.1996.0810. PMID 9067606.
^ “Evidence that folding of an RNA tetraloop hairpin is less cooperative than its DNA counterpart”. Biochemistry 43 (25): 7992–8. (June 2004). doi:10.1021/bi049350e. PMID 15209494.
^ Nucleic Acids in Chemistry and Biology. Cambridge, UK: RSC Pub. (2006). ISBN 0-85404-654-2
^ ^a ^b “Involvement of a GNRA tetraloop in long-range RNA tertiary interactions”. J. Mol. Biol. 236 (5): 1271–6. (March 1994). doi:10.1016/0022-2836(94)90055-8. PMID 7510342.
^ “Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis”. J. Mol. Biol. 216 (3): 585–610. (December 1990). doi:10.1016/0022-2836(90)90386-Z. PMID 2258934.
^ ^a ^b PDB 1FFK; “The complete atomic structure of the large ribosomal subunit at 2.4 A resolution”. Science 289 (5481): 905–20. (August 2000). Bibcode: 2000Sci...289..905B. doi:10.1126/science.289.5481.905. PMID 10937989. ; rendered with PyMOL
^ “RNA tertiary interactions in the large ribosomal subunit: the A-minor motif”. Proc. Natl. Acad. Sci. U.S.A. 98 (9): 4899–903. (April 2001). Bibcode: 2001PNAS...98.4899N. doi:10.1073/pnas.081082398. PMC 33135. PMID 11296253.
^ “Recognition of the codon-anticodon helix by ribosomal RNA”. Science 285 (5434): 1722–5. (September 1999). doi:10.1126/science.285.5434.1722. PMID 10481006.
^ “A hierarchical model for evolution of 23S ribosomal RNA”. Nature 457 (7232): 977–80. (February 2009). Bibcode: 2009Natur.457..977B. doi:10.1038/nature07749. PMID 19225518.
^ “Tertiary Motifs in RNA Structure and Folding”. Angew. Chem. Int. Ed. Engl. 38 (16): 2326–2343. (August 1999). doi:10.1002/(SICI)1521-3773(19990816)38:16<2326::AID-ANIE2326>3.0.CO;2-3. PMID 10458781.
^ “Sequence and structural conservation in RNA ribose zippers”. J. Mol. Biol. 320 (3): 455–74. (July 2002). doi:10.1016/S0022-2836(02)00515-6. PMID 12096903.
^ PDB 3IGI; “Tertiary architecture of the Oceanobacillus iheyensis group II intron”. RNA 16 (1): 57–69. (January 2010). doi:10.1261/rna.1844010. PMC 2802037. PMID 19952115. ; rendered using PyMOL.
^ PDB 1ZZN; “Structural evidence for a two-metal-ion mechanism of group I intron splicing”. Science 309 (5740): 1587–90. (September 2005). Bibcode: 2005Sci...309.1587S. doi:10.1126/science.1114994. PMID 16141079. ; rendered with PyMOL
^ “Visualizing the higher order folding of a catalytic RNA molecule”. Science 251 (4992): 401–7. (January 1991). Bibcode: 1991Sci...251..401C. doi:10.1126/science.1989074. PMID 1989074.
^ Pyle AM (September 2002). “Metal ions in the structure and function of RNA”. J. Biol. Inorg. Chem. 7 (7–8): 679–90. doi:10.1007/s00775-002-0387-6. PMID 12203005.
^ Morrow, Janet R.; Andolina, Christopher M. (2012). “Chapter 6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids”. Interplay between Metal Ions and Nucleic Acids. Metal Ions in Life Sciences. 10. Springer. pp. 171–197. doi:10.1007/978-94-007-2172-2_6
^ “Metal-binding sites in the major groove of a large ribozyme domain”. Structure 4 (10): 1221–9. (October 1996). doi:10.1016/S0969-2126(96)00129-3. PMID 8939748.
^ “Solution structure of a metal-binding site in the major groove of RNA complexed with cobalt (III) hexammine”. Structure 5 (5): 713–21. (May 1997). doi:10.1016/S0969-2126(97)00225-6. PMID 9195889.
^ “Solution structure of Cobalt(III)hexammine complexed to the GAAA tetraloop, and metal-ion binding to G·A mismatches”. J. Mol. Biol. 295 (5): 1211–23. (February 2000). doi:10.1006/jmbi.1999.3421. PMID 10653698.
^ “Modelling ion binding to AA platform motifs in RNA: a continuum solvent study including conformational adaptation”. Nucleic Acids Res. 29 (19): 3910–8. (October 2001). doi:10.1093/nar/29.19.3910. PMC 60250. PMID 11574672.
^ “A pivotal role for the structure of the Holliday junction in DNA branch migration”. The EMBO Journal 14 (8): 1819–26. (April 1995). doi:10.1002/j.1460-2075.1995.tb07170.x. PMC 398275. PMID 7737132.
^ “DNA double-crossover molecules”. Biochemistry 32 (13): 3211–20. (April 1993). doi:10.1021/bi00064a003. PMID 8461289.

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