ぶんし‐にんしき【分子認識】
分子認識
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/12/11 04:27 UTC 版)
分子認識（ぶんしにんしき、英: molecular recognition）とは、2つもしくはそれ以上の分子が特異的に示す、水素結合、配位結合、疎水効果[3][4]、ファンデルワールス力, π-π相互作用、ハロゲン結合、静電気力[5]などによる相互作用を示す。これらの「直接」相互作用に加え、溶液中における分子認識には溶媒も重要な「間接」作用を持つことがある[6][7]。分子認識におけるホスト・ゲスト分子は分子相補性を示す[8][9]。
- ^ Knox, James R.; Pratt, R. F. (July 1990). “Different modes of vancomycin and D-alanyl-D-alanine peptidase binding to cell wall peptide and a possible role for the vancomycin resistance protein” (Free full text). Antimicrobial Agents and Chemotherapy 34 (7): 1342–7. doi:10.1128/AAC.34.7.1342. PMC 175978. PMID 2386365.
- ^ Bielawski, Christopher; Chen, Yuan-Shek; Zhang, Peng; Prest, Peggy-Jean; Moore, Jeffrey S. (1998). “A modular approach to constructing multi-site receptors for isophthalic acid” (Free full text). Chemical Communications (12): 1313–4. doi:10.1039/a707262g.
- ^ a b Lockett, Matthew R.; Lange, Heiko; Breiten, Benjamin; Heroux, Annie; Sherman, Woody; Rappoport, Dmitrij; Yau, Patricia O.; Snyder, Philip W. et al. (2013). “The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand”. Angewandte Chemie International Edition 52 (30): 7714–7717. doi:10.1002/anie.201301813. ISSN 1521-3773.
- ^ a b Breiten, Benjamin; Lockett, Matthew R.; Sherman, Woody; Fujita, Shuji; Al-sayah, Mohammad; Lange, Heiko; Bowers, Carleen M.; Heroux, Annie et al. (2013). “Water Networks Contribute to Enthalpy/Entropy Compensation in Protein–Ligand Binding”. Journal of the American Chemical Society 135 (41): 15579–15584. doi:10.1021/ja4075776.
- ^ Cosic, I (1994). “Macromolecular bioactivity: is it resonant interaction between macromolecules?—theory and applications”. IEEE transactions on bio-medical engineering 41 (12): 1101–14. doi:10.1109/10.335859. PMID 7851912.
- ^ Baron, Riccardo; Setny, Piotr; McCammon, J. Andrew (2010). “Water in Cavity-Ligand Recognition”. Journal of the American Chemical Society 132 (34): 12091–12097. doi:10.1021/ja1050082. PMC 2933114. PMID 20695475.
- ^ Baron, Riccardo; McCammon, J. Andrew (2013). “Molecular Recognition and Ligand Binding”. Annual Review of Physical Chemistry 64: 151–175. doi:10.1146/annurev-physchem-040412-110047. PMID 23473376.
- ^ Lehn, Jean-Marie (1995). Supramolecular Chemistry. Weinheim: Wiley-VCH. ISBN 978-3-527-29312-4. OCLC 315928178[要ページ番号]
- ^ Gellman, Samuel H. (1997). “Introduction: Molecular Recognition”. Chemical Reviews 97 (5): 1231–1232. doi:10.1021/cr970328j. PMID 11851448.
- ^ Zhang, Jingqing; Landry, Markita P.; Barone, Paul W.; Kim, Jong-Ho; Lin, Shangchao; Ulissi, Zachary W.; Lin, Dahua; Mu, Bin et al. (Dec 2013). “Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes”. Nature Nanotechnology 8 (12): 959–968. ISSN 1748-3387.
- ^ Shinkai, Seiji; Ikeda, Masato; Sugasaki, Atsushi; Takeuchi, Masayuki (2001). “Positive allosteric systems designed on dynamic supramolecular scaffolds: toward switching and amplification of guest affinity and selectivity”. Accounts of Chemical Research 34 (6): 494–503. doi:10.1021/ar000177y. PMID 11412086.
- ^ Grunenberg, Jorg (2011). “Complexity in molecular recognition”. Phys. Chem. Chem. Phys. 13 (21): 10136–10146. doi:10.1039/C1CP20097F.
- ^ Mobley, David L.; Dill, Ken A. (2016/02/26). “Binding of Small-Molecule Ligands to Proteins: “What You See” Is Not Always “What You Get””. Structure 17 (4): 489–498. doi:10.1016/j.str.2009.02.010. ISSN 0969-2126.
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