HIPK2
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/10/09 14:39 UTC 版)
HIPK2（homeodomain-interacting protein kinase 2）は、ヒトではHIPK2遺伝子にコードされる酵素である[5]。HIPK2はセリン/スレオニンキナーゼに分類され、ホメオドメイン型転写因子と相互作用する[6]。DYRKキナーゼと呼ばれるプロテインキナーゼのファミリーに属する[7]。このファミリー内では、HIPK2はHIPK1やHIPK3とともにHIPK（homeodomain-interacting protein kinase）グループに属する[8]。HIPK2はさまざまな生物種に広く存在し、その遺伝子発現やアポトーシスにおける機能はいくつかの異なる機構によって調節されている。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000064393 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061436 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Isolation and characterization of cDNAs for the protein kinase HIPK2”. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1518 (1–2): 168–72. (March 2001). doi:10.1016/S0167-4781(00)00308-0. PMID 11267674.
- ^ “Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation”. FEBS Letters 579 (14): 3001–8. (June 2005). doi:10.1016/j.febslet.2005.04.053. PMID 15896780.
- ^ a b c d “Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34”. Biochimie 82 (12): 1123–7. (2000). doi:10.1016/S0300-9084(00)01196-2. PMID 11120354.
- ^ a b c d e f g h i j k “Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors”. The Journal of Biological Chemistry 273 (40): 25875–9. (October 1998). doi:10.1074/jbc.273.40.25875. PMID 9748262.
- ^ “HIPK2 homeodomain interacting protein kinase 2 [Canis lupus familiaris (dog) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2017年11月29日閲覧。
- ^ “HIPK2 homeodomain interacting protein kinase 2 [Felis catus (domestic cat) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2017年11月29日閲覧。
- ^ “HIPK2 homeodomain interacting protein kinase 2 [Ovis aries (sheep) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2017年11月29日閲覧。
- ^ “hipk2 homeodomain interacting protein kinase 2 [Danio rerio (zebrafish) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2017年11月29日閲覧。
- ^ “The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues”. Biochemical and Biophysical Research Communications 290 (3): 942–7. (January 2002). doi:10.1006/bbrc.2001.6310. PMID 11798164.
- ^ “Isolation and characterization of cDNAs for the protein kinase HIPK2”. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1518 (1–2): 168–72. (2001). doi:10.1016/S0167-4781(00)00308-0. PMID 11267674. "The nucleotide sequence data have been deposited in GenBank under the accession numbers AF208291 and AF208292, respectively"
- ^ “Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1”. Proceedings of the National Academy of Sciences of the United States of America 96 (22): 12350–5. (October 1999). doi:10.1073/pnas.96.22.12350. PMC 22920. PMID 10535925.
- ^ “Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53”. Experimental Cell Research 317 (7): 1060–70. (April 2011). doi:10.1016/j.yexcr.2010.12.016. PMID 21192925.
- ^ a b c d e f g h i j k l m “How cells switch HIPK2 on and off”. Cell Death and Differentiation 16 (2): 187–94. (February 2009). doi:10.1038/cdd.2008.154. PMID 18974774.
- ^ “AceView: Gene:HIPK2, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.”. www.ncbi.nlm.nih.gov. 2021年2月4日閲覧。
- ^ “DYRK gene structure and erythroid-restricted features of DYRK3 gene expression”. Genomics 85 (1): 117–30. (January 2005). doi:10.1016/j.ygeno.2004.08.021. PMID 15607427.
- ^ “HIPK2 - Homeodomain-interacting protein kinase 2 - Homo sapiens (Human) - HIPK2 gene & protein”. www.uniprot.org. 2017年11月28日閲覧。
- ^ a b “ExPASy - ProtParam”. web.expasy.org. 2017年11月28日閲覧。
- ^ “Characterization of Human Homeodomain-interacting Protein Kinase 4 (HIPK4) as a Unique Member of the HIPK Family”. Molecular and Cellular Pharmacology 2 (2): 61–68. (2010). PMC 2876313. PMID 20508833.
- ^ a b “Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies”. Oncotarget 8 (12): 20452–20461. (March 2017). doi:10.18632/oncotarget.14723. PMC 5386776. PMID 28107201.
- ^ a b “Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome”. International Journal of Molecular Sciences 17 (10): 1638. (September 2016). doi:10.3390/ijms17101638. PMC 5085671. PMID 27689990.
- ^ a b “Control of nuclear HIPK2 localization and function by a SUMO interaction motif”. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813 (2): 283–97. (February 2011). doi:10.1016/j.bbamcr.2010.11.022. PMID 21145359.
- ^ “Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo”. The Journal of Biological Chemistry 277 (35): 32020–8. (August 2002). doi:10.1074/jbc.M200153200. PMID 11925430.
- ^ a b c d e “Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells”. Oncogene 29 (31): 4378–87. (August 2010). doi:10.1038/onc.2010.183. PMID 20514025.
- ^ “Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc”. Experimental Cell Research 315 (1): 67–75. (January 2009). doi:10.1016/j.yexcr.2008.10.018. PMID 18996371.
- ^ a b “Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP”. Cell 115 (2): 177–86. (October 2003). doi:10.1016/S0092-8674(03)00802-X. PMID 14567915.
- ^ a b c d “A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress”. Molecular Cell 46 (4): 472–83. (May 2012). doi:10.1016/j.molcel.2012.03.003. PMID 22503103.
- ^ a b c “Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR”. Nature Cell Biology 10 (7): 812–24. (July 2008). doi:10.1038/ncb1743. PMID 18536714.
- ^ a b c “p300-mediated acetylation increased the protein stability of HIPK2 and enhanced its tumor suppressor function”. Scientific Reports 7 (1): 16136. (November 2017). doi:10.1038/s41598-017-16489-w. PMC 5701035. PMID 29170424.
- ^ a b c “HIPK2 modification code for cell death and survival”. Molecular & Cellular Oncology 1 (2): e955999. (2014-10-29). doi:10.1080/23723548.2014.955999. PMC 4905192. PMID 27308327.
- ^ a b “MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis”. Molecular Cell 25 (5): 739–50. (March 2007). doi:10.1016/j.molcel.2007.02.008. PMID 17349959.
- ^ a b “Apoptotic threshold is lowered by p53 transactivation of caspase-6”. Proceedings of the National Academy of Sciences of the United States of America 99 (14): 9492–7. (July 2002). doi:10.1073/pnas.132241599. PMC 123168. PMID 12089322.
- ^ a b c d e f “Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription”. Oncogene 26 (51): 7231–9. (November 2007). doi:10.1038/sj.onc.1210523. PMID 17533375.
- ^ “Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival”. PLOS ONE 5 (4): e10171. (April 2010). doi:10.1371/journal.pone.0010171. PMC 2854690. PMID 20418953.
- ^ “Role of HIPK2 in kidney fibrosis”. Kidney International Supplements 4 (1): 97–101. (November 2014). doi:10.1038/kisup.2014.18. PMC 4536960. PMID 26312158.
- ^ Guo, Yuanjun; Sui, Jennifer; Zhang, Qinkun; Barnett, Joey; Force, Thomas; Lal, Hind (2017-11-14). “Abstract 18728: Loss of Homeodomain-Interacting Protein Kinase 2 in Cardiomyocytes Leads to Cardiac Dysfunction”. Circulation 136 (Suppl 1): A18728. ISSN 0009-7322.
- ^ “Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2”. Cellular Signalling 27 (11): 2252–60. (November 2015). doi:10.1016/j.cellsig.2015.08.001. PMID 26247811.
- ^ “Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation”. The Journal of Biological Chemistry 278 (40): 38998–9005. (October 2003). doi:10.1074/jbc.M307112200. PMID 12874272.
- ^ “TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity”. The Journal of Biological Chemistry 278 (39): 37722–9. (September 2003). doi:10.1074/jbc.M301979200. PMID 12851404.
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