シクロール仮説
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/11/05 20:39 UTC 版)
シクロール仮説(シクロールかせつ、英: cyclol hypothesis)は、折り畳まれた球状タンパク質の初の構造モデルである[1]。1930年代末にドロシー・リンチによって構築された本仮説は3つの仮定に基づいている。まずはじめに、本仮説は、2つのペプチド結合がシクロール反応(図1)によって架橋されうることを仮定する。これらの架橋はペプチド基間の「非共有結合性」水素結合の共有結合版である。これらの反応はエルゴペプチド類やその他の化合物において観察される。次に、ある条件下において、アミノ酸が自然に可能な最大の数のシクロール架橋を作り、シクロール分子(図2)およびシクロール生地(cyclol fabrics; 図3)が生じることを仮定する。これらのシクロール分子およびシクロール生地はこれまで観察されたことはない。最後に、本仮説は、球状タンパク質が自由端を持たないシクロール生地から形成されるプラトン立体および半正多面体に対応する三次構造を持つことを仮定する。こういった「閉シクロール」分子についても観察されたことはない。
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