インスリン様成長因子1受容体
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/10/04 05:27 UTC 版)
インスリン様成長因子1受容体（インスリンようせいちょういんし1じゅようたい、英: insulin-like growth factor 1 receptor、略称: IGF-1受容体、IGF-1R）は、細胞の表面に存在するタンパク質である。受容体型チロシンキナーゼに分類される膜貫通受容体で、インスリン様成長因子1（IGF-1）とインスリン様成長因子2（IGF-2）と呼ばれるホルモンによって活性化される。IGF-1はインスリンに似た分子構造を持つペプチドホルモンで、成長に重要な役割を果たす。IGF-1受容体を欠失したマウスは発生後期に死亡するが、体重の劇的な低下がみられることからも、この受容体の強力な成長促進効果が示されている。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140443 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005533 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “The IGF axis in the development and progression of prostate cancer”. Recent Research Developments in Cancer: 437–462. (2001). ISBN 81-7895-002-2.
- ^ a b Hakuno, Fumihiko; Takahashi, Shin-Ichiro (07 2018). “IGF1 receptor signaling pathways”. Journal of Molecular Endocrinology 61 (1): T69–T86. doi:10.1530/JME-17-0311. ISSN 1479-6813. PMID 29535161.
- ^ “Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases”. Science Signaling 8 (405): rs13. (December 2015). doi:10.1126/scisignal.aaa6711. PMC 4766099. PMID 26628682.
- ^ “Insulin-like growth factors and their binding proteins: biological actions”. Endocrine Reviews 16 (1): 3–34. (February 1995). doi:10.1210/edrv-16-1-3. PMID 7758431.
- ^ “Molecular and cellular aspects of the insulin-like growth factor I receptor”. Endocrine Reviews 16 (2): 143–63. (April 1995). doi:10.1210/edrv-16-2-143. PMID 7540132.
- ^ Mohammed, Rabeea Hazim; Anderton, Helen; Brameld, John Michael; Sweetman, Dylan (2017). “Effects of insulin like growth factors on early embryonic chick limb myogenesis”. PloS One 12 (10): e0185775. doi:10.1371/journal.pone.0185775. ISSN 1932-6203. PMC 5626492. PMID 28972999.
- ^ Rowzee, Anne M.; Lazzarino, Deborah A.; Rota, Lauren; Sun, Zhaoyu; Wood, Teresa L. (2008-12). “IGF ligand and receptor regulation of mammary development”. Journal of Mammary Gland Biology and Neoplasia 13 (4): 361–370. doi:10.1007/s10911-008-9102-8. ISSN 1573-7039. PMC 2665296. PMID 19020961.
- ^ Kooijman, Ron (2006-08). “Regulation of apoptosis by insulin-like growth factor (IGF)-I”. Cytokine & Growth Factor Reviews 17 (4): 305–323. doi:10.1016/j.cytogfr.2006.02.002. ISSN 1359-6101. PMID 16621671.
- ^ “Insulin-like growth factor - oestradiol crosstalk and mammary gland tumourigenesis”. Biochimica et Biophysica Acta 1836 (2): 345–53. (December 2013). doi:10.1016/j.bbcan.2013.10.005. PMID 24189571.
- ^ “Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice”. International Journal of Developmental Neuroscience 25 (1): 23–8. (February 2007). doi:10.1016/j.ijdevneu.2006.11.004. PMID 17194562.
- ^ “Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice”. International Journal of Developmental Neuroscience 24 (7): 431–6. (November 2006). doi:10.1016/j.ijdevneu.2006.08.008. PMID 17034982.
- ^ “IGF1R variants associated with isolated single suture craniosynostosis”. American Journal of Medical Genetics. Part A 155A (1): 91–7. (January 2011). doi:10.1002/ajmg.a.33781. PMC 3059230. PMID 21204214.
- ^ a b “The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs”. Mammalian Genome 23 (11–12): 780–90. (December 2012). doi:10.1007/s00335-012-9417-z. PMC 3511640. PMID 22903739.
- ^ Diseases of the Breast. Lippincott Williams & Wilkins. (28 March 2012). pp. 88–. ISBN 978-1-4511-4870-1
- ^ “Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease”. Cancer Research 62 (10): 2942–50. (May 2002). PMID 12019176.
- ^ “Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model”. Cancer Research 64 (23): 8620–9. (December 2004). doi:10.1158/0008-5472.CAN-04-2446. PMID 15574769.
- ^ “RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility”. Oncogene 25 (16): 2285–96. (April 2006). doi:10.1038/sj.onc.1209260. PMID 16314838.
- ^ “Insulin receptor is expressed in normal canine mammary gland and benign adenomas but decreased in metastatic canine mammary carcinomas similar to human breast cancer”. Veterinary and Comparative Oncology 8 (4): 293–301. (December 2010). doi:10.1111/j.1476-5829.2009.00232.x. PMID 21062411.
- ^ “Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles”. BMC Cancer 10: 618. (November 2010). doi:10.1186/1471-2407-10-618. PMC 2994823. PMID 21062462.
- ^ “Identification of druggable cancer driver genes amplified across TCGA datasets”. PLOS ONE 9 (5): e98293. (2014). Bibcode: 2014PLoSO...998293C. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
- ^ “Substrate competitive inhibitors of IGF-1 receptor kinase”. Biochemistry 39 (51): 15705–12. (December 2000). doi:10.1021/bi001516y. PMID 11123895.
- ^ García-Echeverría, Carlos; Pearson, Mark A.; Marti, Andreas; Meyer, Thomas; Mestan, Juergen; Zimmermann, Johann; Gao, Jiaping; Brueggen, Josef et al. (2004-03). “In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase”. Cancer Cell 5 (3): 231–239. doi:10.1016/s1535-6108(04)00051-0. ISSN 1535-6108. PMID 15050915.
- ^ “Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF”. The Journal of Cell Biology 155 (5): 809–20. (November 2001). doi:10.1083/jcb.200106139. PMC 2150867. PMID 11724822.
- ^ “C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor”. The Journal of Biological Chemistry 274 (9): 5422–8. (February 1999). doi:10.1074/jbc.274.9.5422. PMID 10026153.
- ^ a b c “Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis”. Cancer Research 68 (14): 5669–77. (July 2008). doi:10.1158/0008-5472.CAN-07-6364. PMID 18632619.
- ^ “Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29”. The Journal of Biological Chemistry 276 (35): 33054–60. (August 2001). doi:10.1074/jbc.M009913200. PMID 11423532.
- ^ a b “The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor”. Molecular and Cellular Biology 23 (9): 3363–72. (May 2003). doi:10.1128/mcb.23.9.3363-3372.2003. PMC 153198. PMID 12697834.
- ^ a b c “Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10”. Molecular Endocrinology 10 (6): 631–41. (June 1996). doi:10.1210/mend.10.6.8776723. PMID 8776723.
- ^ “Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. The Journal of Biological Chemistry 273 (12): 6860–7. (March 1998). doi:10.1074/jbc.273.12.6860. PMID 9506989.
- ^ “Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Research 56 (14): 3165–7. (July 1996). PMID 8764099.
- ^ a b “Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility”. Molecular and Cellular Biology 19 (4): 3125–35. (April 1999). doi:10.1128/mcb.19.4.3125. PMC 84106. PMID 10082579.
- ^ a b “Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system”. The Journal of Biological Chemistry 270 (40): 23456–60. (October 1995). doi:10.1074/jbc.270.40.23456. PMID 7559507.
- ^ “Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins”. Molecular Endocrinology 11 (13): 1911–23. (December 1997). doi:10.1210/mend.11.13.0029. PMID 9415396.
- ^ a b “Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein”. The Journal of Biological Chemistry 270 (32): 19151–7. (August 1995). doi:10.1074/jbc.270.32.19151. PMID 7642582.
- ^ “Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity”. Endocrine-Related Cancer. 12 12 Suppl 1: S61-73. (July 2005). doi:10.1677/erc.1.01018. PMID 16113100.
- ^ “Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor”. The Journal of Biological Chemistry 273 (37): 24095–101. (September 1998). doi:10.1074/jbc.273.37.24095. PMID 9727029.
- ^ “Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor”. Biochemical and Biophysical Research Communications 278 (1): 38–43. (November 2000). doi:10.1006/bbrc.2000.3762. PMID 11071852.
- ^ “14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner”. The Journal of Biological Chemistry 272 (17): 11663–9. (April 1997). doi:10.1074/jbc.272.17.11663. PMID 9111084.
- ^ “MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells”. The Biochemical Journal 432 (1): 199–205. (November 2010). doi:10.1042/BJ20100859. PMC 3130335. PMID 20819078.
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