Hsp70
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/02/29 15:55 UTC 版)
Hsp70（70 kDa heat shock protein）ファミリーまたはDnaKファミリーは、普遍的に発現している保存された熱ショックタンパク質のファミリーである。類似した構造を持つタンパク質は事実上すべての生物に存在する。Hsp70はタンパク質のフォールディング装置の重要な部分をなし、ストレスからの細胞の保護を助けている[2][3]。
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- ^ a b “Hsp70 in cancer: A double agent in the battle between survival and death”. Journal of Cellular Physiology. (November 2020). doi:10.1002/jcp.30132. PMID 33169384.
- ^ a b “GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: nucleotide exchange factors for Hsp70 molecular chaperones”. Sub-Cellular Biochemistry. Subcellular Biochemistry 78: 1–33. (2015). doi:10.1007/978-3-319-11731-7_1. ISBN 978-3-319-11730-0. PMID 25487014.
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- ^ “The level and phosphorylation of Hsp70 in the rat liver cytosol after adrenalectomy and hyperthermia”. Cell Biology International 23 (4): 313–20. (1999-04-01). doi:10.1006/cbir.1998.0247. PMID 10600240.
- ^ “The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C”. The Journal of Biological Chemistry 277 (35): 31585–92. (August 2002). doi:10.1074/jbc.M204335200. PMID 12080070.
- ^ “CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression” (英語). Cell 151 (6): 1308–18. (December 2012). doi:10.1016/j.cell.2012.10.051. PMC 3778871. PMID 23217712.
- ^ “C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances”. Oncogene 32 (25): 3101–10. (June 2013). doi:10.1038/onc.2012.314. PMID 22824801.
- ^ “The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome”. The Journal of Biological Chemistry 275 (7): 4613–7. (February 2000). doi:10.1074/jbc.275.7.4613. PMID 10671488.
- ^ “Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome”. Nature Cell Biology 2 (8): 469–75. (August 2000). doi:10.1038/35019501. PMID 10934466.
- ^ “HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction”. PLoS Biology 8 (7): e1000410. (July 2010). doi:10.1371/journal.pbio.1000410. PMC 2897763. PMID 20625543.
- ^ “Long-term prognostic significance of HSP-70, c-myc and HLA-DR expression in patients with malignant melanoma”. European Journal of Surgical Oncology 27 (1): 88–93. (February 2001). doi:10.1053/ejso.1999.1018. PMID 11237497.
- ^ “Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis”. Histology and Histopathology 22 (10): 1099–107. (October 2007). doi:10.14670/HH-22.1099. PMID 17616937.
- ^ “Heat shock proteins in cancer”. Annals of the New York Academy of Sciences 1113 (1): 192–201. (October 2007). Bibcode: 2007NYASA1113..192S. doi:10.1196/annals.1391.030. PMID 17978282.
- ^ “Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction”. PLOS One 11 (8): e0160312. (2016). doi:10.1371/journal.pone.0160312. PMID 27483141.
- ^ “Expression of heat shock proteins 70 and 47 in tissues following short-pulse laser irradiation: assessment of thermal damage and healing”. Medical Engineering & Physics 35 (10): 1406–14. (October 2013). doi:10.1016/j.medengphy.2013.03.011. PMID 23587755.
- ^ “Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli”. Biochemical and Biophysical Research Communications 293 (5): 1389–95. (May 2002). doi:10.1016/S0006-291X(02)00403-5. PMID 12054669.
- ^ a b “Guidelines for the nomenclature of the human heat shock proteins”. Cell Stress & Chaperones 14 (1): 105–11. (January 2009). doi:10.1007/s12192-008-0068-7. PMC 2673902. PMID 18663603.
[続きの解説]
「Hsp70」の続きの解説一覧
- 1 Hsp70とは
- 2 Hsp70の概要
- 3 がん
- 4 外部リンク
- HSP70のページへのリンク
