G1サイクリン
同義/類義語：G1-サイクリン, サイクリンD
英訳・(英)同義/類義語：G_1 cyclin, G1-cyclin
細胞周期を制御するサイクリンの一種で、G1期に発現して特定のサイクリン依存タンパクキナーゼと結合して、これを活性化し、開始点を通過させる。
英訳・(英)同義/類義語：G_1 cyclin, G1-cyclin
細胞周期を制御するサイクリンの一種で、G1期に発現して特定のサイクリン依存タンパクキナーゼと結合して、これを活性化し、開始点を通過させる。
「生物学用語辞典」の他の用語
| 酵素タンパク質モチーフなど： | Fアクチン F型ATPアーゼ G1/S-サイクリン G1サイクリン Gアクチン Gタンパク質 Gタンパク質αサブユニット |
サイクリンD
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/05/07 07:48 UTC 版)
サイクリンD（英: cyclin D）は、細胞周期の進行を調節するサイクリンファミリーのメンバーである。サイクリンDの合成はG1期に開始され、G1期からS期への移行を駆動する。サイクリンDタンパク質は生物種によって、155アミノ酸（カワホトトギスガイ）から477アミノ酸（ショウジョウバエ）とさまざまである[2]。
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- ^ “Growth control by intracellular tension and extracellular stiffness”. Trends Cell Biol. 18 (7): 347–52. (July 2008). doi:10.1016/j.tcb.2008.05.002. PMC 2888483. PMID 18514521.
- ^ “The p21Cip1 and p27Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts”. The EMBO Journal 18 (6): 1571–1583. (March 1999). doi:10.1093/emboj/18.6.1571. PMC 1171245. PMID 10075928.
- ^ “Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels.”. J Biol Chem 270 (36): 21176–21180. (September 1995). doi:10.1074/jbc.270.36.21176. PMID 7673150.
- ^ “eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR”. J Biol Chem 169 (2): 245–256. (April 2005). doi:10.1083/jcb.200501019. PMC 2171863. PMID 15837800.
- ^ “Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization”. Genes Dev 12 (22): 3499–3511. (November 1998). doi:10.1101/gad.12.22.3499. PMC 317244. PMID 9832503.
- ^ “GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy”. Cell. Signal. 20 (4): 581–9. (April 2008). doi:10.1016/j.cellsig.2007.10.018. PMID 18023328.
- ^ “Multiple levels of cyclin specificity in cell-cycle control”. Nat. Rev. Mol. Cell Biol. 8 (2): 149–60. (February 2007). doi:10.1038/nrm2105. PMID 17245415.
- ^ a b Lee, RJ; Albanese, C; Fu, M; D'Amico, M; Lin, B; Watanabe, G; Haines GK, 3rd; Siegel, PM et al. (January 2000). “Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.”. Molecular and Cellular Biology 20 (2): 672–83. doi:10.1128/mcb.20.2.672-683.2000. PMC 85165. PMID 10611246.
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- ^ Hulit, J; Wang, C; Li, Z; Albanese, C; Rao, M; Di Vizio, D; Shah, S; Byers, SW et al. (September 2004). “Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.”. Molecular and Cellular Biology 24 (17): 7598–611. doi:10.1128/MCB.24.17.7598-7611.2004. PMC 507010. PMID 15314168.
- ^ Wang, TC; Cardiff, RD; Zukerberg, L; Lees, E; Arnold, A; Schmidt, EV (23 June 1994). “Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice.”. Nature 369 (6482): 669–71. doi:10.1038/369669a0. PMID 8208295.
- ^ Albanese, C; D'Amico, M; Reutens, AT; Fu, M; Watanabe, G; Lee, RJ; Kitsis, RN; Henglein, B et al. (26 November 1999). “Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.”. The Journal of Biological Chemistry 274 (48): 34186–95. doi:10.1074/jbc.274.48.34186. PMID 10567390.
- ^ Casimiro, MC; Crosariol, M; Loro, E; Ertel, A; Yu, Z; Dampier, W; Saria, EA; Papanikolaou, A et al. (March 2012). “ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice.”. The Journal of Clinical Investigation 122 (3): 833–43. doi:10.1172/JCI60256. PMC 3287228. PMID 22307325.
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- ^ Casimiro, MC; Di Sante, G; Di Rocco, A; Loro, E; Pupo, C; Pestell, T; Bisetto, S; Velasco-Velàzquez, MA et al. (18 May 2017). “Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis.”. Cancer Research 77 (13): 3391–3405. doi:10.1158/0008-5472.CAN-16-0425. PMC 5705201. PMID 28522753.
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- ^ Lee, RJ; Albanese, C; Stenger, RJ; Watanabe, G; Inghirami, G; Haines GK, 3rd; Webster, M; Muller, WJ et al. (12 March 1999). “pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells.”. The Journal of Biological Chemistry 274 (11): 7341–50. doi:10.1074/jbc.274.11.7341. PMID 10066798.
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- ^ Matsumura, I; Kitamura, T; Wakao, H; Tanaka, H; Hashimoto, K; Albanese, C; Downward, J; Pestell, RG et al. (1 March 1999). “Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells.”. The EMBO Journal 18 (5): 1367–77. doi:10.1093/emboj/18.5.1367. PMC 1171226. PMID 10064602.
- ^ Molecular cell biology. New York: Scientific American Books. (1999). ISBN 978-0-7167-3136-8
- ^ D.H. Sanes; T.A. Reh; W.A. Harris (2005). Development of the Nervous System (2 ed.). Elsevier Ltd, Oxford. ISBN 978-0126186215
- ^ “Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice”. Proc. Natl. Acad. Sci. U.S.A. 98 (1): 194–9. (January 2001). doi:10.1073/pnas.011522998. PMC 14567. PMID 11134518.
[続きの解説]
「サイクリンD」の続きの解説一覧
- 1 サイクリンDとは
- 2 サイクリンDの概要
- 3 機能
- 4 変異体の表現型
- サイクリンDのページへのリンク
