HLA-F
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/03/27 08:42 UTC 版)
HLA-F（HLA class I histocompatibility antigen, alpha chain F）は、ヒトではHLA-F遺伝子にコードされるタンパク質である[5][6]。HLA-Fは膜に固定された非古典的MHCクラスI分子であり、主に細胞内に位置してβ2-ミクログロブリンとヘテロ二量体を形成している。HLA-Fは小胞体とゴルジ体に局在し、他のHLA遺伝子と比較してヒト集団における多型は少ない。一方で、HLA-F遺伝子には多数の転写バリアントに由来するさまざまなアイソフォームが見つかっている。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000229698、ENSG00000237508、ENSG00000234487、ENSG00000206509、ENSG00000137403、ENSG00000235220、ENSG00000204642 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079492 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c d e “Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element”. The Journal of Experimental Medicine 171 (1): 1–18. (January 1990). doi:10.1084/jem.171.1.1. PMC 2187653. PMID 1688605.
- ^ a b “Entrez Gene: HLA-F major histocompatibility complex, class I, F”. 2023年2月11日閲覧。
- ^ Krebs, J.E.; Goldstein, E.S.; Kilpatrick, S.T. (2014). “Chapter 18: Somatic recombination and hypermutation in the immune system”. Lewin's GENES XI. USA: Jones & Bartlett Learning. pp. 459–99. ISBN 978-1-4496-5985-1
- ^ a b c d “HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes”. Immunogenetics 58 (4): 241–251. (May 2006). doi:10.1007/s00251-005-0076-z. PMID 16570139.
- ^ “Toward understanding MHC disease associations: partial resequencing of 46 distinct HLA haplotypes”. Genomics 87 (5): 561–571. (May 2006). doi:10.1016/j.ygeno.2005.11.020. PMID 16434165.
- ^ a b “Chromosomal organization of the human major histocompatibility complex class I gene family”. The Journal of Experimental Medicine 169 (2): 469–480. (February 1989). doi:10.1084/jem.169.2.469. PMC 2189218. PMID 2562983.
- ^ “A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment”. Proceedings of the National Academy of Sciences of the United States of America 84 (24): 9145–9149. (December 1987). Bibcode: 1987PNAS...84.9145G. doi:10.1073/pnas.84.24.9145. PMC 299709. PMID 3480534.
- ^ “Genetic divergence of the rhesus macaque major histocompatibility complex”. Genome Research 14 (8): 1501–1515. (August 2004). doi:10.1101/gr.2134504. PMC 509259. PMID 15289473.
- ^ a b c d “HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern”. Journal of Immunology 164 (1): 319–328. (January 2000). doi:10.4049/jimmunol.164.1.319. PMID 10605026.
- ^ “Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-G”. Immunological Reviews 163: 129–138. (June 1998). doi:10.1111/j.1600-065x.1998.tb01192.x. PMID 9700506.
- ^ a b c “Selective export of HLA-F by its cytoplasmic tail”. Journal of Immunology 176 (11): 6464–6472. (June 2006). doi:10.4049/jimmunol.176.11.6464. PMID 16709803.
- ^ a b c d “HLA-F complex without peptide binds to MHC class I protein in the open conformer form”. Journal of Immunology 184 (11): 6199–6208. (June 2010). doi:10.4049/jimmunol.1000078. PMC 3777411. PMID 20483783.
- ^ a b “HLA-F: A New Kid Licensed for Peptide Presentation” (English). Immunity 46 (6): 972–974. (June 2017). doi:10.1016/j.immuni.2017.06.004. PMID 28636965.
- ^ a b c d “Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1”. Nature Immunology 17 (9): 1067–1074. (September 2016). doi:10.1038/ni.3513. PMC 4992421. PMID 27455421.
- ^ a b c d e “HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway”. Journal of Immunology 191 (4): 1567–1577. (August 2013). doi:10.4049/jimmunol.1300080. PMC 3732835. PMID 23851683.
- ^ a b c “HLA-F surface expression on B cell and monocyte cell lines is partially independent from tapasin and completely independent from TAP”. Journal of Immunology 171 (10): 5264–5271. (November 2003). doi:10.4049/jimmunol.171.10.5264. PMID 14607927.
- ^ a b c “Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors”. European Journal of Immunology 30 (12): 3552–3561. (December 2000). doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396.
- ^ a b c d “HLA-F is a surface marker on activated lymphocytes”. European Journal of Immunology 40 (8): 2308–2318. (August 2010). doi:10.1002/eji.201040348. PMC 3867582. PMID 20865824.
- ^ a b c “Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition”. Journal of Immunology 171 (3): 1376–1384. (August 2003). doi:10.4049/jimmunol.171.3.1376. PMID 12874228.
- ^ a b Allen, Rachel Louise, ed (2016-09-20). “HLA-F and MHC-I Open Conformers Bind Natural Killer Cell Ig-Like Receptor KIR3DS1”. PLOS ONE 11 (9): e0163297. Bibcode: 2016PLoSO..1163297B. doi:10.1371/journal.pone.0163297. PMC 5029895. PMID 27649529.
- ^ “HLA-H: Transcriptional Activity and HLA-E Mobilization”. Frontiers in Immunology 10: 2986. (2020). doi:10.3389/fimmu.2019.02986. PMC 6978722. PMID 32010122.
- ^ “A role for both HLA-F and HLA-G in reproduction and during pregnancy?”. Human Immunology. HLA-G Special Issue 81 (4): 127–133. (April 2020). doi:10.1016/j.humimm.2019.09.006. PMID 31558330.
- ^ “Tetrameric complexes of HLA-E, HLA-F, and HLA-G”. Journal of Immunological Methods 268 (1): 43–50. (October 2002). doi:10.1016/s0022-1759(02)00199-0. PMID 12213342.
- ^ a b “HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors”. Journal of Immunology 191 (7): 3553–3562. (October 2013). doi:10.4049/jimmunol.1300081. PMC 3780715. PMID 24018270.
- ^ a b “HLA-F and MHC-I Open Conformers Bind Natural Killer Cell Ig-Like Receptor KIR3DS1”. PLOS ONE 11 (9): e0163297. (2016-09-20). Bibcode: 2016PLoSO..1163297B. doi:10.1371/journal.pone.0163297. PMC 5029895. PMID 27649529.
- ^ “Human leukocyte antigen (HLA)-E and HLA-F expression in gastric cancer”. Anticancer Research 35 (4): 2279–2285. (April 2015). PMID 25862890.
- ^ “Clinical implication of human leukocyte antigen (HLA)-F expression in breast cancer”. Pathology International 65 (11): 569–574. (November 2015). doi:10.1111/pin.12343. PMID 26332651.
- ^ “Alteration of HLA-F and HLA I antigen expression in the tumor is associated with survival in patients with esophageal squamous cell carcinoma”. International Journal of Cancer 132 (1): 82–89. (January 2013). doi:10.1002/ijc.27621. PMID 22544725.
- ^ “HLA-F expression is a prognostic factor in patients with non-small-cell lung cancer”. Lung Cancer 74 (3): 504–509. (December 2011). doi:10.1016/j.lungcan.2011.04.006. PMID 21561677.
- ^ “Lesion human leukocyte antigen-F expression is associated with a poor prognosis in patients with hepatocellular carcinoma”. Oncology Letters 9 (1): 300–304. (January 2015). doi:10.3892/ol.2014.2686. PMC 4246689. PMID 25435979.
- ^ “Plasma levels of soluble HLA-E and HLA-F at diagnosis may predict overall survival of neuroblastoma patients”. BioMed Research International 2013: 956878. (2013-11-21). doi:10.1155/2013/956878. PMC 3856218. PMID 24350297.
- ^ “Non-classical MHC-Ι genes in chronic hepatitis B and hepatocellular carcinoma”. Immunogenetics 64 (3): 251–258. (March 2012). doi:10.1007/s00251-011-0580-2. PMID 22015712.
- ^ “Serum antibodies to human leucocyte antigen (HLA)-E, HLA-F and HLA-G in patients with systemic lupus erythematosus (SLE) during disease flares: Clinical relevance of HLA-F autoantibodies”. Clinical and Experimental Immunology 183 (3): 326–340. (March 2016). doi:10.1111/cei.12724. PMC 4750595. PMID 26440212.
- ^ “Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes”. Diabetologia 59 (11): 2448–2458. (November 2016). doi:10.1007/s00125-016-4067-4. PMC 5042874. PMID 27506584.
[続きの解説]
「HLA-F」の続きの解説一覧
- 1 HLA-Fとは
- 2 HLA-Fの概要
- 3 HLA-F
- 4 発現
- 5 転写調節
- 6 関連文献
- hlafのページへのリンク
