Dicer
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/08/11 23:43 UTC 版)
Dicerは、ヒトではDICER1遺伝子によってコードされる酵素である。DicerはRNase IIIファミリーに属し、二本鎖RNA（dsRNA）とpre-miRNAをそれぞれsiRNA、miRNAと呼ばれる短いdsRNA断片へと切断する。これらの断片は約20–25塩基対の長さであり、3'末端に2塩基のオーバーハングが存在する。DicerはRNAiに必要不可欠なRNA誘導サイレンシング複合体（RISC）の活性化を促進する。RISCは触媒を担う構成要素としてArgonauteを持ち、ArgonauteはmRNAを分解するエンドヌクレアーゼである。
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[続きの解説]
「Dicer」の続きの解説一覧
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