DNAワクチン接種
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/04/30 10:15 UTC 版)
DNAワクチン接種（DNAワクチンせっしゅ）あるいはDNAワクチン投与（DNAワクチンとうよ）は、特定の抗原のDNAコード配列を免疫化された種の細胞にトランスフェクトする技術である[1][2]。
- ^ Developing Snake antivenom sera by genetic immunization
- ^ DNA immunization as a technology platform for monoclonal antibody induction
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- ^ US Patent 4722848 - Method for immunizing animals with synthetically modified vaccinia virus
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- ^ “Fort Dodge Animal Health Announces Approval of West Nile Virus DNA Vaccine for Horses”. PR Newswire. (2005年7月18日). オリジナルの2011年5月16日時点におけるアーカイブ。 2007年11月21日閲覧。
- ^ “CDC and Fort Dodge Animal Health Achieve First Licensed DNA Vaccine”. CDC. (2005年7月18日). オリジナルの2007年8月20日時点におけるアーカイブ。 2007年11月21日閲覧。
- ^ Developing Snake antivenom sera by genetic immunization
- ^ DNA immunization as a technology platform for monoclonal antibody induction
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- ^ Harmon, B. T.; Aly, A. E.; Padegimas, L.; Sesenoglu-Laird, O.; Cooper, M. J.; Waszczak, B. L. (2014). “Intranasal administration of plasmid DNA nanoparticles yields successful transfection and expression of a reporter protein in rat brain”. Gene Therapy 21 (5): 514–521. doi:10.1038/gt.2014.28. PMID 24670994.
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- ^ “Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage”. Journal of Virology 72 (2): 1497–503. (February 1998). doi:10.1128/JVI.72.2.1497-1503.1998. PMC 124631. PMID 9445053.
- ^ “Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo”. Virology 314 (1): 134–46. (September 2003). doi:10.1016/S0042-6822(03)00459-8. PMID 14517067.
- ^ “Structural instability of plasmid biopharmaceuticals: challenges and implications”. Trends in Biotechnology 27 (9): 503–11. (September 2009). doi:10.1016/j.tibtech.2009.06.004. PMID 19656584.
- ^ “Marker-free plasmids for biotechnological applications - implications and perspectives”. Trends in Biotechnology 31 (9): 539–47. (September 2013). doi:10.1016/j.tibtech.2013.06.001. PMID 23830144.
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- ^ “DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction”. Journal of Virology 71 (11): 8497–503. (November 1997). doi:10.1128/JVI.71.11.8497-8503.1997. PMC 192313. PMID 9343207.
- ^ a b “Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization”. The Journal of Experimental Medicine 185 (5): 909–20. (March 1997). doi:10.1084/jem.185.5.909. PMC 2196169. PMID 9120397.
- ^ “A rationally designed tyrosine hydroxylase DNA vaccine induces specific antineuroblastoma immunity”. Molecular Cancer Therapeutics 7 (7): 2241–51. (July 2008). doi:10.1158/1535-7163.MCT-08-0109. PMID 18645033.
- ^ a b “Genetic immunization of BALB/c mice with a plasmid bearing the gene coding for a hybrid merozoite surface protein 1-hepatitis B virus surface protein fusion protects mice against lethal Plasmodium chabaudi chabaudi PC1 infection”. Infection and Immunity 68 (10): 5839–45. (October 2000). doi:10.1128/IAI.68.10.5839-5845.2000. PMC 101545. PMID 10992493.
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- ^ “Increased DNA vaccine delivery and immunogenicity by electroporation in vivo”. Journal of Immunology 164 (9): 4635–40. (May 2000). doi:10.4049/jimmunol.164.9.4635. PMID 10779767.
- ^ a b “Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10”. Journal of Immunology 159 (4): 1945–52. (August 1997). PMID 9257860.
- ^ a b “Induction of CD8+ T cell responses to dominant and subdominant epitopes and protective immunity to Sendai virus infection by DNA vaccination”. Journal of Immunology 160 (5): 2425–32. (March 1998). PMID 9498786.
- ^ “DNA minigene vaccination for adjuvant neuroblastoma therapy”. Annals of the New York Academy of Sciences 1028 (1): 113–21. (December 2004). Bibcode: 2004NYASA1028..113L. doi:10.1196/annals.1322.012. PMID 15650237.
- ^ “Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization”. Science 270 (5234): 299–302. (October 1995). Bibcode: 1995Sci...270..299S. doi:10.1126/science.270.5234.299. PMID 7569980.
- ^ Nealon, Cory (2014年11月25日). “A hybrid vehicle that delivers DNA”. The State University of New York at Buffalo. 2014年12月16日閲覧。
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- ^ a b c d e “Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization”. Journal of Immunology 158 (5): 2278–84. (March 1997). PMID 9036975.
- ^ a b c d “Role of different lymphoid tissues in the initiation and maintenance of DNA-raised antibody responses to the influenza virus H1 glycoprotein”. Journal of Virology 70 (12): 9074–8. (December 1996). doi:10.1128/JVI.70.12.9074-9078.1996. PMC 191015. PMID 8971047.
- ^ “Characterization of humoral and CD4+ cellular responses after genetic immunization with retroviral vectors expressing different forms of the hepatitis B virus core and e antigens”. Journal of Virology 71 (7): 5295–303. (July 1997). doi:10.1128/JVI.71.7.5295-5303.1997. PMC 191766. PMID 9188598.
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- ^ a b “Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA”. Journal of Immunology 161 (6): 3042–9. (September 1998). PMID 9743369.
- ^ a b “Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization”. Proceedings of the National Academy of Sciences of the United States of America 93 (10): 5141–5. (May 1996). Bibcode: 1996PNAS...93.5141R. doi:10.1073/pnas.93.10.5141. PMC 39421. PMID 8643542.
- ^ a b “Protective cellular immunity: cytotoxic T-lymphocyte responses against dominant and recessive epitopes of influenza virus nucleoprotein induced by DNA immunization”. Journal of Virology 71 (4): 2715–21. (April 1997). doi:10.1128/JVI.71.4.2715-2721.1997. PMC 191393. PMID 9060624.
- ^ a b c “Antigen processing in vivo and the elicitation of primary CTL responses”. Journal of Immunology 154 (9): 4414–22. (May 1995). PMC 1952186. PMID 7722298.
- ^ a b c “Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines”. Journal of Immunology 158 (10): 4591–601. (May 1997). PMID 9144471.
- ^ a b “A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine”. Journal of Immunology 161 (5): 2325–32. (September 1998). PMID 9725227.
- ^ “Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12”. Journal of Immunology 158 (8): 4008–13. (April 1997). PMID 9103472.
- ^ a b “Long-term maintenance of B cell immunity to influenza virus hemagglutinin in mice following DNA-based immunization”. Virology 224 (1): 10–7. (October 1996). doi:10.1006/viro.1996.0501. PMID 8862394.
- ^ “Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers”. Vaccine 24 (21): 4482–9. (May 2006). doi:10.1016/j.vaccine.2005.08.013. PMID 16310901.
- ^ a b “Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle”. Journal of Cell Science. 103 103 ( Pt 4) (4): 1249–59. (December 1992). PMID 1487500.
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- ^ a b “Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope”. The Journal of Experimental Medicine 186 (9): 1481–6. (November 1997). doi:10.1084/jem.186.9.1481. PMC 2199124. PMID 9348305.
- ^ a b “DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA”. The Journal of Clinical Investigation 76 (6): 2182–90. (December 1985). doi:10.1172/JCI112226. PMC 424340. PMID 3001145.
- ^ “The production and characterization of murine monoclonal antibodies to a DNA receptor on human leukocytes”. Journal of Immunology 140 (9): 2937–42. (May 1988). PMID 2452195.
- ^ “Gene vaccination with naked plasmid DNA: mechanism of CTL priming”. The Journal of Experimental Medicine 184 (4): 1555–60. (October 1996). doi:10.1084/jem.184.4.1555. PMC 2192808. PMID 8879229.
- ^ “Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen-presenting cells”. Journal of Immunology 160 (12): 5707–18. (June 1998). PMID 9637479.
- ^ a b “Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations”. Journal of Immunology 158 (10): 4529–32. (May 1997). PMID 9144463.
- ^ “Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice”. Journal of Immunology 159 (4): 2001–8. (August 1997). PMID 9257867.
- ^ “DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state”. Proceedings of the National Academy of Sciences of the United States of America 93 (22): 12496–501. (October 1996). Bibcode: 1996PNAS...9312496M. doi:10.1073/pnas.93.22.12496. PMC 38020. PMID 8901610.
- ^ “IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model”. Journal of Immunology 163 (2): 884–92. (July 1999). PMID 10395683.
- ^ “Immunization with plasmid DNA encoding for the measles virus hemagglutinin and nucleoprotein leads to humoral and cell-mediated immunity”. Virology 225 (2): 293–9. (November 1996). doi:10.1006/viro.1996.0603. PMID 8918915.
- ^ a b c “Immunostimulatory DNA sequences necessary for effective intradermal gene immunization”. Science 273 (5273): 352–4. (July 1996). Bibcode: 1996Sci...273..352S. doi:10.1126/science.273.5273.352. PMID 8662521.
- ^ “Genetic vaccination against malaria infection by intradermal and epidermal injections of a plasmid containing the gene encoding the Plasmodium berghei circumsporozoite protein”. Infection and Immunity 68 (10): 5914–9. (October 2000). doi:10.1128/IAI.68.10.5914-5919.2000. PMC 101554. PMID 10992502.
- ^ a b “Improving protective immunity induced by DNA-based immunization: priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus”. Journal of Immunology 164 (11): 5905–12. (June 2000). doi:10.4049/jimmunol.164.11.5905. PMID 10820272.
- ^ “Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration”. Journal of Immunology 161 (4): 1875–82. (August 1998). PMID 9712056.
- ^ a b “CpG motifs in bacterial DNA trigger direct B-cell activation”. Nature 374 (6522): 546–9. (April 1995). Bibcode: 1995Natur.374..546K. doi:10.1038/374546a0. PMID 7700380.
- ^ “Contribution of CpG motifs to the immunogenicity of DNA vaccines”. Journal of Immunology 158 (8): 3635–9. (April 1997). PMID 9103425.
- ^ “Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs”. Proceedings of the National Academy of Sciences of the United States of America 95 (21): 12631–6. (October 1998). Bibcode: 1998PNAS...9512631K. doi:10.1073/pnas.95.21.12631. PMC 22882. PMID 9770537.
- ^ a b “CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma”. Proceedings of the National Academy of Sciences of the United States of America 93 (7): 2879–83. (April 1996). Bibcode: 1996PNAS...93.2879K. doi:10.1073/pnas.93.7.2879. PMC 39727. PMID 8610135.
- ^ “IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides”. Journal of Immunology 156 (2): 558–64. (January 1996). PMID 8543806.
- ^ “Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination”. Proceedings of the National Academy of Sciences of the United States of America 94 (17): 9378–83. (August 1997). Bibcode: 1997PNAS...94.9378L. doi:10.1073/pnas.94.17.9378. PMC 23198. PMID 9256490.
- ^ “Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine”. Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7648–53. (June 1998). Bibcode: 1998PNAS...95.7648S. doi:10.1073/pnas.95.13.7648. PMC 22711. PMID 9636204.
- ^ “Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques”. Infection and Immunity 69 (9): 5565–72. (September 2001). doi:10.1128/IAI.69.9.5565-5572.2001. PMC 98670. PMID 11500430.
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