カゼインキナーゼ1とは? わかりやすく解説

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カゼインキナーゼ1

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/06/05 03:52 UTC 版)

カゼインキナーゼ1: casein kinase 1、略称: CK1/CKIEC 2.7.11.1)は、真核生物のほとんどの細胞種でシグナル伝達経路の調節因子として機能するセリン・スレオニンキナーゼのファミリーである。CK1のアイソフォームWntシグナル伝達概日リズム転写因子-細胞質間移行、DNA修復転写に関与している[1]


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  16. ^ “Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity”. The Journal of Biological Chemistry 289 (38): 26344–56. (September 2014). doi:10.1074/jbc.M114.562165. PMC 4176241. PMID 25100726. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176241/. 
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  21. ^ “The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity”. Molecular Cell 13 (2): 213–23. (January 2004). doi:10.1016/S1097-2765(03)00503-3. PMID 14759367. 
  22. ^ “Cloning and characterization of rat casein kinase 1epsilon”. FEBS Letters 477 (1–2): 106–12. (July 2000). doi:10.1016/s0014-5793(00)01755-5. PMID 10899319. 
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  29. ^ “Regulation of the Neurospora circadian clock by casein kinase II”. Genes & Development 16 (8): 994–1006. (April 2002). doi:10.1101/gad.965102. PMC 152355. PMID 11959847. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC152355/. 
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  41. ^ “Casein kinase iδ mutations in familial migraine and advanced sleep phase”. Science Translational Medicine 5 (183): 183ra56, 1–11. (May 2013). doi:10.1126/scitranslmed.3005784. PMC 4220792. PMID 23636092. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220792/. 
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  43. ^ a b “Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6”. The Journal of Biological Chemistry 286 (4): 3129–38. (January 2011). doi:10.1074/jbc.M110.188565. PMC 3024805. PMID 21084295. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024805/. 
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  45. ^ a b c “Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus”. European Journal of Cell Biology 79 (4): 240–51. (April 2000). doi:10.1078/S0171-9335(04)70027-8. PMID 10826492. 


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