RBM10とは？ わかりやすく解説

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RBM10

(RNA-binding motif 10 から転送)

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/08/28 07:09 UTC 版)

RBM10（RNA-binding motif 10）はRBM10遺伝子にコードされたタンパク質[5][6][7][8]。ヒトの遺伝子はX染色体上のXp11.23に位置する。RBM10は選択的スプライシングを調節する因子である[9][10][11]。選択的スプライシングは転写後のpre-mRNAに作動して単一遺伝子から複数のタンパク質アイソフォームを生成する遺伝子発現の調節機構であり、細胞に機能的多様性と複雑性を作り出す[12]。RBM10は多数の遺伝子の発現に組み込まれ[9][10][13][14][15]、細胞増殖やアポトーシスなどさまざまな細胞過程に関与する[10][16]。RBM10遺伝子の変異は、出生前後に多くが致死となるX連鎖型先天異常のTARP症候群を引き起こし、成人でのさまざまながんなどの疾病に関わる[17][18][19][20][21][22]。


出典
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RBM10のお隣キーワード

RBE2

RBF

RBG 最強の85才

RBI

RBKデイリー

RBM

RBM10

RBMK-1000

RBMT

RBS

RBS 70

RBS-15

RBT

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