KHDRBS1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/04/10 04:36 UTC 版)
KHDRBS1（KH domain-containing, RNA-binding, signal transduction-associated protein 1）またはSam68（Src-associated substrate in mitosis of 68 kDa）は、ヒトではKHDRBS1遺伝子にコードされるタンパク質である[5][6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000121774 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028790 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62”. Cell 69 (3): 551–8. (Jun 1992). doi:10.1016/0092-8674(92)90455-L. PMID 1374686.
- ^ “Salpalpha and Salpbeta, growth-arresting homologs of Sam68”. Gene 240 (1): 133–47. (Jan 2000). doi:10.1016/S0378-1119(99)00421-7. PMID 10564820.
- ^ “Entrez Gene: KH domain containing, RNA binding, signal transduction associated 1”. 2020年11月28日閲覧。
- ^ “The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs”. BMC Mol Biol 10 (47): 47. (May 2009). doi:10.1186/1471-2199-10-47. PMC 2697983. PMID 19457263.
- ^ “Specificity and determinants of Sam68 RNA binding. Implications for the biological function of K homology domains”. J Biol Chem 272 (43): 27274–27280. (Oct 1997). doi:10.1074/jbc.272.43.27274. PMID 9341174.
- ^ “Sam68 regulates a set of alternatively spliced exons during neurogenesis”. Mol Cell Biol 29 (1): 201–13. (Jan 2009). doi:10.1128/MCB.01349-08. PMC 2612485. PMID 18936165.
- ^ a b “The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy”. EMBO J 29 (7): 1235–47. (Apr 2010). doi:10.1038/emboj.2010.19. PMC 2857462. PMID 20186123.
- ^ “SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1”. Cell 147 (7): 1601–14. (Dec 2011). doi:10.1016/j.cell.2011.11.028. PMC 3246220. PMID 22196734.
- ^ a b c d “The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis”. Mol Cell 46 (2): 187–99. (Apr 2012). doi:10.1016/j.molcel.2012.02.007. PMID 22424772.
- ^ “Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion”. Mol Cell Biol 26 (1): 362–70. (Jan 2006). doi:10.1128/MCB.26.1.362-370.2006. PMC 1317625. PMID 16354706.
- ^ a b “Signal-dependent regulation of splicing via phosphorylation of Sam68”. Nature 420 (6916): 691–5. (Dec 2002). doi:10.1038/nature01153. PMID 12478298.
- ^ Naor, David; Nedvetzki, Shlomo; Golan, Itshak; Melnik, Lora; Faitelson, Yoram (November 2002). “CD44 in cancer”. Critical Reviews in Clinical Laboratory Sciences 39 (6): 527–579. doi:10.1080/10408360290795574. ISSN 1040-8363. PMID 12484499.
- ^ a b Luxton, Hayley J.; Simpson, Benjamin S.; Mills, Ian G.; Brindle, Nicola R.; Ahmed, Zeba; Stavrinides, Vasilis; Heavey, Susan; Stamm, Stefan et al. (2019-08-23). “The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing”. Cancers 11 (9). doi:10.3390/cancers11091233. ISSN 2072-6694. PMC 6770463. PMID 31450747.
- ^ “The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells”. Oncogene 26 (30): 4372–82. (Jun 2007). doi:10.1038/sj.onc.1210224. PMID 17237817.
- ^ a b “The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x”. J Cell Biol 176 (7): 929–39. (Mar 2007). doi:10.1083/jcb.200701005. PMC 2064079. PMID 17371836.
- ^ Richard S (2010). Reaching for the stars: Linking RNA binding proteins to diseases. Advances in Experimental Medicine and Biology. 693. 142–57. doi:10.1007/978-1-4419-7005-3_10. ISBN 978-1-4419-7004-6. PMID 21189691
- ^ a b “Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor”. J Biol Chem 284 (46): 31903–13. (Nov 2009). doi:10.1074/jbc.M109.018465. PMC 2797261. PMID 19762470.
- ^ “Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members”. J Biol Chem 286 (24): 21062–72. (Jun 2011). doi:10.1074/jbc.M110.211409. PMC 3122167. PMID 21489997.
- ^ “Sam68 and ERKs regulate leptin-induced expression of OB-Rb mRNA in C2C12 myotubes”. Mol Cell Endocrinol 309 (1–2): 26–31. (Oct 2009). doi:10.1016/j.mce.2009.05.021. PMID 19524014.
- ^ “Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor”. Mol Cell 43 (2): 167–79. (Jul 2011). doi:10.1016/j.molcel.2011.05.007. PMC 3142289. PMID 21620750.
- ^ a b “Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis”. J Cell Biol 185 (2): 235–49. (Apr 2009). doi:10.1083/jcb.200811138. PMC 2700383. PMID 19380878.
- ^ “The RNA-binding protein Sam68 is a multifunctional player in human cancer”. Endocr Relat Cancer 18 (4): R91–R102. (Jul 2011). doi:10.1530/ERC-11-0041. hdl:2108/88068. PMID 21565971.
- ^ a b c d “Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss”. PLoS Genet 1 (6): e74. (Dec 2005). doi:10.1371/journal.pgen.0010074. PMC 1315279. PMID 16362077.
- ^ “Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development”. Hum Mol Genet 19 (24): 4886–94. (Dec 2010). doi:10.1093/hmg/ddq422. PMID 20881015.
- ^ “Motor coordination defects in mice deficient for the Sam68 RNA-binding protein”. Behav Brain Res 189 (2): 357–63. (Jun 2008). doi:10.1016/j.bbr.2008.01.010. PMID 18325609.
- ^ “Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis”. Oncogene 27 (4): 548–56. (Jan 2008). doi:10.1038/sj.onc.1210652. PMID 17621265.
[続きの解説]
「KHDRBS1」の続きの解説一覧
- 1 KHDRBS1とは
- 2 KHDRBS1の概要
- 3 機能
- 4 関連文献
- KHDRBS1のページへのリンク
