P-セレクチン
(CD62P から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/02/07 12:59 UTC 版)
P-セレクチン（英: P-selectin）またはCD62Pは、ヒトではSELP遺伝子にコードされるI型膜貫通タンパク質である[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000174175 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026580 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Cell-cell contact mechanisms”. Curr. Opin. Immunol. 4 (1): 33–7. (February 1992). doi:10.1016/0952-7915(92)90120-4. PMID 1375831.
- ^ “GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies”. J. Clin. Invest. 84 (1): 92–9. (July 1989). doi:10.1172/JCI114175. PMC 303957. PMID 2472431.
- ^ “The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction”. Hum. Mol. Genet. 7 (8): 1277–84. (August 1998). doi:10.1093/hmg/7.8.1277. PMID 9668170.
- ^ “Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells”. J. Biol. Chem. 273 (16): 10058–67. (April 1998). doi:10.1074/jbc.273.16.10058. PMID 9545353.
- ^ “Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway”. Mol. Biol. Cell 3 (3): 309–21. (March 1992). doi:10.1091/mbc.3.3.309. PMC 275532. PMID 1378326.
- ^ “Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140”. J. Biol. Chem. 264 (14): 7768–71. (May 1989). doi:10.1016/S0021-9258(18)83104-0. PMID 2470733.
- ^ “Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes”. J. Cell Biol. 121 (3): 655–64. (May 1993). doi:10.1083/jcb.121.3.655. PMC 2119562. PMID 7683689.
- ^ “Differential regulation of human and murine P-selectin expression and function in vivo”. The Journal of Experimental Medicine 207 (13): 2975–2987. (2010). doi:10.1084/jem.20101545. PMC 3005233. PMID 21149548.
- ^ “Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention”. Br J Pharmacol 126 (3): 537–550 [538]. (February 1999). doi:10.1038/sj.bjp.0702328. PMC 1565837. PMID 10188959.
- ^ “Association between platelet activation and fibrinolysis in acute stroke patients”. Neurosci. Lett. 384 (3): 305–9. (August 2005). doi:10.1016/j.neulet.2005.04.090. PMID 15916851.
- ^ “Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow”. Blood 95 (10): 3146–52. (May 2000). doi:10.1182/blood.V95.10.3146. PMID 10807781.
- ^ “Mechanisms that regulate the function of the selectins and their ligands”. Physiol. Rev. 79 (1): 181–213. (January 1999). doi:10.1152/physrev.1999.79.1.181. PMID 9922371.
- ^ “Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors”. J. Cell Biol. 142 (5): 1381–91. (September 1998). doi:10.1083/jcb.142.5.1381. PMC 2149355. PMID 9732297.
- ^ “Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP”. Blood 107 (7): 2736–44. (April 2006). doi:10.1182/blood-2004-07-2698. PMC 1895372. PMID 16332977.
- ^ “Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin”. Am. J. Respir. Cell Mol. Biol. 12 (3): 315–9. (March 1995). doi:10.1165/ajrcmb.12.3.7532979. PMID 7532979.
- ^ “Ezrin/Radixin/Moesin proteins and flotillins cooperate to promote uropod formation in T cells”. Front Immunol 4: 84. (2013). doi:10.3389/fimmu.2013.00084. PMC 3619129. PMID 23579783.
- ^ “E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung”. Br. J. Cancer 102 (3): 602–9. (February 2010). doi:10.1038/sj.bjc.6605492. PMC 2822933. PMID 20010946.
- ^ “P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis”. Arch. Immunol. Ther. Exp. (Warsz.) 54 (2): 75–84. (2006). doi:10.1007/s00005-006-0010-6. PMID 16648968.
- ^ a b “Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis”. Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3352–7. (March 2001). Bibcode: 2001PNAS...98.3352B. doi:10.1073/pnas.061615598. PMC 30657. PMID 11248082.
- ^ Gasic GJ (1984). “Role of plasma, platelets, and endothelial cells in tumor metastasis”. Cancer Metastasis Rev. 3 (2): 99–114. doi:10.1007/BF00047657. PMID 6386144.
- ^ “Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines”. Int. J. Cancer 120 (6): 1179–91. (March 2007). doi:10.1002/ijc.22424. PMID 17154173.
- ^ “P-selectin mediates metastatic progression through binding to sulfatides on tumor cells”. Glycobiology 17 (2): 185–96. (February 2007). doi:10.1093/glycob/cwl059. PMID 17043066.
- ^ “Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species”. Blood 70 (2): 551–7. (August 1987). doi:10.1182/blood.V70.2.551.551. PMID 2955820.
- ^ “The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trials”. J. Thromb. Haemost. 5 (4): 729–37. (April 2007). doi:10.1111/j.1538-7836.2007.02427.x. PMID 17408406.
- ^ “Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase”. Neoplasia 13 (5): 445–52. (May 2011). doi:10.1593/neo.101734. PMC 3084621. PMID 21532885.
- ^ Ataga, Kenneth I.; Kutlar, Abdullah; Kanter, Julie; Liles, Darla; Cancado, Rodolfo; Friedrisch, João; Guthrie, Troy H.; Knight-Madden, Jennifer et al. (2017). “Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease”. New England Journal of Medicine 376 (5): 429–439. doi:10.1056/NEJMoa1611770. PMC 5481200. PMID 27959701.
[続きの解説]
「P-セレクチン」の続きの解説一覧
- 1 P-セレクチンとは
- 2 P-セレクチンの概要
- 3 遺伝子と調節
- 4 機能
- 5 関連文献
- 6 関連項目
- P-セレクチンのページへのリンク
