プラスミノーゲンアクチベーターインヒビター1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/02/07 02:36 UTC 版)
プラスミノーゲンアクチベーターインヒビター1またはプラスミノーゲン活性化抑制因子1（英: plasminogen activator inhibitor 1、略称: PAI-1）は、ヒトではSERPINE1遺伝子にコードされるタンパク質である。PAI-1の血中濃度の上昇は、血栓症やアテローム性動脈硬化のリスク因子となる[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106366 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037411 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “PAI-1 and atherothrombosis”. Journal of Thrombosis and Haemostasis 3 (8): 1879–1883. (August 2005). doi:10.1111/j.1538-7836.2005.01420.x. PMID 16102055.
- ^ Tziastoudi, Maria; Dardiotis, Efthimios; Pissas, Georgios; Filippidis, Georgios; Golfinopoulos, Spyridon; Siokas, Vasileios; Tachmitzi, Sophia V.; Eleftheriadis, Theodoros et al. (2021-11-25). “Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach”. Genes 12 (12): 1887. doi:10.3390/genes12121887. ISSN 2073-4425. PMC 8701119. PMID 34946835.
- ^ Lijnen, H. R. (2001-07). “Plasmin and matrix metalloproteinases in vascular remodeling”. Thrombosis and Haemostasis 86 (1): 324–333. ISSN 0340-6245. PMID 11487021.
- ^ “Obesity and breast cancer: the roles of peroxisome proliferator-activated receptor-γ and plasminogen activator inhibitor-1”. PPAR Research 2009: 345320. (2009). doi:10.1155/2009/345320. PMC 2723729. PMID 19672469.
- ^ Hohensinner, Philipp J.; Baumgartner, Johanna; Kral-Pointner, Julia B.; Uhrin, Pavel; Ebenbauer, Benjamin; Thaler, Barbara; Doberer, Konstantin; Stojkovic, Stefan et al. (2017-10). “PAI-1 (Plasminogen Activator Inhibitor-1) Expression Renders Alternatively Activated Human Macrophages Proteolytically Quiescent”. Arteriosclerosis, Thrombosis, and Vascular Biology 37 (10): 1913–1922. doi:10.1161/ATVBAHA.117.309383. ISSN 1524-4636. PMC 5627534. PMID 28818858.
- ^ Morange, P. E.; Alessi, M. C.; Verdier, M.; Casanova, D.; Magalon, G.; Juhan-Vague, I. (1999-05). “PAI-1 produced ex vivo by human adipose tissue is relevant to PAI-1 blood level”. Arteriosclerosis, Thrombosis, and Vascular Biology 19 (5): 1361–1365. doi:10.1161/01.atv.19.5.1361. ISSN 1079-5642. PMID 10323791.
- ^ Minowa, H.; Takahashi, Y.; Tanaka, T.; Naganuma, K.; Ida, S.; Maki, I.; Yoshioka, A. (1999). “Four cases of bleeding diathesis in children due to congenital plasminogen activator inhibitor-1 deficiency”. Haemostasis 29 (5): 286–291. doi:10.1159/000022514. ISSN 0301-0147. PMID 10754381.
- ^ Nam, Da-Eun; Seong, Hae Chang; Hahn, Young S. (2021). “Plasminogen Activator Inhibitor-1 and Oncogenesis in the Liver Disease”. Journal of Cellular Signaling 2 (3): 221–227. doi:10.33696/signaling.2.054. ISSN 2692-0638. PMC 8525887. PMID 34671766.
- ^ Ghosh, Asish K.; Vaughan, Douglas E. (2012-02). “PAI-1 in tissue fibrosis”. Journal of Cellular Physiology 227 (2): 493–507. doi:10.1002/jcp.22783. ISSN 1097-4652. PMC 3204398. PMID 21465481.
- ^ “Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives”. Mechanisms of Ageing and Development 199: 111572. (October 2021). doi:10.1016/j.mad.2021.111572. PMID 34536446.
- ^ “Cellular senescence in the aging and diseased kidney”. Journal of Cell Communication and Signaling 12 (1): 69–82. (March 2018). doi:10.1007/s12079-017-0434-2. PMC 5842195. PMID 29260442.
- ^ van Leeuwen, R. T.; Kol, A.; Andreotti, F.; Kluft, C.; Maseri, A.; Sperti, G. (1994-07). “Angiotensin II increases plasminogen activator inhibitor type 1 and tissue-type plasminogen activator messenger RNA in cultured rat aortic smooth muscle cells”. Circulation 90 (1): 362–368. doi:10.1161/01.cir.90.1.362. ISSN 0009-7322. PMID 8026020.
- ^ “Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization”. Journal of Medicinal Chemistry 47 (14): 3491–3494. (July 2004). doi:10.1021/jm049766q. PMID 15214776.
- ^ “Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1”. Scientific Reports 6: 36462. (November 2016). Bibcode: 2016NatSR...636462P. doi:10.1038/srep36462. PMC 5120274. PMID 27876785.
- ^ “Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence”. Circulation 128 (21): 2318–2324. (November 2013). doi:10.1161/CIRCULATIONAHA.113.003192. PMC 3933362. PMID 24092817.
- ^ “Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity”. The Journal of Biological Chemistry 276 (38): 35305–35311. (September 2001). doi:10.1074/jbc.M104028200. PMID 11418606.
[続きの解説]
「プラスミノーゲンアクチベーターインヒビター1」の続きの解説一覧
- 1 プラスミノーゲンアクチベーターインヒビター1とは
- 2 プラスミノーゲンアクチベーターインヒビター1の概要
- 3 遺伝子
- 4 相互作用
- プラスミノーゲンアクチベーターインヒビター1のページへのリンク
