ガンマ‐セクレターゼ【gamma-secretase】
γ-セクレターゼ
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/03/11 04:44 UTC 版)
γ-セクレターゼ（英: gamma secretase）は、複数のサブユニットからなるプロテアーゼ複合体で、膜内切断プロテアーゼ（膜貫通タンパク質を膜貫通ドメイン内で切断するプロテアーゼ）の一種である。アルツハイマー病の発病と関わりがあると考えられている。
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- ^ “gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase”. Science 294 (5549): 2179–81. (2001). doi:10.1126/science.1065412. PMID 11679632.
- ^ “A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions”. EMBO J 21 (8): 1948–56. (2002). doi:10.1093/emboj/21.8.1948. PMC 125968. PMID 11953314.
- ^ “A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations”. Cell 114 (5): 635–45. (2003). doi:10.1016/j.cell.2003.08.008. PMID 13678586.
- ^ “Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling”. EMBO J 25 (6): 1242–52. (2006). doi:10.1038/sj.emboj.7601031. PMC 1422162. PMID 16511561.
- ^ “Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide”. J Biol Chem 277 (47): 44754–9. (2002). doi:10.1074/jbc.M206872200. PMID 12223485.
[続きの解説]
「γ-セクレターゼ」の続きの解説一覧
- 1 γ-セクレターゼとは
- 2 γ-セクレターゼの概要
- 3 作用
- 4 出典
- γ-セクレターゼのページへのリンク
