延長因子G
EF-G
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2018/12/29 05:16 UTC 版)
EF-G (elongation factor G) は、タンパク質の翻訳に関与する細菌の翻訳伸長因子であり、歴史的にはtranslocaseという名称でも知られる。EF-Gは GTPアーゼであり、tRNAとmRNAのリボソーム中の移動(トランスロケーション)を触媒する[1]。
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- ^ a b Das, Debasis; Samanta, Dibyendu; Bhattacharya, Arpita; Basu, Arunima; Das, Anindita; Ghosh, Jaydip; Chakrabarti, Abhijit; Gupta, Chanchal Das (2017年1月18日). “A Possible Role of the Full-Length Nascent Protein in Post-Translational Ribosome Recycling” (英語). PLOS ONE 12 (1): e0170333. doi:10.1371/journal.pone.0170333. ISSN 1932-6203 .
- ^ “Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G”. Molecular Cell 18 (6): 675–686. (2005年). doi:10.1016/j.molcel.2005.05.016. PMID 15949442.
- ^ Hirokawa, Go; Nijman, Romana M.; Raj, V. Samuel; Kaji, Hideko; Igarashi, Kazuei; Kaji, Akira (2005年8月1日). “The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits” (英語). RNA 11 (8): 1317–1328. doi:10.1261/rna.2520405. ISSN 1355-8382. PMID 16043510 .
- ^ a b Walter, Justin D.; Hunter, Margaret; Cobb, Melanie; Traeger, Geoff; Spiegel, P. Clint (2012年1月1日). “Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4” (英語). Nucleic Acids Research 40 (1): 360–370. doi:10.1093/nar/gkr623. ISSN 0305-1048 .
- ^ a b Bulkley, David; Brandi, Letizia; Polikanov, Yury S.; Fabbretti, Attilio; O’Connor, Michael; Gualerzi, Claudio O.; Steitz, Thomas A.. “The Antibiotics Dityromycin and GE82832 Bind Protein S12 and Block EF-G-Catalyzed Translocation”. Cell Reports 6 (2): 357–365. doi:10.1016/j.celrep.2013.12.024.
- ^ a b Belardinelli, Riccardo; Rodnina, Marina V. (2017年9月5日). “Effect of Fusidic Acid on the Kinetics of Molecular Motions During EF-G-Induced Translocation on the Ribosome” (英語). Scientific Reports 7 (1). doi:10.1038/s41598-017-10916-8. ISSN 2045-2322 .
- ^ Koripella, Ravi Kiran; Chen, Yang; Peisker, Kristin; Koh, Cha San; Selmer, Maria; Sanyal, Suparna. “Mechanism of Elongation Factor-G-mediated Fusidic Acid Resistance and Fitness Compensation inStaphylococcus aureus”. Journal of Biological Chemistry 287 (36): 30257–30267. doi:10.1074/jbc.m112.378521.
- ^ “Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics”. FEMS Microbiology Letters 247 (2): 215–20. (2005年6月). doi:10.1016/j.femsle.2005.05.007. PMID 15935566 .
- ^ “Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp”. Molecular Microbiology 37 (1): 98–107. (2000年7月). doi:10.1046/j.1365-2958.2000.01967.x. PMID 10931308 .
- ^ a b G C Atkinson; S L Baldauf (2011年). “Evolution of elongation factor G and the origins of mitochondrial and chloroplast forms”. Molecular Biology and Evolution 28 (3): 1281–92. doi:10.1093/molbev/msq316. PMID 21097998.
- ^ a b Margus, Tõnu; Remm, Maido; Tenson, Tanel (2011年8月4日). “A Computational Study of Elongation Factor G (EFG) Duplicated Genes: Diverged Nature Underlying the Innovation on the Same Structural Template” (英語). PLOS ONE 6 (8): e22789. doi:10.1371/journal.pone.0022789. ISSN 1932-6203 .
- ^ Tsuboi, Masafumi; Morita, Hiroyuki; Nozaki, Yusuke; Akama, Kenta; Ueda, Takuya; Ito, Koichi; Nierhaus, Knud H.; Takeuchi, Nono. “EF-G2mt Is an Exclusive Recycling Factor in Mammalian Mitochondrial Protein Synthesis”. Molecular Cell 35 (4): 502–510. doi:10.1016/j.molcel.2009.06.028 .
- 1 EF-Gとは
- 2 EF-Gの概要
- 3 翻訳終結における機能
- 4 関連項目
- E・F・Gのページへのリンク