Weblio 辞書 > 固有名詞の種類 > 病気・健康 > 病気・けが > 病気 > 病気の別名 > メタボリックシンドロームの意味・解説 

メタボリック シンドローム [10] 【metabolic syndrome】


英訳・(英)同義/類義語:metabolic syndrome




 メタボリックシンドロームの概念のいわば前身で、上半身肥満、糖代謝異常糖尿病)、高中脂肪血症(高脂血症)、高血圧合併した状態をさします1989年アメリカ研究者カプランKaplan NM)によって提唱され、冠動脈疾患による死亡率が高く、まさに死の序曲奏でるという意味合いから「死の四重奏(The Deadly Quartet)」と呼ばれました。


メタボリックシンドロームとは、肥満伴って内臓脂肪蓄積し、内臓脂肪働きにより病的な異常がもたらされる結果軽度の糖代謝脂質代謝の異常、あるいは血圧の上昇が起こり個々病態軽度でもこれらの病態重なり合って動脈硬化による心血管病のリスクが高まってい病態を言います。動脈硬化症心血管病は生命関わる病態であり、治療後の生活にも大きな支障与え可能性があることから、その予防は重要となります。 メタボリックシンドロームは内臓脂肪蓄積背景に糖代謝異常空腹時血糖値110mg/dl以上)、脂質代謝異常(中性脂肪150mg/dl以上またはHDL40mg/ml未満)、高血圧最大130mmHg以上または最小85mmHg以上)のうち2つ以上があてはまる場合診断されます。しかし、適正な摂取エネルギー量を知り、過食避け、適度な運動継続することで予防が可能と考えられています。


2005 年に、今までの「マルチプルリスクファクター症候群」「シンドローム X」「死の四重奏」という言葉説明されていた概念統一化された名称のことです。生活習慣病肥満 (内臓脂肪型肥満) をベースに、高血圧高脂血症糖尿病相互に合併しやすいとする概念で、これらが合併することで動脈硬化がより加速度的進み脳卒中心筋梗塞といった重大な病気へと発展してしまうリスクの高い状態をいいます。


出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2017/09/20 07:54 UTC 版)

メタボリックシンドローム: Metabolic syndrome)とは、内臓脂肪型肥満(内臓肥満・腹部肥満)に高血糖高血圧脂質異常症のうち2つ以上の症状が一度に出ている状態をいう。日本語に訳すと代謝症候群、単にメタボとも言われる。

  1. ^ 滋賀医科大 上島弘嗣教授『日米共同調査』
  2. ^ a b Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
  3. ^ a b DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
  4. ^ a b Kaplan NM. The deadly quartet: upper body obesity, glucose intolerance, hypertriglyceridemia and hypertension. Arch Intern Med 1989; 149: 1514-1520.
  5. ^ Lemieux I, Pascot A, et al. Hypertriglyceridemic waist: a marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small dense LDL) in men? Circulation 2000; 102: 179-184.
  6. ^ Ridker PM, Wilson PW, et al. Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation 2004; 109: 2818-2825.
  7. ^ Dandona P, Aljada A, et al. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005; 111: 1448-1454.
  8. ^ Iso H, Kobayashi M, et al. Intake of fish and n-3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-based (JPHC) Study Cohort 1. Circulation 2006; 113: 195-202.
  9. ^ Ouellet V, Marois J, et al. Dietary cod protein improves insulin sensitivity in insulin-resistant men and women. Diabetes Care 2007; 30: 2816-2821.
  10. ^ a b Riserus U, Arnlov J, et al. Long-term predictors of insuli resistance. Role of lifestyle and metabolic factors in middle-aged men. Diabetes Care 2007; 30: 2928-2933.
  11. ^ Oh SW, Yoon YS, et al. Association between cigarette smoking and metabolic syndrome: the Korea National Health and Nutrition Examination Survey. Diabetes Care 2005; 28: 2064–2066.
  12. ^ Gustat J, Srinivasan SR, et al. Relation of self-rated measures of physical activity to multiple risk factors of insulin resistance syndrome in young adults: the Bogalusa Heart Study. J Clin Epidemiol 2002; 55: 997-1006.
  13. ^ Ford ES, Giles WH, et al. Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-359.
  14. ^ Apridonidze T, Essah PA, et al. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004; 90: 1929-1935.
  15. ^ Ruderman NB, Schneider SH, et al. The “metabolically-obese,” normal-weight individual. Am J Clin Nutr 1981; 34: 1617-1621.
  16. ^ Nakamura T, Tokunaga K, et al. Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Athyerosclerosis 1997; 107: 239-246.
  17. ^ Lamarche B, Tchernof A, et al. Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. JAMA 1998; 279: 1955-1961.
  18. ^ World Health Organization. Definition, diagnosis, and classification of diabetes mellitus and its complications: report of a WHO Consultation. Geneva, World Health Org, 1999.
  19. ^ Balkau B, Charles MA. Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabetes Med 1999; 16: 442-443.
  20. ^ Lemieux I, Pascot A, et al. Hypertriglyceridemic waist. A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation 2000; 102: 179-184.
  21. ^ Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497.
  22. ^ Einhorn D, Reaven GM, et al. American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract 2003; 9: 237-252.
  23. ^ Ridker PM, Wilson PWF, et al. Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation 2004; 109: 2818-2825.
  24. ^ Grundy SM, Cleeman JI, et al. Diagnosis and management of the metabolic syndrome: a statement for health care professionals: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-2752.
  25. ^ Kahn R, Buse J, et al. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2005; 28: 2289-2304.
  26. ^ a b Grundy SM. Does the metabolic syndrome exist? Diabetes Care 2006; 29: 1689-1692.
  27. ^ Kahn R. The metabolic syndrome (emperor) wears no clothes. Diabetes Care 2006; 29: 1693-1696.
  28. ^ a b c Reaven GM. The metabolic syndrome: is this diagnosis necessary? Am J Clin Nutr 2006; 83: 1237-1247.
  29. ^ Grundy SM. Does a diagnosis of metabolic syndrome have value in clinical practice. Am J Clin Nutr 2006; 83: 1248-1251.
  30. ^ Ferrannini E. Metabolic syndrome: a solution in search of a problem. J Clin Endocrinol Metab 2007; 92: 396-398.
  31. ^ Grundy SM. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab 2007; 92: 399-404.
  32. ^ Kahn R. Metabolic syndrome. Is it a syndrome? Does it matter. Circulation 2007; 115: 1806-1811.
  33. ^ Beaser RS, Levy P. Metabolic syndrome. A work in progress, but a useful construct. Circulation 2007; 115: 1812-1818.
  34. ^ Sundstrom J, Vallhagen E, et al. Risk associated with the metabolic syndrome versus the sum of its individual components. Diabetes Care 2006; 29: 1673-1674.
  35. ^ Eckel RH, Kahn R, et al. Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association. Circulation 2006; 113: 2943-2946.
  36. ^ Malik S, Wong ND, et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004; 110: 1245-1250.
  37. ^ McNeil AM, Rosamond WD, et al. The metabolic syndrome and 11-year risk of incident cardiovascular disease in the Atherosclerosis Risk in Communities Study. Diabetes Care 2005; 28: 385-390.
  38. ^ Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome. Diabetes Care 2005; 28: 1769-1778.
  39. ^ Wilson PWF, D’Agostino RB, et al. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005; 112: 3066-3072.
  40. ^ The DECODE Study Group, Qiao Q. Comparison of different definitions of the metabolic syndrome in relation to cardiovascular mortality in European men and women. Diabetologia 2006; 49: 2837-2846.
  41. ^ Gami AS, Witt BJ, et al. Metabolic syndrome and risk of incident cardiovascular events and death. J Am Coll Cardiol 2007; 49: 403-414.
  42. ^ Ninomia T, Kubo M, et al. Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population. The Hisayama Study. Stroke 2007; 38: 2063-2069.
  43. ^ Sone H, Tanaka S, et al. The new worldwide definition of metabolic syndrome is not a better diagnostic predictor of cardiovascular disease in Japanese diabetic patients than the existing definitions. Diabetes Care 2006; 29: 145-147.
  44. ^ Katzmarzyk PT, Janssen I, et al. The importance of waist circumference in the definition of metabolic syndrome. Prospective analyses of mortality in men. Diabetes Care 2006; 29: 404-409.
  45. ^ Chen H, Pan W. Probable blind spot in the International Diabetes Federation definition of metabolic syndrome. Obesity 2007; 15: 1096-1100.
  46. ^ Yoon YS, Lee ES, et al. The new definition of metabolic syndrome by the International Diabetes Federation is less likely to identify metabolically abnormal but non-obese individuals than the definition by the revised National Cholesterol Education Program: the Korea NHANES Study. Int J Obes 2007; 31: 528-534.
  47. ^ Tong PC, Kong AP, et al. The usefulness of the International Diabetes Federation and the National Cholesterol Education Program’s Adult Treatment Panel III definitions of the metabolic syndrome in predicting coronary heart disease in subjects with type 2 diabetes. Diabetes Care 2007; 30: 1206-1211.
  48. ^ Tanomsup S, Aekplakorn W, et al. A comparison of components of two definitions of the metabolic syndrome related to cardiovascular disease and all-cause mortality in a cohort study in Thailand. Diabetes Care 2007; 30: 2138-2140.
  49. ^ Lorenzo C, Serrano-Rios M, et al. Is waist circumference an essential component of the metabolic syndrome? Diabetes Care 2007; 30: 2141-2142.
  50. ^ Klein S, Allison DB, et al. Waist circumference and cardiometabolic risk: a consensus statement from Shaping America’s Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care 2007; 30: 1647-1652.
  51. ^ The Examination Committee of Criteria for “Obesity Disease” in Japan, the Japanese Society for the Study of Obesity. New Criteria for “Obesity Disease” in Japan. Circ J 2002; 66: 987-992.
  52. ^ The Examination Committee of Criteria for Metabolic Syndrome. The definition and criteria of metabolic syndrome. J Jpn Soc Intern Med 2005; 94: 794-809, (in Japanese).
  53. ^ Matsuzawa YM. Pathophysiology and molecular mechanism of visceral fat syndrome: the Japanese experience. Diabetes/Metab Rev 1997; 13: 3-13.
  54. ^ Pou KM, Massaro JM, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress. The Framingham Heart Study. Circulation 2007; 116: 1234-1241.
  55. ^ Wellen KE, Fucho R, et al. Coordinated regulation of nutrient and inflammatory response by STAMP2 is essential for metabolic homeostasis. Cell 2007; 129: 537-548.
  56. ^ Oda E. New criteria for ‘obesity disease’ in Japan. Circ J 2006; 70: 150.
  57. ^ Oda E, Watanabe K. Japanese criteria of metabolic syndrome. Circ J 2006; 70: 364.
  58. ^ Oda E. Cut points of waist circumference. Diabetes Care 2006; 29: 1188-1189.
  59. ^ Hayashi T, Boyko E, et al. Minimum waist and visceral fat values for identifying Japanese Americans at risk for the metabolic syndrome. Diabetes Care 2007; 30: 120-127.
  60. ^ Tsubota N. Misuse of regression analysis and correlation in “New criteria for ‘obesity disease’ in Japan”. Circ J 2007; 71: 2001.
  61. ^ Hara K, Matsushita Y, et al. A proposal for the cutoff point of waist circumference for the diagnosis of metabolic syndrome in the Japanese population. Diabetes Care 2006; 29: 1123-1124.
  62. ^ Miyawaki T, Hirata M, et al. Prevalence of metabolic syndrome in Japan by MONKS (Metabolic Syndrome and Abdominal Obesity at NTT West Kyoto Study). Nippon Rinsho 2006; 64 (Suppl 9): s84-s87.
  63. ^ Oizumi T, Daimon M, et al. A proposal for the cutoff point of wait circumference for the diagnosis of metabolic syndrome in the Japanese population. Circ J 2006; 70: 1663.
  64. ^ Ohkubo T, Kikuya M, et al. A proposal for the cutoff point of wait circumference for the diagnosis of metabolic syndrome in the Japanese population. Diabetes Care 2006; 29: 1986-1987.
  65. ^ a b c Kiyohara Y, Doi Y, et al. Actual evidence of metabolic syndrome. J Jpn Soc Intern Med 2006; 95: 1710-1715, (in Japanese).
  66. ^ Kadota A, Hozawa A, et al. Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-2000. Diabetes Care 2007; 30: 1533-1538.
  67. ^ Okamura T, Nakamura K, et al. Effect of combined cardiovascular risk factors on individual and population medical expenditures: A 10 year cohort study of National Health Insurance in a Japanese population. Circ J 2007; 71: 807-813.
  68. ^ Alverti KGMM, Zimmet P, et al. Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 2006; 23: 469-480.
  69. ^ Oda E, Abe M, et al. Considerable disagreement among definitions of metabolic syndrome for Japanese. Circ J 2007; 71:1239-1243.



出典:『Wiktionary』 (2010/11/10 13:37 UTC 版)


  1. ある人について、内臓肥満であり、かつ、(1)高血圧、(2)高中脂肪血症か低HDLコレステロール血症、(3)境界型糖尿病糖尿病3つのうちの2つを満たす状態。



IPA: //



英和和英テキスト翻訳>> Weblio翻訳





































Weblio 辞書情報提供元は参加元一覧にて確認できます。

Copyright (C) 2001-2017 Sanseido Co.,Ltd. All rights reserved.
株式会社 三省堂三省堂 Web Dictionary
Copyright (C) 2017 NII,NIG,TUS. All Rights Reserved.
(C)2017 Ministry of Health, Labour and Welfare, All Right reserved.
Copyright © Yakult Honsha Co.,Ltd.All Rights Reserved.Produced by Yakult Honsha Co.,Ltd.
Copyright © 2017 Healthcare Committee, Inc. all rights reserved
All text is available under the terms of the GNU Free Documentation License.
この記事は、ウィキペディアのメタボリックシンドローム (改訂履歴)の記事を複製、再配布したものにあたり、GNU Free Documentation Licenseというライセンスの下で提供されています。 Weblio辞書に掲載されているウィキペディアの記事も、全てGNU Free Documentation Licenseの元に提供されております。
Text is available under Creative Commons Attribution-ShareAlike (CC-BY-SA) and/or GNU Free Documentation License (GFDL).
Weblioに掲載されている「Wiktionary日本語版(日本語カテゴリ)」の記事は、Wiktionaryのメタボリックシンドローム (改訂履歴)の記事を複製、再配布したものにあたり、Creative Commons Attribution-ShareAlike (CC-BY-SA)もしくはGNU Free Documentation Licenseというライセンスの下で提供されています。

©2017 Weblio RSS