5-メチルシトシンとは? わかりやすく解説

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5-メチルシトシン

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/07/15 05:53 UTC 版)

5-メチルシトシン(5mC、m5Cなどと略されることが多い)またはC5-メチルシトシンとは、DNA塩基の一つであるシトシン(C)メチル化されたものである。


  1. ^ Wu, Xiaoji; Zhang, Yi (09 2017). “TET-mediated active DNA demethylation: mechanism, function and beyond”. Nature Reviews. Genetics 18 (9): 517–534. doi:10.1038/nrg.2017.33. ISSN 1471-0064. PMID 28555658. https://www.ncbi.nlm.nih.gov/pubmed/28555658. 
  2. ^ Matthews AP (2012). Physiological Chemistry. Williams & Wilkins Company/RareBooksClub.com. pp. 167. ISBN 1130145379 
  3. ^ Johnson TB, Coghill RD (1925). “The discovery of 5-methyl-cytosine in tuberculinic acid, the nucleic acid of the Tubercle bacillus”. J Am Chem Soc 47 (11): 2838–2844. doi:10.1021/ja01688a030. 
  4. ^ Grosjean H (2009). Nucleic Acids Are Not Boring Long Polymers of Only Four Types of Nucleotides: A Guided Tour. Landes Bioscience.
  5. ^ Vischer E, Zamenhof S, Chargaff E (1949). “Microbial nucleic acids: the desoxypentose nucleic acids of avian tubercle bacilli and yeast”. J Biol Chem 77 (1): 429–438. PMID 18107446. 
  6. ^ Hotchkiss RD (1948). “The quantitative separation of purines, pyrimidines and nucleosides by paper chromatography”. J Biol Chem 175 (1): 315–332. PMID 18107446. 
  7. ^ Squires JE, Patel HR, Nousch M, Sibbritt T, Humphreys DT, Parker BJ, Suter CM, Preiss T. (2012). “Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA”. Nucleic Acids Res 40 (11): 5023–5033. doi:10.1093/nar/gks144. PMID 22344696. 
  8. ^ Colot V, Rossignol JL (1999). “Eukaryotic DNA methylation as an evolutionary device”. Bioessays 21 (5): 402–411. doi:10.1002/(SICI)1521-1878(199905)21:5<402::AID-BIES7>3.0.CO;2-B. PMID 10376011. 
  9. ^ Bird, A. P. (1986 May 15-21). “CpG-rich islands and the function of DNA methylation”. Nature 321 (6067): 209–213. doi:10.1038/321209a0. ISSN 0028-0836. PMID 2423876. https://www.ncbi.nlm.nih.gov/pubmed/2423876. 
  10. ^ Ehrlich, M.; Wang, R. Y. (1981-06-19). “5-Methylcytosine in eukaryotic DNA”. Science (New York, N.Y.) 212 (4501): 1350–1357. doi:10.1126/science.6262918. ISSN 0036-8075. PMID 6262918. https://www.ncbi.nlm.nih.gov/pubmed/6262918. 
  11. ^ Sassa, A; Kanemaru, Y; Kamoshita, N; Honma, M; Yasui, M (2016-09-01). “Mutagenic consequences of cytosine alterations site-specifically embedded in the human genome” (英語). Genes and Environment 38 (1). doi:10.1186/s41021-016-0045-9. ISSN 1880-7062. PMC PMC5007816. PMID 27588157. https://genesenvironment.biomedcentral.com/articles/10.1186/s41021-016-0045-9. 
  12. ^ Chahwan R., Wontakal S.N., and Roa S. (2010). “Crosstalk between genetic and epigenetic information through cytosine deamination”. Trends in Genetics 26 (10): 443–448. doi:10.1016/j.tig.2010.07.005. PMID 20800313. 
  13. ^ Clark SJ, Harrison J, Paul CL, Frommer M (1994). “High sensitivity mapping of methylated cytosines”. Nucleic Acids Res. 22 (15): 2990–2997. doi:10.1093/nar/22.15.2990. PMC 310266. PMID 8065911. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310266/. 
  14. ^ Ponger, Loïc; Li, Wen-Hsiung (2005-04-01). “Evolutionary Diversification of DNA Methyltransferases in Eukaryotic Genomes” (英語). Molecular Biology and Evolution 22 (4): 1119–1128. doi:10.1093/molbev/msi098. ISSN 0737-4038. PMID 15689527. https://academic.oup.com/mbe/article/22/4/1119/1083517. 
  15. ^ Lyko, Frank (February 2018). “The DNA methyltransferase family: a versatile toolkit for epigenetic regulation” (英語). Nature Reviews Genetics 19 (2): 81–92. doi:10.1038/nrg.2017.80. ISSN 1471-0064. PMID 29033456. 
  16. ^ a b Robertson, K D; Uzvolgyi, E; Liang, G; Talmadge, C; Sumegi, J; Gonzales, F A; Jones, P A (1999-06-01). “The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.”. Nucleic Acids Research 27 (11): 2291–2298. doi:10.1093/nar/27.11.2291. ISSN 0305-1048. PMC 148793. PMID 10325416. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148793/. 
  17. ^ Wu, Xiaoji; Zhang, Yi (2017-05-30). “TET-mediated active DNA demethylation: mechanism, function and beyond”. Nature Reviews Genetics 18 (9): 517–534. doi:10.1038/nrg.2017.33. ISSN 1471-0056. PMID 28555658. 
  18. ^ Jia, Da; Jurkowska, Renata Z.; Zhang, Xing; Jeltsch, Albert; Cheng, Xiaodong (September 2007). “Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation” (英語). Nature 449 (7159): 248–251. Bibcode2007Natur.449..248J. doi:10.1038/nature06146. ISSN 1476-4687. PMC 2712830. PMID 17713477. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712830/. 
  19. ^ Lyko, Frank (February 2018). “The DNA methyltransferase family: a versatile toolkit for epigenetic regulation” (英語). Nature Reviews Genetics 19 (2): 81–92. doi:10.1038/nrg.2017.80. ISSN 1471-0064. PMID 29033456. 
  20. ^ Wu, Xiaoji; Zhang, Yi (2017-05-30). “TET-mediated active DNA demethylation: mechanism, function and beyond”. Nature Reviews Genetics 18 (9): 517–534. doi:10.1038/nrg.2017.33. ISSN 1471-0056. PMID 28555658. 
  21. ^ Song, Chun-Xiao; Szulwach, Keith E.; Dai, Qing; Fu, Ye; Mao, Shi-Qing; Lin, Li; Street, Craig; Li, Yujing et al. (2013-04-25). “Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming”. Cell 153 (3): 678–691. doi:10.1016/j.cell.2013.04.001. ISSN 1097-4172. PMC 3657391. PMID 23602153. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657391/. 
  22. ^ Ito, Shinsuke; Shen, Li; Dai, Qing; Wu, Susan C.; Collins, Leonard B.; Swenberg, James A.; He, Chuan; Zhang, Yi (2011-09-02). “Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine” (英語). Science 333 (6047): 1300–1303. Bibcode2011Sci...333.1300I. doi:10.1126/science.1210597. ISSN 0036-8075. PMC 3495246. PMID 21778364. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495246/. 
  23. ^ Lu, Xingyu; Zhao, Boxuan Simen; He, Chuan (2015-02-12). “TET Family Proteins: Oxidation Activity, Interacting Molecules, and Functions in Diseases”. Chemical Reviews 115 (6): 2225–2239. doi:10.1021/cr500470n. ISSN 0009-2665. PMC 4784441. PMID 25675246. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784441/. 
  24. ^ Xu, Wei; Yang, Hui; Liu, Ying; Yang, Ying; Wang, Ping; Kim, Se-Hee; Ito, Shinsuke; Yang, Chen et al. (2011-01-18). “Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases”. Cancer Cell 19 (1): 17–30. doi:10.1016/j.ccr.2010.12.014. ISSN 1535-6108. PMC 3229304. PMID 21251613. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229304/. 
  25. ^ a b c Ehrlich, Melanie (2009-12-01). “DNA hypomethylation in cancer cells”. Epigenomics 1 (2): 239–259. doi:10.2217/epi.09.33. ISSN 1750-1911. PMC 2873040. PMID 20495664. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873040/. 
  26. ^ Jones, Peter A. (1996-06-01). “DNA Methylation Errors and Cancer” (英語). Cancer Research 56 (11): 2463–2467. ISSN 0008-5472. PMID 8653676. https://cancerres.aacrjournals.org/content/56/11/2463. 
  27. ^ Robertson, K D; Uzvolgyi, E; Liang, G; Talmadge, C; Sumegi, J; Gonzales, F A; Jones, P A (1999-06-01). “The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.”. Nucleic Acids Research 27 (11): 2291–2298. doi:10.1093/nar/27.11.2291. ISSN 0305-1048. PMC 148793. PMID 10325416. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148793/. 
  28. ^ Hanahan, Douglas; Weinberg, Robert A. (2011-03-04). “Hallmarks of Cancer: The Next Generation” (English). Cell 144 (5): 646–674. doi:10.1016/j.cell.2011.02.013. ISSN 0092-8674. PMID 21376230. https://www.cell.com/cell/abstract/S0092-8674(11)00127-9. 
  29. ^ Horvath, Steve; Raj, Kenneth (June 2018). “DNA methylation-based biomarkers and the epigenetic clock theory of ageing” (英語). Nature Reviews Genetics 19 (6): 371–384. doi:10.1038/s41576-018-0004-3. ISSN 1471-0064. PMID 29643443. 
  30. ^ Horvath, Steve (2013-12-10). “DNA methylation age of human tissues and cell types”. Genome Biology 14 (10): 3156. doi:10.1186/gb-2013-14-10-r115. ISSN 1474-760X. PMC 4015143. PMID 24138928. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015143/. 
  31. ^ Hannum, Gregory; Guinney, Justin; Zhao, Ling; Zhang, Li; Hughes, Guy; Sadda, SriniVas; Klotzle, Brandy; Bibikova, Marina et al. (2013-01-24). “Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates”. Molecular Cell 49 (2): 359–367. doi:10.1016/j.molcel.2012.10.016. ISSN 1097-2765. PMC 3780611. PMID 23177740. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780611/. 
  32. ^ Levine, Morgan E.; Lu, Ake T.; Quach, Austin; Chen, Brian H.; Assimes, Themistocles L.; Bandinelli, Stefania; Hou, Lifang; Baccarelli, Andrea A. et al. (2018-04-17). “An epigenetic biomarker of aging for lifespan and healthspan”. Aging (Albany NY) 10 (4): 573–591. doi:10.18632/aging.101414. ISSN 1945-4589. PMC 5940111. PMID 29676998. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111/. 
  33. ^ Garagnani, Paolo; Bacalini, Maria G.; Pirazzini, Chiara; Gori, Davide; Giuliani, Cristina; Mari, Daniela; Blasio, Anna M. Di; Gentilini, Davide et al. (2012). “Methylation of ELOVL2 gene as a new epigenetic marker of age” (英語). Aging Cell 11 (6): 1132–1134. doi:10.1111/acel.12005. ISSN 1474-9726. PMID 23061750. 


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