コレステロール依存性細胞溶解素とは何？わかりやすく解説 Weblio辞書

コレステロール依存性細胞溶解素

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2019/01/27 09:58 UTC 版)

コレステロール依存性細胞溶解素（Cholesterol dependent cytolysin：CDC）は、グラム陽性細菌によって分泌されるβバレル型膜孔形成毒素のファミリーである。分泌された直後は50〜70kDaの水溶性単量体で、標的細胞膜に結合すると40個（またはそれ以上）の単量体で環状ホモオリゴマー複合体を形成する。^[1]複数の構造変化を介して、βバレルの膜貫通構造（直径約250Å以上）が形成され、標的細胞膜を貫く。CDCは標的細胞膜への結合に標的細胞膜中のコレステロールを必ずしも要求しないが、膜孔形成に必要とする。例えば、Streptococcus intermediusによって分泌されるインターメディシリン(ILY; TC# 1.C.12.1.5)は、コレステロールの存在とは無関係に、特異的タンパク質受容体のある標的膜にのみ結合するが、膜孔形成にコレステロールを要求する。ただし、CDCがどのようにコレステロールから活性の調節を受けるかは明らかになっていない。

脚注

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