TAR DNA結合タンパク質43
(TAR DNA-binding protein 43 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/10/07 08:47 UTC 版)
TAR DNA結合タンパク質43(TDP-43, 43kDaのトランス活性化応答DNA結合タンパク質)は、ヒトではTARDBP遺伝子によってコードされるタンパク質である[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000120948 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041459 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ Kuo, Pan-Hsien; Doudeva, Lyudmila G.; Wang, Yi-Ting; Shen, Che-Kun James; Yuan, Hanna S. (2009-4). “Structural insights into TDP-43 in nucleic-acid binding and domain interactions”. Nucleic Acids Research 37 (6): 1799–1808. doi:10.1093/nar/gkp013. ISSN 0305-1048. PMC 2665213. PMID 19174564.
- ^ “TARDBP TAR DNA binding protein [Homo sapiens (human) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2021年2月11日閲覧。
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- ^ Wang, I.-Fan; Wu, Lien-Szn; Chang, Hsiang-Yu; Shen, C.-K. James (2008-05). “TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor”. Journal of Neurochemistry 105 (3): 797–806. doi:10.1111/j.1471-4159.2007.05190.x. ISSN 1471-4159. PMID 18088371.
- ^ Caragounis, Aphrodite; Price, Katherine Ann; Soon, Cynthia P. W.; Filiz, Gulay; Masters, Colin L.; Li, Qiao-Xin; Crouch, Peter J.; White, Anthony R. (2010-05-01). “Zinc induces depletion and aggregation of endogenous TDP-43”. Free Radical Biology & Medicine 48 (9): 1152–1161. doi:10.1016/j.freeradbiomed.2010.01.035. ISSN 1873-4596. PMID 20138212.
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- ^ a b Mitra, Joy; Guerrero, Erika N.; Hegde, Pavana M.; Liachko, Nicole F.; Wang, Haibo; Vasquez, Velmarini; Gao, Junling; Pandey, Arvind et al. (2019-03-05). “Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects”. Proceedings of the National Academy of Sciences of the United States of America 116 (10): 4696–4705. doi:10.1073/pnas.1818415116. ISSN 0027-8424. PMC 6410842. PMID 30770445.
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- ^ Gendron, Tania F.; Rademakers, Rosa; Petrucelli, Leonard (2013). “TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43”. Journal of Alzheimer's disease : JAD 33 (Suppl 1): S35–S45. doi:10.3233/JAD-2012-129036. ISSN 1387-2877. PMC 3532959. PMID 22751173.
- ^ Babić Leko, Mirjana; Župunski, Vera; Kirincich, Jason; Smilović, Dinko; Hortobágyi, Tibor; Hof, Patrick R.; Šimić, Goran (2019-01-15). “Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion”. Behavioural Neurology 2019. doi:10.1155/2019/2909168. ISSN 0953-4180. PMC 6350563. PMID 30774737.
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[続きの解説]
「TAR DNA結合タンパク質43」の続きの解説一覧
- 1 TAR DNA結合タンパク質43とは
- 2 TAR DNA結合タンパク質43の概要
- 3 構造
- 4 外部リンク
- TAR DNA結合タンパク質43のページへのリンク
