インターロイキン-21
(Il21 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/01 08:13 UTC 版)
インターロイキン-21（英: interleukin-21、略称: IL-21）は、ヒトではIL21遺伝子によってコードされるタンパク質である[5][6][7]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138684 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027718 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c d “Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function”. Nature 408 (6808): 57–63. (November 2000). Bibcode: 2000Natur.408...57P. doi:10.1038/35040504. PMID 11081504.
- ^ “Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration”. Journal of Immunology 179 (9): 5886–96. (November 2007). doi:10.4049/jimmunol.179.9.5886. PMID 17947662.
- ^ a b “Entrez Gene: IL21 interleukin 21”. 2021年7月23日閲覧。
- ^ Parrish-Novak, Julia; Foster, Donald C.; Holly, Richard D.; Clegg, Christopher H. (2002-11). “Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses”. Journal of Leukocyte Biology 72 (5): 856–863. ISSN 0741-5400. PMID 12429707.
- ^ “T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells”. Journal of Immunology 173 (1): 68–78. (July 2004). doi:10.4049/jimmunol.173.1.68. PMID 15210760.
- ^ “IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner”. The Journal of Biological Chemistry 282 (48): 34605–10. (November 2007). doi:10.1074/jbc.M705100200. PMC 2323680. PMID 17884812.
- ^ “Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells”. The Journal of Experimental Medicine 196 (7): 969–77. (October 2002). doi:10.1084/jem.20020620. PMC 2194031. PMID 12370258.
- ^ “Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions”. Immunity 44 (1): 167–178. (January 2016). doi:10.1016/j.immuni.2015.12.011. PMID 26795249.
- ^ “IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production”. Journal of Immunology 178 (5): 2827–34. (March 2007). doi:10.4049/jimmunol.178.5.2827. PMID 17312126.
- ^ “Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha”. Blood 112 (8): 3339–47. (October 2008). doi:10.1182/blood-2008-01-134783. PMID 18684866.
- ^ “Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain”. Proceedings of the National Academy of Sciences of the United States of America 97 (21): 11439–44. (October 2000). doi:10.1073/pnas.200360997. PMC 17218. PMID 11016959.
- ^ “Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex”. Journal of Immunology 167 (1): 1–5. (July 2001). doi:10.4049/jimmunol.167.1.1. PMID 11418623.
- ^ a b “The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3”. Biochemistry 41 (27): 8725–31. (July 2002). doi:10.1021/bi0202023. PMID 12093291.
- ^ “A critical role for IL-21 in regulating immunoglobulin production”. Science 298 (5598): 1630–4. (November 2002). Bibcode: 2002Sci...298.1630O. doi:10.1126/science.1077002. PMID 12446913.
- ^ “IL-21 administration into the nostril alleviates murine allergic rhinitis”. Journal of Immunology 179 (10): 7157–65. (November 2007). doi:10.4049/jimmunol.179.10.7157. PMID 17982108.
- ^ “IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice”. Journal of Immunology 179 (12): 8554–61. (December 2007). doi:10.4049/jimmunol.179.12.8554. PMID 18056403.
- ^ “IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response”. Journal of Immunology 175 (4): 2261–9. (August 2005). doi:10.4049/jimmunol.175.4.2261. PMID 16081794.
- ^ “IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21”. Journal of Immunology 173 (2): 900–9. (July 2004). doi:10.4049/jimmunol.173.2.900. PMID 15240677.
- ^ “IL-21: roles in immunopathology and cancer therapy”. Tissue Antigens 74 (6): 467–79. (December 2009). doi:10.1111/j.1399-0039.2009.01382.x. PMID 19845910.
- ^ “Immunology. A chronic need for IL-21”. Science 324 (5934): 1525–6. (June 2009). doi:10.1126/science.1176487. PMID 19541985.
- ^ “Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)”. Blood 109 (9): 3873–80. (May 2007). doi:10.1182/blood-2006-09-045278. PMC 1874576. PMID 17192392.
- ^ a b c “HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function”. Journal of Virology 85 (2): 733–41. (January 2011). doi:10.1128/JVI.02030-10. PMC 3020027. PMID 21047960.
- ^ a b “IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication”. Journal of Leukocyte Biology 87 (5): 857–67. (May 2010). doi:10.1189/jlb.1009701. PMID 20103765.
- ^ “Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers”. Journal of Virology 85 (5): 2316–24. (March 2011). doi:10.1128/JVI.01476-10. PMC 3067790. PMID 21159862.
[続きの解説]
「インターロイキン-21」の続きの解説一覧
- 1 インターロイキン-21とは
- 2 インターロイキン-21の概要
- 3 遺伝子
- 4 薬剤開発
- インターロイキン-21のページへのリンク
