CXCR3
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2020/05/26 04:01 UTC 版)
ケモカインレセプターCXCR3はGタンパク質共役受容体であるCXCケモカインレセプターファミリーの1つである。他にGタンパク質共役受容体9 (GPR9) やCD183と呼ばれることもある。CXCR3には2つの変異体が知られている。その1つであるCXCR3-AがCXCケモカインであるCXCL9 (MIG) 、CXCL10 (IP-10) 、CXCL11 (I-TAC)に結合するが[5]、CXCR3-Bはそれらに加えてさらにCXCL4と結合することができる[6]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186810 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050232 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ Clark-Lewis I, Mattioli I, Gong JH, Loetscher P (2003). “Structure-function relationship between the human chemokine receptor CXCR3 and its ligands”. J. Biol. Chem. 278 (1): 289–95. doi:10.1074/jbc.M209470200. PMID 12417585.
- ^ Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F, Romagnani S, Serio M, Romagnani P (2003). “An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4”. J. Exp. Med. 197 (11): 1537–49. doi:10.1084/jem.20021897. PMC: 2193908. PMID 12782716.
- ^ Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B, Mackay CR (1998). “The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions”. J. Clin. Invest. 101 (4): 746–54. doi:10.1172/JCI1422. PMC: 508621. PMID 9466968.
- ^ Smit MJ, Verdijk P, van der Raaij-Helmer EM, Navis M, Hensbergen PJ, Leurs R, Tensen CP (2003). “CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase”. Blood 102 (6): 1959–65. doi:10.1182/blood-2002-12-3945. PMID 12750173.
- ^ “Entrez Gene: CXCR3 chemokine (C-X-C motif) receptor 3”. 2013年4月16日閲覧。
- ^ Yates CC, Whaley D, Kulasekeran P, Hancock WW, Lu B, Bodnar R, Newsome J, Hebda PA, Wells A (2007). “Delayed and Deficient Dermal Maturation in Mice Lacking the CXCR3 ELR-Negative CXC Chemokine Receptor”. Am. J. Pathol. 171 (2): 484–95. doi:10.2353/ajpath.2007.061092. PMC: 1934531. PMID 17600132.
- ^ Mach F, Sauty A, Iarossi AS, Sukhova GK, Neote K, Libby P, Luster AD (1999). “Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells”. J. Clin. Invest. 104 (8): 1041–50. doi:10.1172/JCI6993. PMC: 408576. PMID 10525042.
- ^ Sørensen TL, Tani M, Jensen J, Pierce V, Lucchinetti C, Folcik VA, Qin S, Rottman J, Sellebjerg F, Strieter RM, Frederiksen JL, Ransohoff RM (1999). “Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients”. J. Clin. Invest. 103 (6): 807–15. doi:10.1172/JCI5150. PMC: 408141. PMID 10079101.
- ^ Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW (2004). “Regulation of pulmonary fibrosis by chemokine receptor CXCR3”. J. Clin. Invest. 114 (2): 291–9. doi:10.1172/JCI200416861. PMC: 449741. PMID 15254596.
- ^ Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U, Holländer GA, Piali L (2002). “Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis”. Nat. Med. 8 (12): 1414–20. doi:10.1038/nm792. PMID 12415259.
- ^ Panzer U, Steinmetz OM, Paust HJ, Meyer-Schwesinger C, Peters A, Turner JE, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl RA (2007). “Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice”. J. Am. Soc. Nephrol. 18 (7): 2071–84. doi:10.1681/ASN.2006111237. PMID 17538187.
- ^ Hancock WW, Lu B, Gao W, Csizmadia V, Faia K, King JA, Smiley ST, Ling M, Gerard NP, Gerard C (2000). “Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection”. J. Exp. Med. 192 (10): 1515–20. doi:10.1084/jem.192.10.1515. PMC: 2193193. PMID 11085753.
- ^ Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, Netzel-Arnett S, Antalis T, Vogel SN, Fasano A. (2008). “Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3”. Gastroenterology 135 (1): 194–204.e3. doi:10.1053/j.gastro.2008.03.023. PMC: 2653457. PMID 18485912.
- ^ Afantitis A, Melagraki G, Sarimveis H, Igglessi-Markopoulou O, Kollias G (July 2008). “A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4] diazepane ureas”. Eur J Med Chem 44 (2): 877–84. doi:10.1016/j.ejmech.2008.05.028. PMID 18619714.
[続きの解説]
「CXCR3」の続きの解説一覧
- 1 CXCR3とは
- 2 CXCR3の概要
- 3 発現
- 4 薬理
- CXCR3のページへのリンク
