デオキシリボースリン酸アルドラーゼ
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/07/20 16:31 UTC 版)
デオキシリボースリン酸アルドラーゼ（英: deoxyribose-phosphate aldolase、略称: DERA、EC 4.1.2.4）は、以下の化学反応を触媒する酵素である。
- ^ Chambre, Domitille; Guérard-Hélaine, Christine; Darii, Ekaterina; Mariage, Aline; Petit, Jean-Louis; Salanoubat, Marcel; de Berardinis, Véronique; Lemaire, Marielle et al. (2019). “2-Deoxyribose-5-phosphate aldolase, a remarkably tolerant aldolase towards nucleophile substrates”. Chemical Communications 55 (52): 7498–7501. doi:10.1039/c9cc03361k. PMID 31187106.
- ^ a b Heine, Andreas; Luz, John G.; Wong, Chi-Huey; Wilson, Ian A. (October 2004). “Analysis of the Class I Aldolase Binding Site Architecture Based on the Crystal Structure of 2-Deoxyribose-5-phosphate Aldolase at 0.99Å Resolution”. Journal of Molecular Biology 343 (4): 1019–1034. doi:10.1016/j.jmb.2004.08.066. PMID 15476818.
- ^ Liu, Junjie; Wong, Chi-Huey (15 April 2002). “Aldolase-Catalyzed Asymmetric Synthesis of Novel Pyranose Synthons as a New Entry to Heterocycles and Epothilones”. Angewandte Chemie International Edition 41 (8): 1404–1407. doi:10.1002/1521-3773(20020415)41:8<1404::AID-ANIE1404>3.0.CO;2-G. PMID 19750780.
- ^ Lokanath, N. K.; Shiromizu, I.; Ohshima, N.; Nodake, Y.; Sugahara, M.; Yokoyama, S.; Kuramitsu, S.; Miyano, M. et al. (1 October 2004). “Structure of aldolase from Thermus thermophilus HB8 showing the contribution of oligomeric state to thermostability” (英語). Acta Crystallographica Section D 60 (10): 1816–1823. doi:10.1107/S0907444904020190. ISSN 0907-4449. PMID 15388928.
- ^ Dick, Markus; Weiergräber, Oliver H.; Classen, Thomas; Bisterfeld, Carolin; Bramski, Julia; Gohlke, Holger; Pietruszka, Jörg (19 January 2016). “Trading off stability against activity in extremophilic aldolases”. Scientific Reports 6 (1): 17908. Bibcode: 2016NatSR...617908D. doi:10.1038/srep17908. PMC: 4725968. PMID 26783049.
- ^ Lomax, MS; Greenberg, GR (August 1968). “Characteristics of the deo operon: role in thymine utilization and sensitivity to deoxyribonucleosides.”. Journal of Bacteriology 96 (2): 501–14. doi:10.1128/JB.96.2.501-514.1968. PMC: 252324. PMID 4877128.
- ^ Salleron, Lisa; Magistrelli, Giovanni; Mary, Camille; Fischer, Nicolas; Bairoch, Amos; Lane, Lydie (December 2014). “DERA is the human deoxyribose phosphate aldolase and is involved in stress response”. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843 (12): 2913–2925. doi:10.1016/j.bbamcr.2014.09.007. PMID 25229427.
- ^ HORINOUCHI, Nobuyuki; OGAWA, Jun; KAWANO, Takako; SAKAI, Takafumi; SAITO, Kyota; MATSUMOTO, Seiichiro; SASAKI, Mie; MIKAMI, Yoichi et al. (22 May 2014). “Efficient Production of 2-Deoxyribose 5-Phosphate from Glucose and Acetaldehyde by Coupling of the Alcoholic Fermentation System of Baker's Yeast and Deoxyriboaldolase-Expressing”. Bioscience, Biotechnology, and Biochemistry 70 (6): 1371–1378. doi:10.1271/bbb.50648. PMID 16794316.
- ^ a b Huffman, Mark A.; Fryszkowska, Anna; Alvizo, Oscar; Borra-Garske, Margie; Campos, Kevin R.; Canada, Keith A.; Devine, Paul N.; Duan, Da et al. (5 December 2019). “Design of an in vitro biocatalytic cascade for the manufacture of islatravir”. Science 366 (6470): 1255–1259. Bibcode: 2019Sci...366.1255H. doi:10.1126/science.aay8484. PMID 31806816.
- ^ GIJSEN, H. J. M.; WONG, C.-H. (18 August 2010). “ChemInform Abstract: Unprecedented Asymmetric Aldol Reactions with Three Aldehyde Substrates Catalyzed by 2-Deoxyribose-5-phosphate Aldolase.”. ChemInform 26 (15): no. doi:10.1002/chin.199515259. ISSN 0931-7597.
- ^ Jennewein, Stefan; Schürmann, Martin; Wolberg, Michael; Hilker, Iris; Luiten, Ruud; Wubbolts, Marcel; Mink, Daniel (May 2006). “Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase”. Biotechnology Journal 1 (5): 537–548. doi:10.1002/biot.200600020. PMID 16892289.
- ^ Patel, Ramesh N. (April 2018). “Biocatalysis for synthesis of pharmaceuticals”. Bioorganic & Medicinal Chemistry 26 (7): 1252–1274. doi:10.1016/j.bmc.2017.05.023. PMID 28648492.
- ^ Haridas, Meera; Abdelraheem, Eman M. M.; Hanefeld, Ulf (3 October 2018). “2-Deoxy-d-ribose-5-phosphate aldolase (DERA): applications and modifications”. Applied Microbiology and Biotechnology 102 (23): 9959–9971. doi:10.1007/s00253-018-9392-8. PMC: 6244999. PMID 30284013.
- ^ Dick, Markus; Hartmann, Rudolf; Weiergräber, Oliver H.; Bisterfeld, Carolin; Classen, Thomas; Schwarten, Melanie; Neudecker, Philipp; Willbold, Dieter et al. (2016). “Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies”. Chemical Science 7 (7): 4492–4502. doi:10.1039/c5sc04574f. PMC: 6016325. PMID 30155096.
[続きの解説]
「デオキシリボースリン酸アルドラーゼ」の続きの解説一覧
- 1 デオキシリボースリン酸アルドラーゼとは
- 2 デオキシリボースリン酸アルドラーゼの概要
- 3 生物学的機能
- 4 関連文献
- デオキシリボースリン酸アルドラーゼのページへのリンク
