HMGB1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/12/30 05:41 UTC 版)
HMGB1（high mobility group box 1）もしくはHMG-1（high-mobility group protein 1）、アンフォテリン（英: amphoterin）は、ヒトではHMGB1遺伝子にコードされるタンパク質である[3][4]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000189403 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ “The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13”. Genomics 35 (2): 367–71. (July 1996). doi:10.1006/geno.1996.0369. PMID 8661151.
- ^ “Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain”. Journal of Neurochemistry 77 (1): 120–31. (April 2001). doi:10.1046/j.1471-4159.2001.t01-1-00209.x. PMID 11279268.
- ^ “HMG proteins: dynamic players in gene regulation and differentiation”. Current Opinion in Genetics & Development 15 (5): 496–506. (October 2005). doi:10.1016/j.gde.2005.08.007. PMID 16102963.
- ^ a b c d “HMGB1: endogenous danger signaling”. Molecular Medicine 14 (7–8): 476–84. (2008). doi:10.2119/2008-00034.Klune. PMC 2323334. PMID 18431461.
- ^ “Single-molecule studies of high-mobility group B architectural DNA bending proteins”. Biophysical Reviews 9 (1): 17–40. (February 2017). doi:10.1007/s12551-016-0236-4. PMC 5331113. PMID 28303166.
- ^ “RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes”. Nucleic Acids Research 41 (4): 2437–54. (February 2013). doi:10.1093/nar/gks1294. PMC 3575807. PMID 23293004.
- ^ “HMG-1 as a late mediator of endotoxin lethality in mice”. Science 285 (5425): 248–51. (July 1999). doi:10.1126/science.285.5425.248. PMID 10398600.
- ^ “A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release”. Proceedings of the National Academy of Sciences of the United States of America 107 (26): 11942–7. (June 2010). Bibcode: 2010PNAS..10711942Y. doi:10.1073/pnas.1003893107. PMC 2900689. PMID 20547845.
- ^ “Targeting HMGB1 in inflammation”. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1799 (1–2): 149–56. (2010). doi:10.1016/j.bbagrm.2009.11.019. PMC 4533842. PMID 19948257.
- ^ a b “Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases”. Cells 9 (1): 41. (2019). doi:10.3390/cells9010041. PMC 7017201. PMID 31877876.
- ^ “Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination”. Gene Therapy 18 (11): 1070–7. (November 2011). doi:10.1038/gt.2011.59. PMC 4141626. PMID 21544096.
- ^ “HMGB1 mediates endogenous TLR2 activation and brain tumor regression”. PLOS Medicine 6 (1): e10. (January 2009). doi:10.1371/journal.pmed.1000010. PMC 2621261. PMID 19143470.
- ^ “Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein”. The Journal of Biological Chemistry 276 (10): 7534–40. (March 2001). doi:10.1074/jbc.M008143200. PMID 11106654.
- ^ “HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences”. The Journal of Biological Chemistry 277 (9): 7021–8. (March 2002). doi:10.1074/jbc.M108417200. PMID 11748221.
- ^ “RAGE and TLRs: relatives, friends or neighbours?”. Molecular Immunology 56 (4): 739–44. (December 2013). doi:10.1016/j.molimm.2013.07.008. PMID 23954397.
- ^ “High mobility group box 1 protein interacts with multiple Toll-like receptors”. American Journal of Physiology. Cell Physiology 290 (3): C917-24. (March 2006). doi:10.1152/ajpcell.00401.2005. PMID 16267105.
- ^ “HMGB1 loves company”. Journal of Leukocyte Biology 86 (3): 573–6. (September 2009). doi:10.1189/jlb.1008585. PMID 19414536.
- ^ “High mobility group box protein 1 (HMGB1)-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor”. Molecular Medicine 18 (2): 224–30. (March 2012). doi:10.2119/molmed.2011.00327. PMC 3320135. PMID 22076468.
- ^ “Dealing with death: HMGB1 as a novel target for cancer therapy”. Current Opinion in Investigational Drugs 4 (12): 1405–1409. (December 2003). PMID 14763124.
- ^ “Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?”. Molecular Medicine 26 (1): 42. (May 2020). doi:10.1186/s10020-020-00172-4. PMC 7203545. PMID 32380958.
- ^ “Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection”. BMC Medicine 20 (1): 26. (January 2022). doi:10.1186/s12916-021-02228-6. PMC 8758383. PMID 35027067.
- ^ a b “HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice”. EMBO Molecular Medicine 7 (1): 78–101. (January 2015). doi:10.15252/emmm.201404392. PMC 4309669. PMID 25510912.
- ^ “Increased serum concentrations of high mobility group box 1 (HMGB1) protein in children with Autism Spectrum Disorder”. Children 8 (6): 478. (2021). doi:10.3390/children8060478. PMC 8228126. PMID 34198762.
- ^ “Increased serum concentrations of high mobility group box 1 (HMGB1) protein in children with Autism Spectrum Disorder”. Children 8 (6): 478. (2021). doi:10.3390/children8060478. PMC 8228126. PMID 34198762.
[続きの解説]
「HMGB1」の続きの解説一覧
- 1 HMGB1とは
- 2 HMGB1の概要
- 3 機能
- 4 臨床的意義
- 5 関連文献
- 6 外部リンク
- HMGB1のページへのリンク
