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GLUT4

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/11/16 15:23 UTC 版)

GLUT4 (glucose transporter type 4) は、ヒトではSLC2A4遺伝子にコードされているタンパク質である。Solute carrier family 2, facilitated glucose transporter member 4という別名でも知られる。GLUT4は、インスリンによって調節されるグルコーストランスポーターで、主に脂肪組織と横紋筋（骨格筋と心筋）に見つかる。これまで知られていたグルコーストランスポーターとは別物であると確定できたという最初の報告は、1988年にDavid Jamesによってもたらされた^[1]。GLUT4をコードする遺伝子は1989年にクローニングされ^[2]^[3]、マッピングされた^[4]。

注釈

^ ただし、別にグルコースを摂取していなくとも、体内では糖新生によってグルコースは合成される。何よりも、結局、摂取したエネルギーが、消費しているエネルギーよりも多い時は、脂肪細胞の肥大と過形成を引き起こし、肥満につながる。したがって、単純にグルコースを摂取しなければ、肥満が解消されるというわけではない。

出典

^ “Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein”. Nature 333 (6169): 183–5. (May 1988). doi:10.1038/333183a0. PMID 3285221.
^ “Molecular cloning and characterization of an insulin-regulatable glucose transporter”. Nature 338 (6210): 83–7. (March 1989). doi:10.1038/338083a0. PMID 2645527.
^ “Identification of a novel gene encoding an insulin-responsive glucose transporter protein”. Cell 57 (2): 305–15. (April 1989). doi:10.1016/0092-8674(89)90968-9. PMID 2649253.
^ “Polymorphic human insulin-responsive glucose-transporter gene on chromosome 17p13”. Diabetes 38 (8): 1072–5. (August 1989). doi:10.2337/diabetes.38.8.1072. PMID 2568955.
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^ ^a ^b “The UBX domain: a widespread ubiquitin-like module”. Journal of Molecular Biology 307 (1): 17–24. (March 2001). doi:10.1006/jmbi.2000.4462. PMID 11243799.
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