ヘファエスチン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/02/23 02:20 UTC 版)
ヘファエスチンもしくはヘファスチン（英: hephaestin、HEPH）は、ヒトではHEPH遺伝子にコードされるタンパク質である[5][6][7]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000089472 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031209 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ^ a b Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ (February 1999). “Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse”. Nat. Genet. 21 (2): 195–9. doi:10.1038/5979. PMID 9988272.
- ^ “Entrez Gene: Hephaestin”. 2023年2月18日閲覧。
- ^ “Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency”. J. Nutr. 136 (5): 1236–41. (May 2006). doi:10.1093/jn/136.5.1236. PMID 16614410.
- ^ Hudson, David M.; Curtis, Susan B.; Smith, Valerie C.; Griffiths, Tanya A. M.; Wong, Ann Y. K.; Scudamore, Charles H.; Buchan, Alison M. J.; MacGillivray, Ross T. A. (2010-03). “Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic {beta}-cells”. American Journal of Physiology. Gastrointestinal and Liver Physiology 298 (3): G425–432. doi:10.1152/ajpgi.00453.2009. ISSN 1522-1547. PMID 20019163.
- ^ Wang, Ya-Fang; Zhang, Jie; Su, Yi; Shen, Yan-Yan; Jiang, Dong-Xian; Hou, Ying-Yong; Geng, Mei-Yu; Ding, Jian et al. (2017-08-17). “G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin”. Nature Communications 8 (1): 274. doi:10.1038/s41467-017-00350-9. ISSN 2041-1723. PMC 5561105. PMID 28819251.
- ^ a b c “Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice”. Blood 103 (10): 3933–9. (May 2004). doi:10.1182/blood-2003-09-3139. PMID 14751926.
- ^ C. N. Roy; C. A. Enns (December 2000). “Iron homeostasis: new tales from the crypt”. Blood 96 (13): 4020–4027. doi:10.1182/blood.V96.13.4020. PMID 11110669.
- ^ a b Y. M. Kuo; T. Su; H. Chen; Z. Attieh; B. A. Syed; A. T. McKie; G. J. Anderson; J. Gitschier et al. (February 2004). “Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse”. Gut 53 (2): 201–206. doi:10.1136/gut.2003.019026. PMC 1774920. PMID 14724150.
- ^ “Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity”. Biochemistry 44 (45): 14725–31. (November 2005). doi:10.1021/bi051559k. hdl:2429/18540. PMID 16274220.
- ^ Jiri Petrak; Daniel Vyoral (June 2005). “Hephaestin--a ferroxidase of cellular iron export”. The International Journal of Biochemistry & Cell Biology 37 (6): 1173–1178. doi:10.1016/j.biocel.2004.12.007. PMID 15778082.
- ^ P. Bielli; L. Calabrese (September 2002). “Structure to function relationships in ceruloplasmin: a 'moonlighting' protein”. Cellular and Molecular Life Sciences 59 (9): 1413–1427. doi:10.1007/s00018-002-8519-2. PMID 12440766.
- ^ Basharut A. Syed; Nick J. Beaumont; Alpesh Patel; Claire E. Naylor; Henry K. Bayele; Christopher L. Joannou; Peter S. N. Rowe; Robert W. Evans et al. (March 2002). “Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin”. Protein Engineering 15 (3): 205–214. doi:10.1093/protein/15.3.205. PMID 11932491.
- ^ a b Huijun Chen; Trent Su; Zouhair K. Attieh; Tama C. Fox; Andrew T. McKie; Gregory J. Anderson; Chris D. Vulpe (September 2003). “Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency”. Blood 102 (5): 1893–1899. doi:10.1182/blood-2003-02-0347. PMID 12730111.
- ^ Brie K. Fuqua; Yan Lu; Deepak Darshan; David M. Frazer; Sarah J. Wilkins; Natalie Wolkow; Austin G. Bell; JoAnn Hsu et al. (2014). “The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice”. PLoS ONE 9 (6): e98792. Bibcode: 2014PLoSO...998792F. doi:10.1371/journal.pone.0098792. PMC 4045767. PMID 24896847.
- ^ Paul Hahn; Ying Qian; Tzvete Dentchev; Lin Chen; John Beard; Zena Leah Harris; Joshua L. Dunaief (September 2004). “Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration”. Proceedings of the National Academy of Sciences of the United States of America 101 (38): 13850–13855. Bibcode: 2004PNAS..10113850H. doi:10.1073/pnas.0405146101. PMC 518844. PMID 15365174.
- ^ Xining He; Paul Hahn; Jared Iacovelli; Robert Wong; Chih King; Robert Bhisitkul; Mina Massaro-Giordano; Joshua L. Dunaief (November 2007). “Iron homeostasis and toxicity in retinal degeneration”. Progress in Retinal and Eye Research 26 (6): 649–673. doi:10.1016/j.preteyeres.2007.07.004. PMC 2093950. PMID 17921041.
[続きの解説]
「ヘファエスチン」の続きの解説一覧
- 1 ヘファエスチンとは
- 2 ヘファエスチンの概要
- 3 機能
- 4 調節
- 5 関連項目
- ヘファエスチンのページへのリンク
