インターロイキン-18
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/09/18 03:36 UTC 版)
インターロイキン-18（英: interleukin-18、略称: IL-18）は、ヒトではIL18遺伝子にコードされるタンパク質である[5][6]。インターフェロンγ誘導因子（interferon-gamma inducing factor）とも呼ばれる。造血系細胞と非造血系細胞を含む多くの細胞種が、IL-18産生能力を持つ。IL-18は1989年にマウス脾臓細胞において、インターフェロンγ（IFN-γ）の産生を誘導する因子として最初に記載された[7]。もともと、IL-18は肝臓に位置するマクロファージであるクッパー細胞で産生されることが知られていたが、腸管上皮細胞、ケラチノサイト、内皮細胞などの非造血系細胞でも恒常的に発現している[8]。IL-18は自然免疫と獲得免疫の双方を調節し、その調節異常は自己免疫疾患や炎症疾患を引き起こす場合がある[9][10]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000150782 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039217 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Cloning of a new cytokine that induces IFN-gamma production by T cells”. Nature 378 (6552): 88–91. (November 1995). Bibcode: 1995Natur.378...88O. doi:10.1038/378088a0. PMID 7477296.
- ^ “The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci”. Genomics 51 (1): 161–3. (July 1998). doi:10.1006/geno.1998.5336. PMID 9693051.
- ^ “Endotoxin-induced serum factor that stimulates gamma interferon production”. Infection and Immunity 57 (2): 590–5. (February 1989). doi:10.1128/IAI.57.2.590-595.1989. PMC 313137. PMID 2492265.
- ^ “Interleukin-18 in Health and Disease”. International Journal of Molecular Sciences 20 (3): 649. (February 2019). doi:10.3390/ijms20030649. PMC 6387150. PMID 30717382.
- ^ “IL-1 Family Members in Cancer; Two Sides to Every Story” (英語). Frontiers in Immunology 10: 1197. (2019). doi:10.3389/fimmu.2019.01197. PMC 6567883. PMID 31231372.
- ^ “Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP”. Journal of Leukocyte Biology 97 (4): 665–75. (April 2015). doi:10.1189/jlb.5RU0714-360RR. PMID 25548255.
- ^ “Overview of interleukin-18: more than an interferon-gamma inducing factor”. Journal of Leukocyte Biology 63 (6): 658–64. (June 1998). doi:10.1002/jlb.63.6.658. PMID 9620656.
- ^ “Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme”. Science 275 (5297): 206–9. (January 1997). doi:10.1126/science.275.5297.206. PMID 8999548.
- ^ “Interleukin-18”. Methods 19 (1): 121–32. (September 1999). doi:10.1006/meth.1999.0837. PMID 10525448.
- ^ “Interleukin-18: Biological properties and role in disease pathogenesis”. Immunological Reviews 281 (1): 138–153. (January 2018). doi:10.1111/imr.12616. PMC 7165732. PMID 29247988.
- ^ a b “Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases”. BioMed Research International 2018: 3058640. (2018). doi:10.1155/2018/3058640. PMC 5899839. PMID 29805973.
- ^ “TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization”. Trends in Immunology 30 (9): 439–46. (September 2009). doi:10.1016/j.it.2009.06.001. PMID 19699681.
- ^ “Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor)”. 2007年11月5日閲覧。
- ^ “Interleukin-18 in Health and Disease”. International Journal of Molecular Sciences 20 (3): 649. (February 2019). doi:10.3390/ijms20030649. PMC 6387150. PMID 30717382.
- ^ a b E. Sánchez; R. J. Palomino-Morales; N. Ortego-Centeno; J. Jiménez-Alonso; M. A. González-Gay; M. A. López-Nevot; J. Sánchez-Román; E. de Ramón et al. (1 October 2009). Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus. 18. Oxford University Press. 3739–3748. doi:10.1093/hmg/ddp301. ISSN 0964-6906. OCLC 441948395. PMID 19584085
- ^ “Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients”. Fertility and Sterility 94 (1): 33–9. (June 2010). doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.
- ^ “Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto's thyroiditis”. International Journal of Experimental Pathology 91 (5): 420–5. (October 2010). doi:10.1111/j.1365-2613.2010.00715.x. PMC 3003839. PMID 20586818.
- ^ “Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells”. Journal of Neuroinflammation 9: 199. (August 2012). doi:10.1186/1742-2094-9-199. PMC 3458954. PMID 22898493.
- ^ “The Expression of Tristetraprolin and Its Relationship with Urinary Proteins in Patients with Diabetic Nephropathy”. PLOS ONE 10 (10): e0141471. (2015-10-30). Bibcode: 2015PLoSO..1041471L. doi:10.1371/journal.pone.0141471. PMC 4627660. PMID 26517838.
- ^ “Serum interleukin-18 levels are associated with nephropathy and atherosclerosis in Japanese patients with type 2 diabetes”. Diabetes Care 28 (12): 2890–5. (December 2005). doi:10.2337/diacare.28.12.2890. PMID 16306550.
- ^ “The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes”. PeerJ 7: e7079. (2019-06-11). doi:10.7717/peerj.7079. PMC 6568248. PMID 31218128.
- ^ “Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage”. Prog. Neurobiol. 178: 101610. (March 2019). doi:10.1016/j.pneurobio.2019.03.003. PMID 30923023.
[続きの解説]
「インターロイキン-18」の続きの解説一覧
- 1 インターロイキン-18とは
- 2 インターロイキン-18の概要
- 3 プロセシング
- 4 臨床的意義
- インターロイキン１８のページへのリンク
