核内低分子リボ核タンパク質
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/10/29 08:07 UTC 版)
核内低分子リボヌクレオタンパク質または核内低分子リボ核タンパク質（かくないていぶんしリボ ヌクレオ/かく タンパクしつ、英: small nuclear ribonucleoprotein、略称: snRNP）はRNA-タンパク質複合体であり、未修飾のpre-mRNAと結合し、他のさまざまなタンパク質とともにスプライソソームを形成する。スプライソソームはpre-mRNAのスプライシングを行う巨大なRNA-タンパク質複合体である。pre-mRNAからのイントロンの除去にはsnRNPの作用が必須であり、真核細胞の核内でのみ起こる転写後修飾の重要な過程である。ただし、U7 snRNAとタンパク質の複合体であるU7 snRNPはスプライシングには全く関与せず、ヒストンのpre-mRNAの3'ステムループ構造のプロセシングを担う[1]。
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- ^ Montemayor, Eric J.; Curran, Elizabeth C.; Liao, Hong Hong; Andrews, Kristie L.; Treba, Christine N.; Butcher, Samuel E.; Brow, David A. (2014-6). “Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution”. Nature Structural & Molecular Biology 21 (6): 544–551. doi:10.1038/nsmb.2832. ISSN 1545-9985. PMC 4141773. PMID 24837192.
- ^ Zhou, Lijun; Hang, Jing; Zhou, Yulin; Wan, Ruixue; Lu, Guifeng; Yin, Ping; Yan, Chuangye; Shi, Yigong (2014-02-06). “Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA”. Nature 506 (7486): 116–120. doi:10.1038/nature12803. ISSN 1476-4687. PMID 24240276.
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- ^ Golas, Monika M.; Bjoern Sander; Cindy L. Will; Reinhard Lührmann; Holger Stark (2005-03-18). “Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy”. Molecular Cell 17 (6): 869–883. doi:10.1016/j.molcel.2005.02.016. ISSN 1097-2765. PMID 15780942 2012年1月25日閲覧。.
- ^ Sander, Bjoern; Monika M. Golas; Evgeny M. Makarov; Hero Brahms; Berthold Kastner; Reinhard Lührmann; Holger Stark (2006-10-20). “Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy”. Molecular Cell 24 (2): 267–278. doi:10.1016/j.molcel.2006.08.021. ISSN 1097-2765. PMID 17052460 2012年1月26日閲覧。.
- ^ Will, Cindy L.; Reinhard Lührmann (2011-07-01). “Spliceosome Structure and Function”. Cold Spring Harbor Perspectives in Biology 3 (7): a003707. doi:10.1101/cshperspect.a003707. PMC 3119917. PMID 21441581 2012年1月25日閲覧。.
[続きの解説]
「核内低分子リボ核タンパク質」の続きの解説一覧
- 1 核内低分子リボ核タンパク質とは
- 2 核内低分子リボ核タンパク質の概要
- 3 抗snRNP抗体
- 核内低分子リボ核タンパク質のページへのリンク
